This paper reviews recent literature on schizoaffective disorder. Research studies of diagnosis, clinical course and outcome and family history are evaluated. It is concluded that schizoaffective disorder is a heterogeneous category which includes patients with bipolar disorder, schizophrenia, a genetically distinct psychosis and a genetic disposition to both schizophrenia and bipolar disorder.
References
1.
KraepelinE.Dementia praecox and paraphrenia. BarclayRM, trans. Edinburgh: E & S Livingstone, 1919.
2.
KraepelinE.Clinical psychiatry. DiefendorfAR, trans. The MacMillan Company: New York, 1921.
3.
BleulerE.A textbook of psychiatry. New York: The MacMillan Company, 1924.
KasaninJ.The acute schizo-affective psychoses. Am J Psychiatry1933; 13: 97–126.
6.
SchneiderK.Clinical psychopathology. New York: Grune and Stratton, 1959.
7.
PopeHG, LipinskiJ.Diagnosis in schizophrenia and manic-depressive illness: a reassessment of the specificity of “schizophrenic” symptoms in the light of current research. Arch Gen Psychiatry1978; 35: 811–828.
8.
SpitzerRL, EndicottJ, RobinsE.Research diagnostic criteria (RDC) for a selected group of functional disorders, third edition. New York: Biometrics Research, New York State Psychiatric Institute, 1978.
9.
Diagnostic and statistical manual of mental disorders, third edition.Washington DC: American Psychiatric Press, Inc., 1980.
10.
Diagnostic and statistical manual of mental disorders, third edition, revised.Washington DC: American Psychiatric Press, Inc., 1987.
11.
BernerP, LenzG.Definitions of schizoaffective psychosis: mutual concordance and relationship to schizophrenia and affective disorder. In: MarnerasA, TsuangMT, eds. Schizoaffective psychosis.Berlin: Springer-Verlag, 1986: 31–49.
KendellRE. The relationship of schizoaffective illnesses to schizophrenic and affective disorders. In: MarnerasA, TsuangMT, eds. Schizoaffective psychosis.Berlin: Springer-Verlag, 1986: 18–30.
14.
TsuangMT, WoolsonRF, FlemingJA. Long-term outcome of major psychoses I. Schizophrenic and affective disorders compared with psychiatrically symptom-free surgical conditions. Arch Gen Psychiatry1979; 39: 1295–1301.
15.
CroughanJL, WelnerA, RobinsE.The group of schizoaffective and related psychoses — critique, record, follow-up, and family studies. Arch Gen Psychiatry1974; 31: 632–637.
16.
WelnerA, CroughanJ, FishmanR, The group of schizoaffective and related psychoses: a follow-up study. Compr Psychiatry1977; 18: 413–422.
17.
WelnerA, CroughanJL, RobinsE.The group of schizoaffective and related psychoses — critique, record, follow-up, and family studies. Arch Gen Psychiatry1974; 31: 628–631.
18.
WilliamsPV, McGlashanTH. Schizoaffective psychosis. Arch Gen Psychiatry1987; 44: 130–137.
19.
McGlashanTH, WilliamsPV. Schizoaffective psychosis. Arch Gen Psychiatry1987; 44: 138–139.
20.
HimmelhochJM, FuchsCZ, MaySJ, When a schizoaffective diagnosis has meaning. J Nerv Ment Dis1981; 163: 277–282.
21.
MajM, StaraceF, RemaliD.Prediction of outcome by historical, clinical and biological variables in schizoaffective disorder, depressed type. J Psychiatr Res1987; 21: 289–295.
22.
ClaytonPC, RodinL, WinokurG.Family history studies: III. Schizoaffective disorder, clinical and genetic factors including a one to two year follow-up. Compr Psychiatry1968; 9: 31–49.
23.
TsuangMT, DempseyGM, RauscherF.A study of “atypical schizophrenia”: a comparison with schizophrenia and affective disorder by sex, age of admission, precipitant, outcome, and family history. Arch Gen Psychiatry1976; 33: 1157–1160.
24.
MollerHJ, Schmid-BodeN, Cording-TommelC, Psycho-pathological and social outcome in schizophrenia versus affective/schizoaffective psychoses and prediction of poor outcome in schizophrenia. Acta Psychiatr Scand1988: 379–389.
25.
