Magnetic resonance imaging (MRI) is a relatively new radiological technique that may be useful in the study of psychiatric illness. MRI gives detailed structural information about the brain and also allows quantification of functional change. Current areas of study relevant to psychiatry include: schizophrenia, dementia, epilepsy and, to a lesser extent, alcohol and affective disorders. The authors review the basic principles of MRI, discuss the recent application to psychiatry, indicate its potential advantages and comment on the current limitations of this imaging modality.
OldendorfW.H.The use and promise of nuclear magnetic resonance imaging in epilepsy.Epilepsia1984; 25(Suppl 2): S105–S117.
10.
SteinerR.E., BydderG.M.Clinical nuclear magnetic resonance imaging. In: DawsonA.M., CompstonN.D., BesserG.M., eds. Recent advances in medicine, No. 19.London: Churchill-Livingstone, 1984: 39–56.
11.
BilanuikL.T., ZimmermanR.A.Wehrli FW, et al. Cerebral magnetic resonance: comparing high and low field strength imaging.Radiology1984; 153: 409–414.
12.
ConlonP., TrimbleM.R., RogersD., CallicottC.Magnetic resonance imaging in epilepsy: a controlled study.Epilepsy Res (in press).
13.
YoungI.R., HallA.S., PallisC.A., BydderG.M., LeggN.J., SteinerR.E.Nuclear magnetic resonance imaging of the brain in multiple sclerosis.Lancet1981; ii: 1063–1065.
14.
SaundersR.D., SmithH.Safety aspects of NMR in clinical imaging.Br Med Bull1984; 40: 148–154.
15.
Anonymous.Safety of NMR.(Editorial) Lancet1985; 4: 913–914.
16.
BailesD.R., YoungI.R., ThomasD.J.NMR imaging of the brain using spin-echo sequences.Clin Radiol1982; 33: 395–414.
17.
HeroldS., FrackowiakR.J.New methods in brain imaging.Psychol Med1986; 16: 241–245.
18.
TrimbleM.R.New brain imaging techniques and psychiatry. In: Granville-GrossmanK., ed. Recent advances in clinical psychiatry.Edinburgh: Churchill Livingstone, 1985: 225–244.
19.
JacobyR.J.Computed tomography in dementia and depression. In: Granville-GrossmanK., ed. Recent advances in clinical psychiatry.Edinburgh: Churchill Livingstone, 1984(4): 123–139.
20.
EarnestM.P., HeatonR.K., WilkinsonW.E., MankeW.F.Cortical atrophy, ventricular enlargement and intellectual impairment in the aged.Neurology1979; 29: 1138–1143.
21.
HachinskiV.C., IliffL.D., ZilkaE.Cerebral blood flow in dementia.Arch Neurol1975; 32: 632–637.
22.
AnguarD.H., GustafsonL.Regional blood flow in organic dementia with early onset.Acta Neurol Scand (Suppl 46)1970; 43: 72–73.
23.
FrackowiakR.S.J., PoszilliC., LeggN.J.Regional cerebral oxygen supply and utilization in dementia — a clinical and physiological study with Oxygen-15 and position tomography.Brain1981; 104: 753–778.
24.
BryanR.N., WillcottM.R., SchneidersN.J., FordJ.J., DermanH.S.Nuclear magnetic resonance evaluation of stroke.Radiology1983; 149: 189–192.
25.
ErkinjunttiT., SipponenJ.T., IivanainenM., KetonenL., SulkavaR., SepponenR.E.Cerebral NMR and CT imaging in dementia.J Comput Assist Tomogr1984; 8 (4): 614–618.
26.
ErkinjunttiT., KetonenL., SulkavaR., SipponenJ., VuorialhoM., IivanainenM.Do white matter changes on MRI and CT differentiate vascular dementia from Alzheimer's disease?J Neurol Neurosurg Psychiatry1987; 50: 37–42.
27.
Brant-ZawadzkiM., FeinG., Van DykeC., KiernanR., DavenportL., de GrootJ.MR images of the aging brain: patchy white matter lesions and dementia.AJNR1985; 6 (5): 675–682.
28.
KinkelW.R., JacobsL., PolachiniI., BatesV., HeffnerR.R.Subcortical arteriosclerotic encephalography (Binswanger's Disease). Computed tomographic, nuclear magnetic resonance and clinical correlations.Arch Neurol1985; 42: 951–959.
