Recent advances in the clinical neurosciences have begun to expand and change our understanding of how the brain functions. As further neuroscientific principles are delineated we may gain insights into the underlying pathophysiology of some psychiatric disorders and through this new understanding we may be able to define new therapeutic interventions. Two illustrative examples of neuroscientific research are discussed and reviewed both in terms of the promises and dangers inherent in these new approaches to the mind.
References
1.
JohnstoneEC, CrowTJ, FrithCDCerebral ventricular size and cognitive impairment in chronic schizophrenia.Lancet1976; 7992: 924–926.
2.
WeinbergerDR, TorreyEF, NeophytidesA, WyattRJLateral cerebral ventricular enlargement in chronic schizophrenia.Arch Gen Psychiatry1979; 36: 735–739.
3.
NasrallahHA, JacobyCG, McCalley-WhittersCerebral ventricular enlargement in subtypes of chronic schizophrenia.Arch Gen Psychiatry1982; 39: 774–777.
4.
PearlsonGD, GarbaczDJ, BreakeyWRLateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder.Psychiatr Res1984; 12: 1–9.
5.
MorihisaJM, DuffyFH, WyattRJBrain electrical activity mapping (BEAM) in schizophrenic patients.Arch Gen Psychiatry1983; 40: 719–728.
6.
KarsonCN, CoppolaR, MorihisaJMComputed electroencephalographic activity mapping in schizophrenia.Arch Gen Psychiatry1987; 44: 514–517.
7.
MorihisaJM, Me AnultyGBStructure and function: brain electrical activity mapping and computed tomography in schizophrenia.Biol Psychiatry1985; 20: 3–19.
8.
WeinbergerDR, BermanKF, ZeeRFPhysiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. I: Regional cerebral blood flow (rCBF) evidence.Arch Gen Psychiatry1986; 43: 114–125.
9.
BermanKF, ZeeRF, WeinbergerDRPhysiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. II: Role of medication, attention and mental effort.Arch Gen Psychiatry1986; 43: 126–143.
10.
WolkinA, JaegerJ, BrodieJDPersistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by Positron Emission Tomography.Am J Psychiatry1985; 142: 564–571.
11.
MorihisaJMFunctional brain imaging in psychiatry. In: HalesR, FrancesA eds. APA Annual Review, Volume VI. Washington, D.C.: American Psychiatric Press, 1987: 300–325.
12.
AndreasenN, NasrallahHA, DunnVStructural abnormalities in the frontal system in schizophrenia.Arch Gen Psychiatry1986; 43: 136–144.
13.
MilnerBEffects of different brain lesions on card sorting.Arch Neurol1963; 9: 100–110.
14.
Goldman-RakicPS, IsseroffA, SchwartzMLThe neurobiology of cognitive development. In: MussenP ed. The handbook of child psychology: biology of infancy development.New York: Wiley,1983.
15.
UngerstedtUSix-hydroxydopamine-induced degeneration of the nigrostriatal dopamine pathway: the turning syndrome.Pharmacol Ther Behav1976; 2: 37–40.
16.
GlickSD, MorihisaJMChanges in sensitivity in morphine-induced circling behavior after chronic treatment and persistence after withdrawal in rats.Nature1976; 260: 159–161.
17.
MorihisaJM, GlickSDMorphine-induced rotation in rats and mice: species differences, persistence of withdrawal-induced rotation and antagonism by naloxone.Brain Res1977; 123: 180–187.
18.
PerlowMJ, FreedWF, HofferBJ, SeigerA, OlsonL, WyattRJBrain grafts reduce motor abnormalities produced by destruction of the nigrostriatal dopamine system.Science1979; 204: 643–647.
19.
FreedWJ, MorihisaJM, SpoorHETransplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behavior.Nature1981; 292: 351–352.
20.
FreedWJFunctional brain tissue transplantation: reversal of lesion-induced rotation by intraventricular substantia nigra and adrenal medulla grafts, with a note on intracranial retinal grafts.Biol Psychiatry1983; 18: 1205–1267.
21.
MorihisaJM, NakamuraRK, FreedWJAdrenal medulla grafts survive and exhibit catecholamine-specific fluorescence in the primate brain.Exper Neurol1984; 84: 643–653.
22.
OlsonLFluorescence histochemical evidence for axonal growth and secretion from transplanted adrenal medullary tissues.Histochemie1970; 22: 1–7.
23.
OlsonL, SeigerA, FreedmanRChromaffin cells can innervate brain tissue: evidence from intraocular double grafts.Exper Neurol1980; 70: 414–426.
24.
TischelerAS, GreeneLAPhenotypic plasticity of pheochromocytoma and normal adrenal medullary cells. In: ErankoO, SoinilaS, PaivarintaH eds. Histochemistry and cell biology of autonomic neurons, SIF cells and paraneurons. Advances in biochemical pharmacology, Vol. 4. New York: Raven Press, 1980: 61–88
25.
WyattRJ, MorihisaJM, NakamuraRKTransplanting tissue into the brain for function: use in a model for Parkinson's Disease. In: MartinJB, BarchasJD eds. Neuropeptides in neurologic and psychiatric disease.New York: Raven Press, 1986: 199–208.
26.
BacklundEO, GranbergB, HambergerETransplantation of adrenal medullary tissue to striatum in Parkinsonism.J Neurosurg1985; 62: 169–173.
27.
MorihisaJM, NakamuraRK, FreedWJTransplantation techniques and the survival of adrenal medulla autografts in the primate brain. In: AzmitiaEC, BjorklundA eds. Cell and tissue transplantation into the adult brain.New York: Annals N.Y. Acad Sci1987; 495: 599–605.
28.
RosseRB, OwenCM, MorihisaJMBrain imaging and laboratory testing in neuropsychiatry. In: HalesRE, YudofskySC eds. Textbook of neuropsychiatry.Washington, D.C.: American Psychiatric Press, 1987: 17–39.