FeighnerJP, RobinsE, GuzeSB, Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry1972;. 26: 57–63.
26.
AngstJ, FelderW, LohmeyerB.Course of schizoaffective psychoses: results of a followup study. Schizophr Bull1980; 6: 579–584.
27.
GrossmanLS, HarrowM, FudalaJL, The longitudinal course of schizoaffective disorders: a prospective follow-up study. J Nerv Ment Dis1984; 172: 140–149.
28.
TsuangMT, DempseyGM. Long-term outcome of major psychosis II. Schizoaffective disorder compared with schizophrenia, affective disorders, and a surgical control group. Arch Gen Psychiatry1979; 36: 1302–1304.
29.
HarrowM, GrossmanLS. Outcome in schizoaffective disorders: a critical review and reevaluation of the literature. Schizophr Bull1984; 10: 87–108.
30.
McGlashanTH, WilliamsPV. Predicting outcome in schizoaffective psychosis. J Nerv Ment Dis1990; 178: 518–520.
31.
del Rio VegaJM, Ay uso-GutierrezJL. Course of schizoaffective psychosis: a retrospective study. Acta Psychiatr Scand1990; 81: 534–537.
32.
BrockingtonIF, KendellRE, WainwrightS.Depressed patients with schizophrenic or paranoid symptoms. Psychol Med1980; 10: 665–675.
33.
CoryellW, LavoriP, EndicottJ, Outcome in schizoaffective, psychotic, and nonpsychotic depression. Arch Gen Psychiatry1984; 41: 787–791.
34.
OpjordsmoenS.Long-term course and outcome in unipolar affective and schizoaffective psychoses. Acta Psychiatr Scand1989; 79: 317–326.
35.
CoryellW, GroveN, Van EerdeweghM, Outcome in RDC schizo-affective depression: the importance of diagnostic sub-typing. J Affective Disord1987; 12: 47–56.
36.
CoryellW, KellerM, LavoriP, Affective syndromes, psychotic features, and prognosis I. Depression. Arch Gen Psychiatry1990; 47: 651–657.
37.
AbramsR, TaylorMA. Mania and schizo-affective disorder, manic type: a comparison. Am J Psychiatry1976; 133: 1445–1447.
38.
AbramsR, TaylorMA. Importance of schizophrenic symptoms in the diagnosis of mania. Am J Psychiatry1981; 138: 65 8–661.
39.
RosenthalNE, RosenthalLN, StalloneF, Toward the validation of RDC schizoaffective disorder. Arch Gen Psychiatry1980; 37: 804–810.
40.
BrockingtonIF, WainwrightS, RendallR.Manic patients with schizophrenic or paranoid symptoms. Psychol Med1980; 10: 73–83.
41.
PopeHG, LipinskiJF, CohenBM, Schizoaffective disorder: an invalid diagnosis? A comparison of schizoaffective disorder, schizophrenia, and affective disorder. Am J Psychiatry1980; 137: 921–927.
42.
MajM.Clinical course and outcome of schizoaffective disorders. Acta Psychiatr Scand1985; 72: 542–550.
43.
ClaytonPC. Schizoaffective disorders. J Nerv Ment Dis1982; 170: 646–650.
44.
LevinsonDF, LevittMEM. Schizoaffective mania reconsidered. Am J Psychiatry1987; 144: 415–425.
45.
CoryellW, RelierM, LavoriP, . Affective syndromes, psychotic features, and prognosis II. Mania. Arch Gen Psychiatry1990; 47: 658–662.
46.
Zerbin-RudinE.Schizoaffective and other atypical psychoses: the genetical aspect. In: MarnerosA, TsuangMT, eds. Schizoaffective psychoses.Berlin: Springer-Verlag: 1986: 225–231.
47.
WelnerA, WelnerZ, FishmanR.The group of schizoaffective and related psychoses: IV. A family study. Compr Psychiatry1979; 20: 21–26.
48.
MendlewiczJ, LinkowskiP, WilmotteJ.Relationship between schizoaffective illness and affective disorders to schizophrenia: morbidity risk and genetic transmission In: ObiolsJ, BallusC, MonclusEG, , eds. Developments in psychiatry, volume 2A: biological psychiatry today. Proceedings of the IInd World Congress of Biological Psychiatry, August 31st to September 6th, 1978, Barcelona, Spain. Amsterdam: Elsevier/North-Holland Biomedical Press, 1979: 406–411.
