Levels of three classes of immunoglobulins, Ig G, Ig A and Ig M, were determined in a group of carefully selected, drug-free, psychiatric patients. Significant elevation of Ig M occurred in female patients as compared to controls but did not occur in males. This elevation did not appear to be related to schizophrenia. There was also an apparent relationship between severe disorganizing levels of anxiety and increased Ig A values.
References
1.
BardenJ., MullinaxF., and WallerM.: Immunoglobulin levels in rheumatoid arthritis: Comparison with rheumatoid factor titres, clinical stage and disease duration.Arthritis and Rheum.10: 228–233, 1967.
2.
BeckettP. G. S., GrisellJ., CrandallR. G., and GudobbaR.: A method of formalising psychiatric study.Arch. Gen. Psychiat.16: 407–415, 1967.
3.
BishopM. P., HollisterL. E., GallantD. M., and HeathR. G.: Ultra centrifugal serum proteins in schizophrenia.Arch. Gen. Psychiat.15: 337–339, 1966.
ButterworthM., McClellanB., and AllansmithM.: Influence of sex on immunoglobulin levels.Nature,214: 1124–1125, 1967.
6.
ClamanH. N., and NerrillD.: Serum immunoglobulins in rheumatoid arthritis.J. Lab. Clin. Med.67: 850–854, 1966.
7.
FaheyJ. L., and McKelveyE. M.: Quantitative determination of serum immunoglobulins in antibody-agar plates.J. Immun.94: 84–90, 1965.
8.
FesselW. J.: Disturbed serum proteins in chronic psychosis; Serological, medical and psychiatric correlations.Arch. Gen. Psychiat.4: 154–159, 1961.
9.
FesselW. J.: Mental stress, blood proteins and the hypothalamus.Arch. Gen. Psychiat.7: 427–435, 1962.
10.
HeathR. G., and KruppI. M.: Schizophrenia as an immunological disorder. Parts I, II, and III.Arch. Gen. Psychiat.16: 1–34, 1967.
11.
JensenK., ClausenJ., and OstermanE.: Serum and cerebrospinal fluid proteins in schizophrenia.Acta Psychiat. Scand.40: 280–286, 1964.
12.
ManciniG., CarbonaroA. O., and HeremansJ. F.: Immunochemical quantitation of antigens by single radial immuno diffusion.Immunochem.2: 235–254, 1965.
13.
SchneiderK.: Clinical Psychopathology. Transl, by Hamilton, M. W. New York: Grune and Stratton, 88–144, 1959.
14.
SolomonG. F., AllansmithM., McClellanB., and AmkrautA.: Immunoglobulins in psychiatric patients.Arch. Gen. Psychiat.20: 272–277, 1969.
15.
StabenauJ. R., PollinW., and MosherL.: Serum macroglobulins (S19) in families of monozygotic twins discordant for schizophrenia.Amer. J. Psychiat.125: 109–112, 1968.
16.
StephensJ. H., AstrupC., and MangrumJ. C.: Prognosis in schizophrenia. Prognostic scales cross-validated in American and Norwegian patients.Arch. Gen. Psychiat.16: 693–698, 1967.
