Biochemistry of Mental Depression *

Åsberg M. ; “Serotonin depression” — a biochemical subgroup within the affective disorders? 10th Cong. Collegium Internationale Neuro-Psychopharmacologicum, Quebec, July 1976 (p. 24).

Åsberg M. , Thorén P. , Träskman L. : “Serotonin depression” — a biochemical subgroup within the affective disorders? Science 191: 479–480, 1976.

Åsberg M. , Träskman L. , Thorén P. : 5-HIAA in the cerebrospinal fluid. Arch Gen Psychiatry 33: 1193–1197, 1976.

Ashcroft G. W. , Blackburn I.M. , Eccleston D. , Glen A.I.M. , Hartley W. , Kinloch N.E. , Lonergan M. , Murray L.G. , Pullar I.A. : Changes on recovery in the concentrations of the biogenic amines in the CSF of patients with affective illness. Psychol Med 3: 319–325, 1973.

Ashcroft G.W. , Eccleston D. , Knight F. , McDougall E.J. , Waddell J.L. : Changes in amine metabolism produced by antidepressant drugs. J. Psychosom Res 9: 129–136, 1965.

Aylward M. , Maddock M. : Plasma tryptophan levels in depression. Lancet i: 936, 1973.

Badawy A.A.B. , Evans M. : The mechanism of inhibition of rat liver tryptophan pyrrolase activity by 4-hydroxypyrazolo (3,4-d) pyrimidine (allopurinol). Biochem J 133: 585–591, 1973.

Beckmann H. , Goodwin F.K. : Antidepressant reponse to tricyclics and urinary MHPG in unipolar patients. Arch Gen Psychiatry 32: 17–21, 1975.

Birkmayer W. , Neumayer E. : Die Behandlung der Dopa-Psychosen mit L-Tryptophan. Nervenarzt 43: 76–78, 1972.

Bourne H.R. , Bunney W.E. Jr. , Colburn R.W. , Davis J.M. , Davis J.N. , Shaw D.M. , Coppen A.J. : Noradrenaline, 5-hydroxytryptamine, and 5-hydroxy-indoleacetic acid in hindbrains of suicidal patients. Lancet ii: 805–808, 1968.

Brodie B.B. , Spector S. , Shore P.A. : Interaction of drugs with norepinephrine in the brain. Pharmacol Rev 11: 548–564, 1959.

Brooksbank B.W.L. , Coppen A. : Plasma 11-hydroxycorticosteroids in affective disorders. Br J Psychiatry 113: 395–404, 1967.

Casper R.C. , Davis J.M. , Pandey G.N. , Garver D.L. , Dekirmenjian H. : Neuroendocrine and amine studies in affective illness. Psychoneuroendocrinology 2: 105–113, 1977.

Chouinard G. , Young S.N. , Annable L. , Sourkes T.L. : Tryptophan-nicotinamide combination in depression. Lancet i: 249, 1977.

Cochran E. , Robins E. , Grote S. : Regional serotonin levels in brain: a comparison of depressive suicides and alcoholic suicides with controls. Biol Psychiatry 11: 283–294, 1976.

Cohn C.K. , Dunner D.L. , Axelrod J. : Reduced catechol-O-methyltransferase activity in red blood cells of women with primary affective disorder. Science 170: 1323–1324, 1970.

Coppen A. : The biochemistry of affective disorders. Br J Psychiatry 113: 1237–1264, 1967.

Coppen A. : Indoleamines and affective disorders. J Psychiatr Res 9: 163–171, 1972.

Coppen A. , Brooksbank B.W.L. , Noguera R. , Wilson D.A. : Cortisol in the cerebrospinal fluid of patients suffering from affective disorders. J Neurol Neurosurg Psychiatry 34: 432–435, 1971.

Coppen A. , Brooksbank B.W.L. , Peet M. : Tryptophan concentration in the cerebrospinal fluid of depressive patients. Lancet i: 1393, 1972.

Coppen A. , Eccleston E.G. , Peet M. : Total and free tryptophan concentration in the plasma of depressive patients. Lancet ii: 60–63, 1973.

Curzon G. : Tryptophan pyrrolase: a biochemical factor in depressive illness? Br J Psychiatry 115: 1367–1374, 1969.

Curzon G. : Effects of adrenal hormones and stress on brain serotonin. Am J Clin Nutr 24: 830–833, 1971.

Curzon G. : Relationships between stress and brain 5-hydroxytryptamine and their possible significance in affective disorders. J Psychiatr Res 9: 243–252, 1972.

