The literature regarding the association of psychosis and/or neuroleptic medication with sudden, unexpected, “autopsy negative” death is surveyed. Richardson's work is reviewed; in particular his conclusion that acid muco-polysaccharide deposition in the cardiovascular systems of his patients was of etiologic significance in their deaths.
A case report follows which supports the association of psychosis and neuroleptic intake with abnormal muco-polysaccharide deposition and sudden death.
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