A 37 year old patient with chronic schizophrenia developed polydipsia and hyponatremia induced by several neuroleptics. We treated the patient successfully with molindone. The etiology of polydipsia with hyponatremia is discussed.
References
1.
JoseC.J., Perez-CruetJ.Incidence and morbidity of self-induced water intoxication in state mental hospital patients.Am J Psychiatry1979; 136: 221–222.
2.
UlowskyB.P., KirchD.G.Polydipsia and hyponatremia in psychiatric patients.Am J Psychiatry1988; 145; 675–683.
3.
SwansonA.G., IseriO.A.Acute encephalopathy due to water intoxication.N Engl J Med1958; 258: 831–834.
4.
SandiferM.G.Hyponatremia due to psychotropic drugs.J Clin Psychiatry1983; 44: 301–303.
5.
ShenW.W., SataL.S.Hypothalamic dopamine receptor supersensitivity? A pilot study of self-induced water intoxication.Psychiatr J Univ Ottawa1983; 8: 154–158.
6.
HobsonJ.A., EnglishJ.T.Self-induced water intoxication.Ann Intern Med1963; 58: 324–332.
7.
KostenT.R., CampW.Inappropriate secretion of antidiuretic hormone in a patient receiving piperazine phenothiazines.Psychosomatics1980; 21: 351–355.
8.
ClaghornJ.L.Review of clinical and laboratory experiences with molindone hydrochloride.J Clin Psychiatry1985; 46(8 Sec 2): 30–33.
9.
GallantD.M., BishopM.P., SteeleC.A.Molindone: a crossover evaluation of capsule and tablet formulations in severely ill schizophrenic patients.Curr Ther Res1973; 15: 915–918.