Deleon-Jones F. , Maas J.W. , Dekirmenjian H. , Sanchez J. : Diagnostic subgroups of affective disorders and their urinary excretion of catecholamine metabolites. Am J Psychiatry 132: 1141–1148, 1975.

Doig R.F. , Mummery R.V. , Wills M.R. , Elkes A. : Plasma Cortisol levels in depression. Br J Psychiatry 112: 1263–1267, 1966.

Dunner D.L. , Cohn C.K. , Gershon E.S. , Goodwin F.K. : Differential catechol-O-methyltransferase activity in unipolar and bipolar affective illness. Arch Gen Psychiatry 25: 348–353, 1971.

Dunner D.L. , Gershon E.S. , Goodwin F.K. : Heritable factors in the severity of affective illness. Biol Psychiatry 11: 31–42, 1976.

Ehrensing R.H. , Kastin A.J. : Melanocyte-stimulating hormone-releasing inhibiting hormone as an antidepressant. Arch Gen Psychiatry 30: 63–65, 1974.

Etienne P. , Young S.N. , Sourkes T.L. : Inhibition by albumin of tryptophan uptake by rat brain. Nature 262: 144–145, 1976.

Fernstrom J.D. , Wurtman R.J. : Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 173: 149–152, 1971.

Gershon E.S. , Jonas W.Z. : Erythrocyte soluble catechol-O-methyltransferase activity in primary affective disorder. Arch Gen Psychiatry 32: 1351–1356, 1975.

Gessa G.L. , Tagliamonte A. : “Serum free tryptophan: control of brain concentrations of tryptophan and of synthesis of 5-hydroxytryptamine” in Aromatic Amino Acids in the Brain. Edited by Wolstenholme G.E.W. , and Fitzsimons D.W. Ciba Foundation Symposium 22 (new series); Amsterdam: Elsevier, Excerpta Medica, North-Holland Associated Scientific Publishers, 1974.

Goodwin F.K. : Antidepressant response CSF drug levels and amine metabolites. 10th Cong. Collegium Internationale Neuro-Psychopharmacologicum, Quebec, July 1976 (p. 23).

Goodwin F.K. , Murphy D.L. , Brodie H.K.H. , Bunney W.E. Jr. : L-Dopa, catecholamines, and behavior: a clinical and biochemical study in depressed patients. Biol Psychiatry 2: 341–366, 1970.

Goodwin F.K. , Post R.M. , Dunner D.L. , Gordon E.K. : Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique. Am J Psychiatry 130: 73–79, 1973.

Gold P.W. , Goodwin F.K. , Rebar R. , Wehr T. : “Neuroendocrine responses in affective illness.” Scientif. Proc. Am. Psychiat. Assoc, 130th Ann. Meet., Toronto, May 1977.

Grote S.S. , Moses S.G. , Robins E. , Hudgens R.W. , Croninger A.B. : A study of selected catecholamine metabolizing enzymes: a comparison of depressive suicides and alcoholic suicides with controls. J Neurochem 23: 791–802, 1974.

Johansson C. , Allgén L.G. , Hellstrom L. : Tryptophan concentration in serum of patients with regional enteritis: its probable relation to depression. Acta Med Scand 194: 551–552, 1973.

Joseph M.H. , Young S.N. , Curzon G. : The metabolism of a tryptophan load in rat brain and liver: the influence of hydrocortisone and allopurinol. Biochem Pharmacol 25: 2599–2604, 1976.

Kastin A.J. , Schalch D.S. , Ehrensing R.H. , Anderson M.S. : Improvement in mental depression with decreased thyrotropin-response after administration of thyrotropin-releasing hormone. Lancet ii: 740–742, 1972.

Kirkegaard C. , Bjorum N. , Cohn D. , Faber J. , Lauridsen U.B. , Nerup J. : Studies on the influence of biogenic amines and psychoactive drugs on the prognostic value of the TRH stimulation test in endogenous depression. Psychoendocrinology 2: 131–136, 1977.

Kripke D.F. : Serotonin depression. Science 194: 214, 1976.

Landowski J. , Lysiak W. , Angielski S. : Monoamine oxidase activity in blood platelets from patients with cyclophrenic depressive syndromes. Biochem Med 14: 347–354, 1975.

Lapin I.P. , Oxenkrug G.F. : Intensification of the central serotonergic process as a possible determinant of the thymoleptic effect. Lancet i: 132–136, 1969.

