The emergence of depression, parkinsonism, and akathisia after neuroleptic therapy was associated with increased length of hospital-stay in schizophrenics with affective heredity only. In schizophrenics with schizophrenic heredity, increased length of hospital-stay was associated with residual hallucinations and apathy. In the former patients, findings were theoretically attributed to a putative biogenetic abnormality sensitive to the effects of neuroleptic drugs.
References
1.
GaldiJ., ReiderR.O., SilberD.Genetic factors in the response to neuroleptics in schizophrenia: a psychopharmacogenetic study.Psychol Med1981; 11: 713–728.
2.
GaldiJ., KellyJ.T., ReiderR.O.The role of genetic factors in the induction of extrapyramidal side-effects in schizophrenia. Presented at the VIIth World Congress of Psychiatry, Vienna, 1983.
3.
BowersM.B.Family history and CSF homovanillic acid pattern during neuroleptic treatment.Am J Psychiatry1984; 141: 296–298.
4.
Van PuttenT., MarderS.R.The dysphoric syndrome and its relation to EPS. Presented at the VIIth World Congress of Psychiatry, Vienna, 1983.
5.
HogartyG.E., SchoolerN.R., UlrichR.Fluphenazine and social therapy in the aftercare of schizophrenic patients.Arch Gen Psychiatry1979; 36: 1283–1294.
6.
GaldiJ.The causality of depression in schizophrenia.Br J Psychiatry1983; 142: 621–625.
7.
CarpenterW.T., McGlashanT.H., StraussJ.S.The treatment of acute schizophrenia without drugs: an investigation of some current assumptions.Am J Psychiatry1977; 134: 14–20.
8.
SternM.J., PillsburyJ.A., SonnenbergS.M.Postpsychotic depression in schizophrenics.Compr Psychiatry1972; 13: 519–528.
9.
SinghM.M.Dysphoric response to neuroleptic treatment in schizophrenia and its prognostic significance.Arch Gen Psychiatry1976; 37: 191–204.
10.
SinghM.M., KayS.R.Dysphoric response to neuroleptic treatment in schizophrenia: its relationship to autonomic arousal and prognosis.Biol Psychiatry1979; 14: 277–294.
11.
LorrM., KlettC.J., McNairD.M.Syndromes of psychosis.London: Pergammon,1963.
12.
ElBurdock, HakeremG., HardestyA.S.A ward behavior scale for use with mental hospital patients.J Clin Psychol1960; 16: 246–247.
13.
KatzM.M., LyerlyS.B.Methods for measuring adjustment and social behavior in the community. I: Rationale, description, discriminative validity, and scale development.Psychol Rep Monograph1963; 13: 503–535.
14.
HartmannW., KindJ., MeyerJ.E.Neuroleptic drugs and the prevention of relapse in schizophrenia: a workshop report.Schizophr Bull1980; 6: 536–543.
15.
McGlashanT.H., CarpenterW.T.Postpsychotic depression in schizophrenia.Arch Gen Psychiatry1976; 33: 14–19.
16.
WegnerJ.T., CatalanoF., GilbralterJ.Schizophrenics with tardive dyskinesia.Arch Gen Psychiatry1985; 42: 860–865.
