Psychiatric disorder in relation to Klinefelter's syndrome is reviewed. A well documented case report is presented of a schizophreniform illness in a patient with Klinefelter's.
References
1.
KlinefelterH.F., RifensteinE., AlbrightR.Syndrome characterized by gynaecomastia, aspermatogenesis with a-Leydigism; and increased excretion of follicle stimulating hormone.J Clin Endocrinol1942; 615–27.
2.
CaldwellP.D., SmithD.W.The XXY (Klinefelter's) syndrome in childhood: detection and treatment.J Pediatr1972; 80: 250–58.
3.
Ferguson-SmithM.A.The prepubertal testicular lesion in chromatin-positive Klinefelter's syndrome (primary micro-orchidism) as seen in mentally handicapped.Lancet1959; i: 219–22.
4.
AnnellA.L., GustavsonK.H., TenstamJ.Symptomatology in schoolboys with positive sex chromatin (the Klinefelter syndrome).Acta Psychiatr Scand1970; 46: 71–80.
5.
ForssmanH.The mental implications of sex chromosome aberrations.Br J Psychiatry1970; 117: 353–63.
6.
FrolandA.Klinefelter's syndrome. In: Clinical, endocrinological and cytogenetical studies. Danish Medical Bulletin1969; Suppl. 16.
7.
MacleanN., Court-BrownW.M., JacobsD.A., MantleD.J., StrongJ.A.A survey of sex chromatin abnormalities in mental hospitals.J Med Genet1968; 5: 165–72.
8.
NielsenJ., SillesenI.Follow-up till age 3–4 of unselected children with sex chromosome abnormalities.Hum Genet1976; 33: 241–57.
9.
NielsenJ., JohnsonS., SorensenK.Follow-up 10 years later of 34 Klinefelter males with karyotype 47, XXY and 16 hypogonadal males with karyotype 46, XY.Psychol Med1980; 10: 345–52.
10.
SwansonD.W., StipesA.H.Psychiatric aspects of Klinefelter's syndrome.Am J Psychiatry1969; 126: 814–22.
11.
WakelingA.Comparative study of psychiatric patients with Klinefelter's syndrome and hypogonadism.Psychol Med1972; 2: 139–54.
NielsenJ.Criminality among patients with Klinefelter's syndrome and the XYY syndrome.Br J Psychiatry1970; 117: 365–69.
19.
BarkerT., BlackW.Klinefelter's syndrome in a military population.Arch Gen Psychiatry1976; 33: 607–10.
20.
BablokL., JanczewskiZ.Early and late results of treatment of Klinefelter's syndrome with positive type of sex chromatin.Polish Endocrinology1969; 20: 6–11.
21.
BeckerK.L.Clinical and therapeutic experience with Klinefelter's syndrome.Fertil Steril1972; 23: 568–78.
22.
Beaumont PJV, Bancroft JHJ, BeardwoodC.J., RussellG.F.M.Behavioural changes after treatment with testosterone : case report.Psychol Med1972; 2: 70–72.
23.
JohnsonC.F.Management of Klinefelter's syndrome.Clin Pediatr1975; 14: 534–44.
24.
MyhreS.A., RuvalcabaR.H.A., JohnsonH.R., ThulineH.C., KelleyV.C.The effects of testosterone treatment in Klinefelter's syndrome.J Pediatr1970; 76: 267–76.
