A single case of Stiff-man Syndrome is presented. Some of the literature relevant to this syndrome is reviewed and the presenting clinical features and associated laboratory findings are briefly summarized. Differential diagnosis and recent views on the mechanism of the disorder are also discussed. The case was reported because of its relevance to psychiatry in that the majority of patients with Stiff-man Syndrome present with non-specific psychiatric symptoms such as depression and anxiety. They are often labeled as neurotic or hysterical and frequently come to the attention of psychiatrists long before the diagnosis is made, but once the diagnosis is made treatment is both specific and effective.
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