Lehmann J. : Mental and neuromuscular symptoms in tryptophan deficiency. Acta Psychiat Scand Suppl. 237: 5–28, 1972.

Lehmann J. : Tryptophan malabsorption in levodopa-treated parkinsonian patients. Acta Med Scand 194: 181–189, 1973.

Lloyd K.G. , Farley I.J. , Deck J.H.N. , Hornykiewicz O. : Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients. Adv Biochem Psychopharmacol 11: 387–397, 1974.

Loosen P.T. , Prange A.J. Jr. , Wilson I.C. , Lara P.P. , Pettus C. : Thyroid stimulating hormone response after thyrotropin releasing hormone in depressed, schizophrenic and normal women. Psychoneuroendocrinology 2: 137–148, 1977.

Maas J.W. , Dekirmenjian H. , Fawcett J.A. : MHPG excretion by patients with affective disorders. Int Pharmacopsychiatry 9: 14–26, 1974.

Maas J.W. , Fawcett J.A. , Dekirmenjian H. : Catecholamine metabolism, depressive illness, and drug response. Arch Gen Psychiatry 26: 252–262, 1972.

M.R.C. Brain Metabolism Unit: Modified amine hypothesis for the aetiology of affective illness. Lancet ii: 573–577, 1972.

Moses S.G. , Robins E. : Regional distribution of norepinephrine and dopamine in brains of depressive suicides and alcoholic suicides. Psychopharmacol Commun 1: 327–337, 1975.

Murphy D.L. , Brodie H.K.H. , Goodwin F.K. , Bunney W.E. Jr. : Regular induction of hypomania by L-Dopa in “bipolar” manic-depressive patients. Nature 229: 135–136, 1971.

Murphy D.L. , Costa J.L. : “Utilization of cellular studies of neurotransmitter-related enzymes and transport processes in man for the investigation of biological factors in behavioral disorders” in The Psychobiology of Depression. Edited by Mendels J. . Chapter 3, pp. 27–46; New York: Spectrum Publications, 1975.

Murphy D.L. , Slater S. , de la Vega E. : The serotonergic neurotransmitter system in the affective disorders — an evaluation of the antidepressant and antimanic effects of fenfluramine. Proc. 10th Cong. Collegium Internationale Neuro-Psychopharmacologicum, Quebec, July, 1976, (p. 125).

Murphy D.L. , Weiss R. : Reduced monoamine oxidase activity in blood platelets from bipolar depressed patients. Am J Psychiatry 128: 1351–1357, 1972.

Nies A. , Robinson D.S. , Lamborn K.R. : Genetic control of platelet and plasma monoamine oxidase activity. Arch Gen Psychiatry 28: 834–838, 1973.

Niskänen P. , Hüttunen M. , Tamminen T. , Jääskeläïnen J. : The daily rhythm of plasma tryptophan and tyrosine in depression. Br J Psychiatry 128: 67–73, 1976.

Nordin G. , Ottosson J.O. , Roos B.E. : Influence of convulsive therapy on 5-hydroxyindoleacetic acid and homo vanillic acid in cerebrospinal fluid in endogenous depression. Psychopharmacologia (Berlin) 20: 315–320, 1971.

Olson L. , Nyström B. , Seiger Å., : Monoamine fluorescence histochemistry of human postmortem brain. Brain Res 63: 231–247, 1973.

Paasonen M.K. , Ahtee L. , Solatunturi E. : Blood platelet as a model for monoaminergic neurons. Prog Brain Res 34: 269–279, 1971.

Pare C.M.B. , Rees L. , Sainsbury M.J. : Differentiation of two genetically specific types of depression by the response to anti-depressants. Lancet ii: 1340–1343, 1962.

Pare C.M.B. , Yeung D.P.H. , Price K. , Stacey R.S. : 5-hydroxytryptamine, noradrenaline, and dopamine in brainstem, hypothalamus, and caudate nucleus of controls and of patients committing suicide by coal-gas poisoning. Lancet ii: 133–135, 1969.

Pletscher A. ; Metabolism, transfer, and storage of 5-hydroxytryptamine in blood platelets. Br J Pharmacol 32: 1–16, 1968.

Post R.M. , Goodwin F.K. : “Studies of cerebrospinal fluid amine metabolites in depressed patients: conceptual problems and theoretical implications” in The Psychobiology of Depression, Chapter 4. Edited by Mendels J. , Toronto: Spectrum Publications, 1975.

Post R.M. , Kotin J. , Goodwin F.K. , Gordon E.K. : Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness. Am J Psychiatry 130: 67–72, 1973.