49.
TsuangMT, DempseyGM, DvoredskyA, A family history study of schizo-affective disorder. Biol Psychiatry1977; 12: 331–338.
50.
BaronM.Linkage between an X-chromosome marker (Deutan colour blindness) and bipolar affective disorder: occurrence in the family of a lithium carbonate-responsive schizoaffective proband. Arch Gen Psychiatry1977; 34: 721–725.
51.
KaijL.Atypical endogenous psychosis. Report on a family. Br J Psychiatry1967; 113: 415–422.
52.
WålinderJ.Recurrent familial psychosis of the schizoaffective type. Acta Psychiatr Scand1972; 33: 377–399.
53.
MajM.A family study of two subgroups of schizoaffective patients. Br J Psychiatry1989; 154: 640–643.
54.
PerrisC, BrockingtonIF. Cycloid psychoses and their relation to the major psychoses. In: PerrisC, StruweG, JanssonB, eds. Biological psychiatry 1981. Amsterdam: Elsevier, 1981: 447–450.
55.
VoglG, ZaudigM.Investigation of operationalized diagnostic criteria in the diagnosis of schizoaffective and cycloid psychoses. Compr Psychiatry1985; 26: 1–10.
56.
MajM.Clinical course and outcome of cycloid psychotic disorder: a three-year prospective study. Acta Psychiatr Scand1988; 78: 182–187.
57.
KendlerRS, TsuangMT. Identical twins concordant for the progression of affective illness to schizophrenia. Br J Psychiatry1982; 141: 563–566.
DalbyJT, MorganD, LeeML. Single case study: schizophrenia and mania in identical twin brothers. J Nerv Ment Dis1986; 174: 304–308.
60.
CohenSM, AllenMG, PollinW, Relationship of schizo-affective psychosis to manic depressive psychosis and schizophrenia: findings in 15,909 veteran pairs. Arch Gen Psychiatry1972; 26: 539–546.
61.
RiceJ, ReichT, AndreasenNC, Familial transmission of bipolar illness. Arch Gen Psychiatry1987; 44: 441–447.
62.
BaronM, GruenR, AsnisL, Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission. Acta Psychiatr Scand1982; 65: 253–262.
63.
KendlerKS, GruenbergAM, TsuangMT. A DSM-III family study of the nonschizophrenic psychotic disorders. Am J Psychiatry1986; 143: 1098–1105.
64.
MendlewiczJ.X-linkage of bipolar illness and the question of schizoaffective illness. In: BelmakerRH, van PraagHM, eds. Mania: an evolving concept.New York: Spectrum Publications, 1979: 89–96.
65.
ScharfetterCS, NusperliM.The group of schizophrenias, schizoaffective psychoses, and affective disorders. Schizophr Bull1980; 6: 586–591.
66.
CoryellW, ZimmermanM.The heritability of schizophrenia and schizoaffective disorder: a family study. Arch Gen Psychiatry1988; 45: 323–327.
67.
AngstF, FelderW, LohmeyerB.Schizoaffective disorders. Results of a genetic investigation I. J Affective Disord1979; 1: 139–153.
68.
TsuangMT. Schizoaffective disorder: dead or alive?Arch Gen Psychiatry1979; 36: 633–634.
69.
ProcciWR. Schizo-affective psychosis: fact or fiction? A survey of the literature. Arch Gen Psychiatry1976; 33: 1167–1178.
GershonES, HamovitJ, GuroffJJ, A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Arch Gen Psychiatry1982; 39: 1157–1167.
72.
CrowTJ. Nature of the genetic contribution to psychotic illness: a continuum viewpoint. Acta Psychiatr Scand1990; 81: 401–408.
73.
GershonES, DelisiLE, HamovitJ, A controlled family study of chronic psychoses: schizophrenia and schizoaffective disorder. Arch Gen Psychiatry1988; 45: 328–336.
74.
AbramsR.Genetic studies of the schizoaffective syndrome: a selective review. Schizophr Bull1984; 10: 26–29.
75.
DeLisiL, GoldinLR, MaxwellE, Clinical features of illness in siblings with schizophrenia or schizoaffective disorder. Arch Gen Psychiatry1987; 44: 891–896.
