A twenty-five-year old man presented with an acute paranoid disorder, and was subsequently diagnosed as having Klinefelter's Syndrome. Our review of previous reports suggests that the literature pointing out a particular association between Klinefelter's and schizophrenia may be misleading. In fact, Klinefelter's patients are liable to suffer from schizophrenia, paranoid disorders, or possibly other disorders.
References
1.
CaldwellP.D., SmithD.W.The XXY (Klinefelter's) Syndrome in childhood: detection and treatment.J Pediatr1972; 80: 250–258.
2.
PolaniP.E.Abnormal sex chromosomes and mental disorders.Nature1969; 223: 680–686.
3.
BakerD., TelferM.A.Chromosome errors in men with antisocial behavior.JAMA1970; 214: 869–878.
4.
PomeroyJ.C.Klinefelter's Syndrome and schizophrenia.Br J Psychiatry1980; 136: 597–599.
5.
RoyA.Schizophrenia and Klinefelter's Syndrome.Can J Psychiatry1981; 26: 262–264.
6.
American Psychiatric Association; diagnostic and statistical manual of mental disorders, Third Edition.Washington, D.C.: APA,1980: 196.
7.
MyhreS.A., RuvalcabaR.H.A., JonsonH.R., ThulineH., KelleyV.C.The effects of testosterone treatment in Klinefelter's Syndrome.J Pediatr1970; 76: 267–276.
8.
NeilsenJ.Cytogenetic investigations of patients with schizophrenia.J Acad Med Sci (Moscow)1975; 9: 64–68.