Prange A.J. Jr. , Wilson I.C. , Nox A.E. : Thyroid-imipramine clinical and chemical interaction: evidence for a receptor deficit in depression. J Psychiat Res 9: 187–205, 1972.

Prange A.J. Jr. , Wilson I.C. , Lara P.P. , Alltop L.B. , Breese G.R. : Effects of thyrotropin-releasing hormone in depression. Lancet ii: 999–1002, 1972.

Robinson D.S. : Changes in monoamine oxidase and monoamines with human development and aging. Fed Proc 34: 103–107, 1975.

Robinson D.S. , Davis J.M. , Nies A. : Relation of sex and aging to monoamine oxidase activity of human brain, plasma and platelets. Arch Gen Psychiatry 24: 536–539, 1971.

Robinson D.S. , Davis J.M. , Nies A. : Aging, monoamines, and monoamine oxidase levels. Lancet i: 290–291, 1972.

Robinson D.S. , Sourkes T.L. , Nies A. , Harris L.S. , Spector S. , Bartlett D.L. , Kaye I.S. : Monoamine metabolism in human brain. Arch Gen Psychiatry 34: 89–92, 1977.

Roos B.E. , Sjöström R.S. : 5-hydroxyindoleacetic acid (and homovanillic acid) levels in the cerebrospinal fluid after probenecid application in patients with manic-depressive psychosis. Pharmacologic Clinica 1: 153–155, 1960.

Rubin R.T. : Adrenal cortical activity changes in manic-depressive illness. Arch Gen Psychiatry 17: 671–679, 1967.

Rubin R.T. , and Mandell A.J. : Adrenal cortical activity in pathological emotional states. Am J Psychiatry 123: 387–400, 1966.

Sachar E.J. : “A neuroendocrine strategy in the psychobiological study of depressive illness” in The Psychobiology of Depression, Chapter 8, pp. 123–132. Edited by Mendels J. New York: Spectrum Publications, 1975.

Sachar E.J. , Hellman L. , Fukushima D.K. , Gallagher T.F. : Cortisol production in depressive illness. Arch Gen Psychiatry 23: 289–298, 1970.

Sack R.L. , Goodwin F.K. : Inhibition of dopamine β-hydroxylase in manic patients. Arch Gen Psychiatry 31: 649–654, 1974.

Sandler M. , Carter S.B. , Cuthbert M.F. , Pare C.M.B. : Is there an increase in monoamine-oxidase activity in depressive illness! Lancet i: 1045–1049, 1975.

Schildkraut J.J. : The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122: 509–522, 1965.

Schildkraut J. J. : Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: preliminary findings. Am J Psychiatry 130: 695–698, 1973.

Schildkraut J.J. : Biochemical criteria for classifying depressive disorders and predicting responses to pharmacotherapy: preliminary findings from studies of norepinephrine metabolism. Pharmakopsychiatrie 7: 98, 1974.

Schildkraut J.J. : Biogenic amines and affective disorders. Ann Rev Med 23: 333–348, 1974.

Schildkraut J.J. , Keeler B.A. , Papousek M. , Hartmann E. : MHPG excretion in depressive disorders: relation to clinical subtypes and desynchronized sleep. Science 181: 762–764, 1973.

Schildkraut J.J. , Kety S.S. : Biogenic amines and emotion. Science 156: 21–30, 1967.

Schwartz M.A. , Wyatt R.J. , Yang H.-Y.T. , Neff N.H. : Multiple forms of brain monoamine oxidase in schizophrenic and normal individuals. Arch Gen Psychiatry 31: 557–560, 1974.

Segal D.S. , Kuczenski R. , Mandell A.J. : Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder. Biol Psychiatry 9: 147–159, 1974.

Shaw D.M. : Mineral metabolism, mania, and melancholia. Br Med J ii: 262–267, 1966.

Shaw D.M. , Camps F.E. , Eccleston E.G. : 5-Hydroxytryptamine in the hindbrain of depressive suicides. Br J Psychiatry 113: 1407–1411, 1967.

Shaw D.M. , Johnson A.L. , Tidmarsh S.F. , MacSweeney D.A. , Hewland H.R. , Woolcock N.E. : Multicompartmental analysis of amino acids. I. Preliminary data on concentrations, fluxes and flow constants of tryptophan in affective illness. Psychol Med 5: 206–213, 1975.

Shopsin B. , Freedman L.S. , Goldstein M. , Gershon S. : Serum dopamines-β-hydroxylase (DβH) activity and affective states. Psychopharmacologia (Berlin) 27: 11–16, 1972.

