One hundred and eleven inpatients with schizophrenia and 51 with other psychiatric conditions were compared for the frequency of rheumatoid arthritis, other connective tissue disorders and other physical illness. Evidence both of rheumatoid arthritis and osteoarthritis was significantly less in the schizophrenia group. Latex Agglutination Tests were positive to the same extent in both groups. One possible explanation of the findings is that they are due to the reduced frequency of trauma or stress to the joints in schizophrenic inpatients, many of whom lived in hospital, compared with the control group. Other explanations are also considered.
References
1.
NissenH.A., SpencerK.A.The psychogenic problem (endocrinal and metabolic) in chronic arthritis.N Engl J Med1936; 214: 576–81.
2.
GreggD.The paucity of arthritis among psychotic cases.Am J Psychiatry1939; 95: 853–8.
3.
RossW.D., HayJ., McDowallM.F.The incidence of certain vegetative disturbances in relation to psychosis.Psychosom Med1950; 12: 179–83.
4.
TrevathanR.D., TatumJ.C.Rarity of concurrence of psychosis and rheumatoid arthritis in individual patients.J Nerv Ment Dis1954; 120: 83–4.
5.
PilkingtonT.L.The coincidence of rheumatoid arthritis and schizophrenia.J Nerv Ment Dis1956; 124: 604–6.
6.
MellsopG.W., KoadlowL., SymeJ., WhittinghamS.Absence of rheumatoid arthritis in schizophrenia.Aust NZ J Med1974; 4: 247–52.
7.
CheckleyS.A., BirleyJ.I.T.Schizophrenia and rheumatoid arthritis.The Lancet1977; i: 1258–9.
8.
OsterbergE., OlhagenB., WetterbergL.Schizophrenia and rheumatoid arthritis.The Lancet1977; i: 1367.
9.
OsterbergE.Schizophrenia and rheumatic disease — a study on the concurrence of inflammatory joint diseases and a review of 58 case-records.Acta Psychiatr Scand1978; 58: 339–59.
10.
American Rheumatism Association: primer on the rheumatic diseases.Prepared by a committee of the American Rheumatism Association section of the Arthritis Foundation, 7th edition. Reprinted from Am J Med Assoc 1973; 224(5) (Suppl.) RodnamG.P., McEwanC., WallaceS.L. eds. New York: Distributed in Canada through the Canadian Arthritis and Rheumatism Society.
11.
HorrobinD.F., AllyA.I., KarmaliR.A.,Prostaglandins and schizophrenia: further discussion of the evidence.Psychol Med1978; 8: 43–8.
12.
ColtonT.Fallacies in numerical reasoning. In: Statistics in medical research.Boston, Mass.: Little, Brown and Company,1974: 305–55.
13.
MankinH.J.The reaction of articular cartilage to injury and osteoarthritis.N Engl J Med 1974; 291(24): 1285–92 and1974; 291(25): 1335–40.
14.
SokoloffL.On the pathology and pathogenesis of osteoarthritis. In: McCartyD.J. ed. Arthritis and allied conditions, 9th. ed.Philadelphia: Lea and Febiger,1979: 1135–53, Chapter 73.
15.
JulkunenH., RasanenJ.A., KatajaJ.Severe trauma as an etiological factor in rheumatoid arthritis.Scand J Rheumatol1974; 3: 97–102.