BessonJ.A., MutchW.J., SmithF.W., CorriganF.M.The relationship between Parkinson's disease and dementia: a study using proton NMR imaging parametersBr J Psychiatry1985; 147: 380–382.
34.
AndreasenN.C.Negative symptoms in schizophrenia: definition and reliability.Arch Gen Psychiatry1982; 39: 784–788.
35.
JohnstoneE.C., CrowT.J., FrithC.D., HusbandJ., KreelL.Cerebral ventricular size and cognitive impairment in schizophrenia.Lancet1976; ii: 924–926.
36.
AndreasenN.C., OlsenS., DennertJ.W., SmithM.R.Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms.AM J Psychiatry1982a; 139: 292–302.
37.
LuchinsD.J.Computed tomography in schizophrenia.Arch Gen Psychiatry1982; 39: 859–860.
38.
DonnellyE.F., WeinbergerD.R., WaldmanI.N., WyattR.J.Cognitive impairment associated with morphological brain abnormalities on computer tomography in chronic schizophrenic patients.J Nerv Ment Dis1980; 168: 305–308.
39.
WeinbergerD.R., BigelowL.D., KliemanJ.Cerebral ventricular enlargement in chronic schizophrenia: an association with poor response to treatment.Arch Gen Psychiatry1980; 37: 11–13.
40.
IngvarD.H., FranzenG.Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia.Acta Psychiatr Scand1974; 50: 425–462.
41.
ArielR.N., GoldenC.J., BergR.A.Regional blood flow in schizophrenics: tests using the xenon Xe-133 inhalation method.Arch Gen Psychiatry1983; 40: 258–263.
42.
BuchsbaumM.S., IngvarD.H., KesslerR., WatersR.N.Cerebral glucography with positron tomography: use in normal subjects and in patients with schizophrenia.Arch Gen Psychiatry1982; 39: 251–259.
43.
FarkasT., WolfA.P., JaegerJ., BrodieJ.D., ChristmanD.R., FowlerJ.S.Regional brain glucose metabolism in chronic schizophrenia.Arch Gen Psychiatry1984; 41: 293–300.
44.
DeLisiL.E., HolocombH.H., CohenR.M., PickarD., CarpenterW., MorihisaJ.M., KingC., KesslerR., BuchsbaumM.S.Positron emission tomography in schizophrenic patients with and without neuroleptic medication.J Cereb Blood Flow Metab1985; 5: 201–206.
45.
WeinbergerD.R., BermanK.F., ZecR.F.Physiological dysfunction of dorso-lateral prefrontal cortex in schizophrenia. 1. Regional cerebral blood flow evidence.Arch Gen Psychiatry1986; 43: 114–124.
GurR.E., ResnickS.M., AlaviA., RubenC., CaroffS.Regional brain function in schizophrenia: I. A positron emission tomography study.Arch Gen Psychiatry1987; 44: 119–125.
48.
MorihisaJ.M., McAnultyG.E.Structure and function: brain electrical activity mapping and computed tomography in schizophrenia.Biol Psychiatry1985; 20: 3–19.
49.
AndreasenN., NasrallahH.A., DunnV.Structural abnormalities in the frontal system in schizophrenia.Arch Gen Psychiatry1986; 43: 136–144.
50.
JohnstoneE.C., CrowT.J., MacMillanJ.F., OwensD.G.C., BydderG.M., SteinerR.E.A magnetic resonance study of early schizophrenia.J Neurol Neurosurg Psychiatry1986; 49: 136–139.
51.
SmithR.C., CalderonM., RavichandranG.K.Nuclear magnetic resonance in schizophrenia: a preliminary study.Psychiatr Res1984; 12: 137–147.
LargenJ.W., SmithR.C., CalderonM.Abnormalities of brain structure and density in schizophrenia.Biol Psychiatry1984; 19: 991–1013.
54.
BessonJ.A.O., CorriganF.M., CherymanG.R., SmithF.W.Nuclear magnetic resonance brain imaging in chronic schizophrenia.Br J Psychiatry1987; 150: 161–163.
55.
CrowT.J.Molecular pathology of schizophrenia: more than one disease process?Br Med J1980; 280: 1–9.
56.
PandurangiA.K., DewanM.J., LeeS.H.The ventricular system in chronic schizophrenic patients: a computed tomography study.Br J Psychiatry1984; 144: 172–176.
57.
WeinbergerD.R., KleinmenJ.E., LuchinsD.J.Cerebellar pathology in schizophrenia: a controlled post-mortem study.Am J Psychiatry1980; 137: 359–361.
