Tetrabenazine has been used for treatment of tardive dyskinesia sporadically over the past twenty years. Dose has usually been decided empirically without assaying blood levels. This report describes 23 cases treated successfully with tetrabenazine. Our method of measuring levels of tetrabenazine and its metabolites in biological samples is described briefly.
References
1.
Kulenkampff VonC, TarnowGEin eigentumliches Syndrom im oralen Bereich bei Megaphenapplikation.Nervenarzt1956; 27(4): 178–180.
2.
UhrbrandL, FaurbyeAReversible and irreversible dyskinesia after treatment with perphenazine, chlorpromazine, reserpine and electroconvulsive therapy.Psychopharmacologia1960; 1: 408–418.
3.
HunterR, EarlCJ, ThornicroftSAn apparently irreversible syndrome of abnormal movements following phenothiazine medication.Proc Royal Soc Med1964; 57: 758–762.
4.
CreeseI, LeffSEDopamine receptors: a classification.J Clin Psychopharmacol1982; 2(5): 329–335.
5.
JesteDV, WyattRJIn search of treatment for tardive dyskinesia: review of the literature.Schizophr Bull1979; 5(2): 251–293.
6.
JesteDV, WyattRJTherapeutic strategies against tardive dyskinesia.Arch Gen Psychiatry1982; 39: 803–816.
7.
LingjaerdeOTetrabenazine in the treatment of psychoses.Acta Psychiatr Scand1963; Suppl 170: 1–109.
8.
SwashM, RobertsAH, ZakkoH, HeathfieldK.W.G.Treatment of involuntary movement disorders with tetrabenazine.J Neurol Neurosurg Psychiatry1972; 35: 186–191.
9.
RobertsMS, WatsonHM, McLeanS, MillingenKSDetermination of therapeutic plasma concentrations of tetrabenazine and an active metabolite by high-performance liquid chromatography.J Chromatogr1981; 226: 175–182.
10.
MehvarR, JamaliF, WatsonM.W.B., SkeltonDSDirect injection HPLC of tetrabenazine and its metabolites in plasma of humans and rats.J Pharma Sci1986; 75: 1006–1009.
