Five patients meeting the DSM-III-R criteria for social phobia, without any other psychiatric diagnosis, were treated with clonazepam, a high potency benzodiazepine. All patients improved markedly within four weeks. By the end of the eighth week of treatment, a marked improvement of their symptoms was reported. The adverse effects were minimal at an average dose of 3 mg per day. The authors suggest that clonazepam is a safe and effective medication in the treatment of social phobia. Moreover, clonazepam is easier to use as compared to other drugs which are used (atenolol, phenelzine, alprazolam).
References
1.
Diagnostic and statistical manual of mental disorders, third edition.Washington, DC: American Psychiatric Press, Inc.1980; 227–228.
2.
ReichJ.The epidemiology of anxiety.J Nerv Ment Dis1986; 174(3): 129–136.
3.
MarksI.M.Fears and phobias.New York: Academic Press,1969.
LiebowitzM.R., GormanJ.M., FyerA.J.Social phobia: review of a neglected anxiety disorder.Arch Gen Psychiatry1985; 42: 729–736.
6.
GormanJ.M., GormanL.K.Drug treatment of social phobia.J Affective Disord1987; 13: 183–192.
7.
FallonI.R.H., LloydG.G., HarpinR.F.The treatment of social phobia: real-life rehearsal with nonprofessional therapists.J Nerv Ment Dis1981; 169(3): 180–184.
8.
LiebowitzM.R., GormanJ.M., FyerA.J.Pharmaco-therapy of social phobia: an interim report to placebo-controlled comparison of phenelzine and atenolol.J Clin Psychiatry1988; 49: 252–257.
9.
ReichJ., YatesW.A pilot study of treatment of social phobia with alprazolam.Am J Psychiatry1988; 145: 590–594.
PinderR., BrogdenR., SpeightT.Clonazepam: a review of its pharmacological properties and therapeutic efficacy in epilepsy.Drugs1976; 12: 321–361.
12.
FontaineR., ChouinardG.Antipanic effect of clonazepam (letter to editor).Am J Psychiatry1984; 141: 149.
13.
BeaudryP., FontaineR., ChouinardG.Clonazepam in the treatment of patients with recurrent panic attacks.J Clin Psychiatry1986; 47: 83–85.
14.
PollackM.H., TesarG.E., RosenbaumJ.F.Clonazepam in the treatment of panic disorder and agoraphobia. A one-year follow-up.J Clin Psychopharmacol1986; 6: 302–304.
15.
PollackM.H.Clonazepam: a review of open clinical trials.J Clin Psychiatry (suppl)1987; 48(10): 12–14.
16.
ChouinardG.Clonazepam in acute and maintenance treatment of bipolar affective disorder.J Clin Psychiatry (suppl)1987; 48(10): 29–36.
17.
WaltersA.S., HeningW.Clinical presentation and neuropharmacology of restless legs syndrome.Clin Neuropharmacol1987; 10(3): 225–237.
18.
Diagnostic and statistical manual of mental disorders, third edition, revised.Washington, DC: American Psychiatric Press, Inc.,1987: 241–243.
19.
RabkinJ.G., QuitkinF.M., McGrathP.Adverse reactions to monoamine-oxidase inhibitors. Part II. Treatment correlate and clinical management.J Clin Psychopharmacol1985; 5(1): 2–9.
20.
LaderM.Beta-adrenoceptor antagonists in neuropsychiatry: an update.J Clin Psychiatry1988; 49(6): 213–223.
21.
TesarG.F., RosenbaumJ.F., PollackM.H.Clonazepam versus alprazolam in the treatment of panic disorder: interim analysis of data from a prospective, double-blind, placebo-controlled trial.J Clin Psychiatry (suppl)1987; 48(10): 16–19.
22.
HermanJ.B., BrotmanA.W., RosenbaumJ.F.Rebound anxiety in panic disorder patients treated with shorter-acting benzodiazepines.J Clin Psychiatry (suppl)1987; 48(10): 22–26.
23.
AlbeckJ.H.Withdrawal and detoxification from benzodiazepine dependence: a potential role for clonazepam.J Clin Psychiatry (suppl)1987; 48(10): 43–48.
24.
CirauloD.A., BarnhillJ.G., GreenblattD.J.Abuse liability and clinical pharmacokinetics of alprazolam in alcoholic men.J Clin Psychiatry1988; 49(9): 333–337.