58.
MathewR.J., PartainL.Midsagittal sections of the cerebellar vermis and fourth ventricle obtained with magnetic resonance imaging of schizophrenic patients.Am J Psychiatry1985; 142 (8): 970.
NasrallahH.A., AndreasenN.C., CoffmanJ.A.A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia.Biol Psychiatry1986; 21: 274–282.
62.
WitelsonS.F.Bumps on the brain: right-left asymmetry as a key to functional lateralization. In: SegalowitzS.J., ed. Language function and brain organization.Orlando, FL: Academic Press, 1983: 117–144.
63.
MathewR.J., PartainC.L., PrakashR., KulkarniM.V., LoganT.P., WilsonH.A Study of the septum pellucidum and corpus callosum in schizophrenia with MR imaging.Acta Psychiatr Scand1985; 72: 414–421.
64.
WitelsonS.F.The brain connection: the corpus callosum is larger in left-handers.Science1985; 229: 665–668.
65.
SeemanM.V.Gender differences in schizophrenia.Can J Psychiatry1982; 27 (2): 107–112.
66.
Flor-HenryP.Gender hemispheric specialization and psychopathology.Soc Sci Med1978; 12B: 155–162.
67.
SutherlandS.The distribution of commissural fibres in the macaque monkey.J Neurol Psychiatry1940; 2: 9–18.
68.
McLachlanR.S., BlackS., NicholsonR.L., BlumeW.T.Nuclear magnetic resonance imaging: a new approach to the investigation of refractory temporal lobe epilepsy.Epilepsia1985; 26: 555–562.
69.
ConlonP., TrimbleM.R.Epileptic psychosis: a magnetic imaging study. Scientific Proceedings of 36th Annual Meeting, Canadian Psychiatric Association. Vancouver, BC, 1986; No. 18: 21.
70.
GallhoferB., TrimbleM.R., FrackowiakR., GibbsJ., JonesT.A study of cerebral blood flow and metabolism in epileptic psychosis using positron emission tomography and oxygen.J Neurol Neurosurg Psychiatry1985; 48: 201–206.
71.
DominoE.F., SharpR.R., LipperS., BallastC.L., DelidowB., BronzoM.R.NMR chemistry analysis of red blood cell constituents in normal subjects and lithium treated psychiatric patients.Biol Psychiatry1985; 20: 1277–1283.
72.
DominoE.F., MathewsB., TaitS.K., DemetriouS.K., FucekF.Red blood cell/plasma choline ratio — a possible biological marker of lithium therapy: clinical correlations and limitations. In: PepeuG., LadinskyH., eds. Advances in behavioural biology 25: cholinergic mechanisms.New York: Plenum Press, 1981: 891–900.
73.
Rangel-GuerraR.A., Perez PayanH., MinkoffL., ToddL.E.Nuclear magnetic resonance in bipolar affective disorders.AJNR1983; 4: 229–231.
74.
RosenthalJ., StraussA., MinkoffL., WinstonA.Identifying Lithium — responsive bipolar depressed patients using nuclear magnetic resonance.Am J Psychiatry1986; 143 (6): 779–780.
75.
HonerW.G., HurwitzT., LiD.K.B., PalmerM., PatyD.W.Temporal lobe involvement in multiple sclerosis patients with psychiatric disorders.Arch Neurol1987; 44: 187–190.
76.
BessonJ.A.O., GlenA.I.M., ForemanElNMR observations in alcoholic cerebral disorder and the role of vasopressin.Lancet1981; ii: 923–924.
77.
SmithM.A., ChickJ., KeanD.M.Brain water in chronic alcoholic patients measured by magnetic resonance imagery (letter).Lancet1985; i: 1273–1274.
78.
ManderA.J., SmithM.A., KeanD.M.Brain water measured in volunteers after alcohol and vasopressin (letter)Lancet1985; ii: 1075.
79.
BrownR.P., KneelandB.Visual imaging in psychiatry.Hosp Community Psychiatry1985; 36 (5): 489–496.
80.
RaddaG.K., BoreP.J., RajagopalanB.Clinical aspects of 31P NMR spectroscopy.Br Med Bull1984; 40: 155–159.
81.
HilalS.K., MaudsleyA.A., RaG.B.In vivo NMR imaging of sodium-23 in the human head.J Comp Assoc Tomgr1985; 9: 1–7.