Shopsin B. , Friedman E. , Gershon S. : Parachlorophenylanine reversal of tranylcypromine effects in depressed patients. Arch Gen Psychiatry 33: 811–822, 1976.

Shopsin B. , Friedman W. , Gershon S. : The use of synthesis inhibitors in defining a role for biogenic amines during tricyclic and MAO inhibitor therapy in depressed patients. Proc. 10th Cong. Collegium Internationale Neuro-Psychopharmacologicum, Quebec, July 1976 (p. 123).

Shopsin B. , Wilk S. , Sathananthan G. , Gershon S. , Davis K. : Catecholamines and affective disorders revised: A critical assessment. J Nerv Ment Dis 158: 369–383, 1974.

Sjöström R. : 5-Hydroxyindole acetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis and the effect of probenecid treatment. Eur J Clin Pharmacol 6: 75–80, 1973.

Sjöström R. , Roos B.E. : 5-Hydroxy-indoleacetic acid and homovanillic acid in cerebrospinal fluid in manic depressive psychosis. Eur J Clin Pharmacol 4: 170–176, 1972.

Sourkes T.L. : “Parkinson's disease and other disorders of the basal ganglia” in Basic Neurochemistry. Edited by Siegel G.J. , Albers R.W. , Katzman R. , and Agranoff B.W. 2nd edition, Chapter 32, pp. 668–684, Boston: Little Brown and Co., 1976.

Sourkes T.L. : “Psychopharmacology and biochemical theories of mental disorders” in Basic Neurochemistry. Edited by Siegel G.J. , Albers R.W. , Katzman R. , and Agranoff B.W. 2nd edition, Chapter 34, pp. 705–736, Boston: Little Brown and Co., 1976.

Sourkes T.L. : Neurotransmitters of the human brain, and their relationships. Proc. 10th Cong. Collegium Internationale Neuro-Psychopharmacologicum, Quebec, July 1976.

Spano P.F. , Andreoli V. , Tonon G.C. , Sirtori C.R. : Plasma tryptophan transport in normal and depressed subjects. Med Biol 53: 489–492, 1975.

Tsuang M.T. : “Genetics of affective disorder” in The Psychobiology of Depression. Edited by Mendels J. Chapter 6, pp. 85–100, New York: Spectrum Publications, 1975.

Tuomisto J. , Tukiainen E. : Decreased uptake of 5-hydroxytryptamine in blood platelets from depressed patients. Nature 262: 596–598, 1976.

van Kempen G.M.J. , Vrensen G.F.J.M. : Biochemical and morphological integrity of subcellular organelles from human postmortem brain. Neurobiology 4: 12–20, 1974.

van Praag H.M. : Significance of biochemical parameters in the diagnosis, treatment and prevention of depressive disorders. Biol Psychiatry 12: 101–131, 1977.

van Praag H.M. , Korf J. : Retarded depression and the dopamine metabolism. Psychopharmacologia (Berlin) 19: 199–203, 1971.

van Praag H.M. , Korf J. : Cerebral monoamines and depression Arch Gen Psychiatry 28: 827–831, 1973.

van Praag H.M. , Korf J. : Serotonin metabolism in depression: clinical application of the probenecid test. Int Pharmacopsychiatry 9: 35–51, 1974.

van Praag H.M. , Korf J. , van Woudenberg F. , Kits T.P. : An attempt at indirect evaluation of the noradrenaline hypothesis. Psychiatria, Neurologia, Neurochirurgia 72: 181–187, 1969.

Wetterberg L. , Aberg H. , Ross S.B. , Froden O. : Plasma dopamine-beta-hydroxylase activity in hypertension and various neuropsychiatric disorders. Scand J Clin Lab Invest 30: 283–289, 1972.

Wirz-Justice A. , Puhringer W. , Hole G. , Menzi R. : Monoamine oxidase and free tryptophan in human plasma: normal variations and their implications for biochemical research in affective disorders. Pharmakopsychiatrie 8: 310–317, 1975.

Wyatt R.J. , Murphy D.L. , Belmaker R. : Reduced monoamine oxidase activity in platelets: a possible genetic marker of vulnerability to schizophrenia. Science 179: 916–918, 1973.

Young S.N. , Sourkes T.L. : Antidepressant action of tryptophan. Lancet ii: 897–898, 1974.

Young S.N. , Sourkes T.L. : Tryptophan in the central nervous system: regulation and significance. Adv Neurochem 2: 133–191, 1977.