Three cases are presented on patients on an MAOI who developed a transient syndrome of myoclonus, hyperreflexia, jaw quivering, teeth chattering and diaphoresis after L-Tryptophan was added. Caution is advised when considering the addition of a serotonergic agent to MAOTs.
CoppenA., ShawD.M., BristM.D.. Potentiation of the antidepressant effect of a monoamine oxidase inhibitor by tryptophan.Lancet1963; i: 79–81.
3.
KleinD.F., GittlemanR., QuitkinF.. Diagnosis and drug treatment of psychiatric disorders: adults and children.Baltimore: Williams and Wilkins, 1980.
4.
SternS.L., MendelsJ.Drug combinations in the treatment of refractory depression. A review.J Clin Psychiatry1981; 42: 368–373.
5.
LauerJ.W., InstripW.M., BernsohnJ.. Observations on schizophrenic patient after iproniazid and tryptophan.AMA Archives Neurol-Psychiatry1958; 80: 122–130.
6.
OatesJ.A., SjoerdsmaH.Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor.Neurology1960; 10: 1076–1078.
7.
PareC.M.B.Potentiation of monoamine oxidase inhibitors by trytophan.Lancet1963; 2: 527–528.
8.
GlassmanA.H., PlatmanS.R.Potentiation of monoamine oxidase inhibitor by tryptophan.J Psychiatr Res1969; 7: 83–88.
9.
ThomasJ.M., RubinE.H.Case report of a toxic reaction from a combination of tryptophan and phenelzine.Am J Psychiatry1984; 141(2): 281–283.