Cholecystokinin-tetrapeptide (CCK-4) and placebo were injected to 11 panic disorder patients. CCK-4 induced a panic attack identical to spontaneous panic attacks in all patients; placebo did not induce any attacks. The role of CCK-4 in anxiety disorders is discussed.
References
1.
BeinfeldM.C.Cholecystokinin in the central nervous system: a mini-review.Neuropeptides1983; 3: 411–427.
2.
RehfeldJ.F.Neuronal cholecystokinin: one or multiple transmitter.J Neurochem1985; 44: 1–10.
3.
GoltermannN.R., RehfeldJ.F., Roigaard-PetersonH.In vivo biosynthesis of cholecystokinin in rat cerebral cortex.J Biol Chem1980; 225: 6181–6185.
4.
SaitoA., SankaranH., GoldfineI.D.Cholecystokinin receptors in the brain: characterization and distribution.Science1980; 208: 1155–1156.
ChiodoA., BunneyB.S.Proglumide: selective antagonism of the excitatory effects of cholecystokinin in central nervous system.Science1983; 196: 998–1000.
7.
BradwejnJ., de MontignyC.Benzodiazepines antagonize cholecystokinin-induced activation of rat hippocampal neurons.Nature1984; 312: 363–364.
8.
BradwejnJ., de MontignyC.Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-induced activation of hippocampal pyramidal neurons: a microiontrophoretic study in the rat.Eur J Pharmacol1985; 112: 415–418.
9.
de MontignyC.Cholecystokinin tetrapeptide induces panic attacks in healthy volunteers. Presented at the 11th Annual Scientific Meeting of the Canadian College of Neuropsychopharmacology, Montreal, May 4th 1988.
10.
HommerD.W., PickarD., CrawleyJ.N.The effects of cholecystokinin-like peptides in schizophrenics and normal human subjects.Ann N Y Acad Sci1985; 448: 542–552.
