A case is reported of a patient with autopsy-confirmed idiopathic Parkinson's disease in addition to chronic paranoid schizophrenia. Difficulties in the diagnosis and management of these two conditions are described. Because of the treatment implications, clinicians should be aware that idiopathic Parkinson's disease and schizophrenia can coexist.
References
1.
FriedmanJH, MaxJ, SwiftRIdiopathic Parkinson's disease in a chronic schizophrenic patient: long-term treatment with clozapine and L-DOPA.Clin Neuropharmacol1987; 10: 470–475.
2.
RajputAH, RozdilskyB, HornykiewiczO.Reversible drug-induced parkinsonism. Clinicopathologic study of two cases.Arch Neurol1982; 39: 644–649.
3.
GoetzCGDrug-induced parkinsonism and idiopathic Parkinson's disease.Arch Neurol1983; 40: 325–326.
4.
FriedmanJHThe management of levodopa psychosis.Clin Neuropharmacol1991; 14: 283–295.
5.
FriedmanJH, LannonMCClozapine in the treatment of psychosis in Parkinson's disease.Neurology1989; 39: 1219–1221.
6.
ScholzE, DichgansJTreatment of drug-induced exogenous psychosis in parkinsonism with clozapine and fluperlapine.Eur Arch Psychiatry Neurol Sci1985; 235: 60–64.
7.
WoltersEC, HurwitzTA, MakE.Clozapine in the treatment of parkinsonian patients with dopaminergic psychosis.Neurology1990; 40: 832–834.
8.
LiebermanJA, JohnsCA, KaneJ.M.Clozapine-induced agranulocytosis: non-cross-reactivity with other psychotropic drugs.J Clin Psychiatry1988; 49: 271–277.
