Authors describe a case of grand mal seizure associated with administration of desipramine and haloperidol.
Neuroleptic induced inhibition of desipramine metabolism is discussed as a possible explanation of unusually high desipramine plasma level of 610 ng/ml at the day of seizure.
References
1.
LuchinsD.J., OliverA.P., WyattR.J.Seizures with antidepressants: an in vitro technique to assess relative risk.Epilepsia1984; 25 (1): 25–32.
2.
PeckA.W., SternW.C., WatkinsonC.Incidence of seizures during treatment with tricyclic antidepressant drugs and buproprion.J Clin Psychiatry1983; 44: 197–201.
3.
Physician's desk reference, 40th Edition.Oradell, New Jersey: Medical Economics Comp. Inc., 1986; 1090.
4.
HanstedP.D.Drug interactions,5th Edition.Philadelphia, Pa.: Lea and Febiger, 1985: 347.
5.
GramL.F., OveroK.F.Drug interaction.Inhibitor-effect of neuroleptics on the metabolism of tricyclic antidepressants in man., Br Med J1972; 1: 463–466.
6.
GramL.F., OveroK.F., KirkL.Influence of neuroleptics and benzodiazepines on the metabolism of tricyclic antidepressants in man.Am J Psychiatry1974; 131: 863–867.
7.
VandelB., VandelS., AllersG.Interaction between amitriptyline and its metabolite nortriptyline and the correlation with clinical response.Psychopharmacology1979; 65: 187–190.
8.
BennettJ.A., HirschowitzJ., ZemlanF., Niven ThurmanD., GarverD.L.Combined thioridazine and desipramine: early antidepressant response.Psychopharmacology1984; 82 (3): 263–265.
BockJ.L., NelsonJ.C., GrayS., JatlowP.I.Desipramine hydroxylation: variability and effect of antipsychotic drugs.Clin Pharmacol Ther1983; 33 (3): 322–328.
11.
KilianM., FreyH.H.Central monoamines and convulsive thresholds in mice and rats.Neuropharmacology1973; 12: 681–692.
12.
ChenG., EnsorC.R., BohnerB.Studies of drug effects on electrically induced extensor seizures and clinical implication.Arch Int Pharmacodyn Ther1968; 172: 183–218.
13.
OliverA.P., LuchinsD.J., WyattR.J.Neuroleptic-induced seizures.Arch Gen Psychiatry1982; 39: 206–209.
14.
ItilT.M., SoldatosC.Epileptogenic side effects of psychotropic drugs.JAMA1980; 244: 1460–1463.
15.
MendezM.F., CummingsJ.L., BensonD.F.Epilepsy: psychiatric aspects and use of psychotropics.Psychosomatics1984; 25: 883–893.