Biochemistry of Depression *

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Coppen A. , Ecceleston E. and Gundy G. : Tryptamine metabolism in depression Brit. J. Psychiat. 111: 993, 1965.

Coppen A. , Shaw D. M. , Herzberg B. and Maggs R. : Tryptophan in the treatment of depression Lancet ii: 1178-1180, 1967.

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Gibbons J. L. and McHugh P. R. : Plasma Cortisol in depressive illness J. Psychiat. Res. 162-171, 1962.

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Jouvet M. : Insomnia and decrease of cerebral 5-Hydroxytryptamine after destruction of the Raphé system in the cat. Adv. in Pharmacol. 6B, 265-282, 1968.

Klerman G. L. , Schildkraut J. J. , Hasenbush L. L. , Greenblatt M. and Friend D. G. : Clinical experience with dihydroxy-phenylalanine (DOPA) in depression J. Psychiat. Res. 1: 289, 1963.

Knox W. E. and Auerbach V. H. : Hormonal control of tryptophan peroxidase in rat. J. Biol. Chem. 124: 307-313, 1955.

Knox W. E. , Piras M. M. and Tokuyama J. : Induction of tryptophan pyrrolase in rat liver by physiological amounts of hydrocortisone and secreted glucocorticoids. Enzym. Biol. Clin. 7: 1-10, 1966.

Kurland G. S. and Freedberg A. S. : The potentiating effect of ACTH and of cortisone pressor response to intravenous infusion of L-norepinephrine. Proc. Soc. Exp. Biol. Med. 78: 28-31, 1951.

Lapin I. P. and Oxenkrug G. F. : Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect. Lancet, i: 132-136, Jan. 18, 1969.

Lemieux G. , Davignon H. and Genest J. : Depressive states during rauwolfia therapy for arterial hypertension Canad. Med. Ass. J. 74: 522, 1956.

Lipton Morris A. : Editorial: Affective disorders — Progress, but some unresolved questions remain. Amer. J. Psychiat. 127 357-358, 1970.

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Moir A. T. B. and Eccleston D. : The effects of precursor loading in the cerebral metabolism in 5-Hydroxyindoles J. Neurochem. 15: 1093-1108, 1968.

McClure D. J. : The diurnal variation of plasma Cortisol levels in depression J. Psychosom. Res. 10: 189-195, 1966.

McClure D. J. : Discussion — A peripheral decarboxylase inhibitor in depression Amer. J. Psychiat. 1970.

Persky H. : Adrenocortical function in anxious human subjects: The disappearance of hydrocortisone from plasma and its metabolic fate J. Clin. Endoc. 17: 760-765, 1957.

Prange A. J. Jr., Wilson I. C. , Rabon A. M. and Lipton M. A. : Enhancement of imipramine by triiodothyronine in unselected depressed patients. Excerpta Med. Internl. Congress Series, 180: 532-535, April 1968.

Prange A. J. Jr.: Wilson I. C. , Rabon A. M. and Lipton M. A. : Enhancement of imipramine antidepressant activity by thyroid hormone. Amer. J. Psychiat. 126: 457-469, 1969.

Ramey E. R. and Goldstein M. S. : The adrenal cortex and the sympathetic nervous system. Physiol. Rev. 37: 155-195, 1957.

Roos B. E. and Werdinius B. : Effect of reserpine on the level of 5-Hydroxyindo-leacetic acid in brain. Life Sci. 3: 105-107, 1962.

Sachar E. J. : Corticosteroids in depressive illness II: A longitudinal psychoendocrine study Arch. Gen. Psychiat. 17: 544-567, 1967.

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Shaw D. M. , Camps F. and Eccleston E. G. : 5-Hydroxytryptamine in the hindbrain of depressive suicides Brit. J. Psychiat. 113: 1407, 1967.

Sourkes T. L. , Missala K. and Madras B. K. : Effect of yohimbine on trytophan metabolism J. Pharmacol. 165: 289-293, 1969.

Weil-Malherbe H. The effect of convulsive therapy on plasma adrenaline and and noradrenaline J. Ment. Sci. 101: 156-162, 1955.

Wurtman R. J. and Axelrod J. : Adrenal synthesis: Control by the pituitary gland and adrenal glucocorticoids. Science 150: 1464-1465, 1965.