Abstract
Abstract
French
This paper discusses a case of neurotoxicity which developed in the course of treatment of bipolar affective disorder with Lithium. It deals with the issues of Lithium levels, concomitant usage of Phenothiazine and addresses the important question of toxicity occurring at normal serum Lithium levels.
References
1.
Shopsin
B.
,
Johnson
G.
,
Gershon
S.
Neurotoxicity with lithium: differential drug responsiveness. Int Pharmacopsychiatry 1971 ; 5 : 170 –182 .
2.
Strayhorn
J.M.
Jr
,
Nash
J.L.
Severe neurotoxicity despite “therapeutic” serum lithium levels. Dis Nerv Syst 1977 ; 38 (2 ): 107 –111 .
3.
Cohen
W.J.
,
Cohen
N.H.
Lithium carbonate haloperidol and irreversible brain damage. JAMA 1974 ; 230 (9 ): 1283 –1287 .
4.
Spiers
J.
,
Hirsch
S.R.
Severe lithium toxicity with “normal” serum concentrations. Med 1978 ; 6116 (1 ): 815 –816 .
5.
Dorus
E.
,
Pandey
G.N.
,
David
J.M.
Genetic determinant of lithium ion distribution. Arch Gen Psychiatry 1975 ; 32 (9 ): 1097 –1102 .
6.
Fraser
A.
,
Mendels
J.
,
Secunda
S.
,
Cochrane
C.M.
,
Bianchi
C.P.
The prediction of brain lithium concentration from plasma and erythrocyte measures , J Psychiatr Res 1973 ; 10 : 1 –7 .
7.
Elizure
A.
,
Shopsin
B.
,
Gershon
S.
,
Ehlenburg
A.
Intra extra cellular lithium ratios and clinical course in affective states. Clin Pharmacol Ther 1972 ; 13 : 947 –952 .
