The pertinent literature on prochlorperazine has been reviewed. Prochlorperazine appears to be a useful drug in maintaining psychiatric patients in the community, following discharge from the mental hospital.
References
1.
AdelsonD., and EpsteinL. J.: A study of phenothiazines with male and female chronically ill schizophrenic patients.J. Nerv. Ment. Dis., 134(6): June 1962, 543–554.
2.
AydF. J.Jr.,: Drug-induced extrapyramidal reactions: Their clinical manifestations and treatment with Akineton.Psychosomatics1(3): May-June 1960, 143–150.
3.
BarsaJ. A.: Use of chlorpromazine combined with prochlorperazine.Amer. J. Psychiat., 114(12): 1112–1113, June 1958.
4.
BattiataS. V., and O'ReillyW. R.: Untoward reactions following the use of prochlorperazine (Compazine): A report of two cases.Clin. Proc. Child Hosp.15(6): June 1959, pp. 147–150.
5.
BenjaminF. B.: Effect of a tranquillizing agent on galvanic skin response.J. Appl. Physiol.11(2): September 1957, pp. 216–218.
6.
Borel: Essais thérapeutiques avec deux dérivés des phénothiazines, 4632 R.P. (Mopazine) et le 6140 R.P. (Stémetil). Therapeutic trials with two phenothiazine derivatives, RP 4632 (Mopazine) and RP 6140 (Stemetil).Ann. Méd. Psychol.115(1:3): 526–529, March 1957.
7.
BoydE. M.: Antiemetic action of prochlorperazine.Canad. Med. Ass. J., 76 (4): 286–289, February 15, 1957.
8.
BrodyI. A.: Shock after administration of prochlorperazine in patient with pheochromocytoma: Report of a case with spontaneous tumour destruction.J.A.M.A., 169(15): 1749–1752, April 11, 1959.
9.
BroussolleP.: La prochlorperazine en psychiatrie, expérience tirée de 240 cures. (Prochlorperazine in psychiatry, experience in 240 cases).Presse méd.65(73): 1628–1631, October 1957.
ClayR. C., and BoltonJ. W.: Tetanus arising from gangrenous unperforated small intestine.JAMA, 187(11): 856–858, March 14, 1964.
12.
CookL.: Evaluation of the activity of a group of centrally acting agents.J. Pharmacol. Exp. Ther.122(1): 14A–15A, January 1958.
13.
CourvoisierS.: Propriétés pharmacodynamiques générales de la prochlorpérazine (6.140 R.P.). (General pharmacodynamic properties of prochlorperazine RP 6140.C.R. Soc. Biol.151(6): 144–148, June 22, 1957.
14.
CraftM.: Mental disorder in the defective: the use of tranquillizers.Amer. J. Ment. Defic.64(1): 63–71, July 1959.
15.
CytrynL.: The effectiveness of tranquillizing drugs plus supportive psychotherapy in treating behavior disorders of children: a double-blind study of eighty outpatients.Amer. J. Orthopsychiat.30: 113–129, 1960.
16.
Dalsgaard-NielsenT.: Prochlorperazine in the prophylaxis of migraine.LancetII (7155): 877, October 15, 1960.
17.
DarlingH. F.: Fluphenazine: comparative studies.Dis. Nerv. Syst.21(7): 409–413, July 1960.
18.
DegennesL., and BricaireH.: Les accidents nerveux d'un nouvel antiémétique 6140 R.P.). (Neurological side effects of a new antiemetic RP 6140.Presse Méd.65(22): 499, March 16, 1957.
19.
DelayJ.: Nouveaux types d'accidents nerveaux dûs à un médicament neuroleptique, la prochlorpérazine. (New neurological complications caused by a neuroleptic drug, prochlorperazine).Ann. Médicopsychol. 115 (1:3): 510–514, March 1957; abstr. in Presse Méd.65(36): 859, May 4, 1957.
20.
DelayJ.: Similitude des accidents nerveux de la prochlorpérazine avec certains troubles post-encéphalitiques. (Similarity of neurological side effects of prochlorperazine to certain postencephalitis disorders).Ann. Médicopsychol.115(1:3): 506–510, March 1957.
21.
DenberH. C. B.: Some preliminary results with a new phenothiazine derivative: prochlorperazine.Psychiat, Res. Rep. No. 9, pp. 16–22, March 1958.
22.
DenhamJ.: The use of prochlorperazine (Stemetil) in chronic psychotic disorders.J. Ment. Sc.104(437): 1190–1194, October 1958.
23.
DillonH., and LeopoldR. L.: Children and the post-concussion syndrome.J.A.M.A.175(2): 86–92, January 14, 1961.
24.
DransfieldG. A.: A clinical trial comparing prochlorperazine (Stemetil) with chlorpromazine (Largactil) in the treatment of chronic psychotic patients.J. Ment. Sc.104(437): 1183–1189, October 1958.
25.
DruckmanR.: Chronic involuntary movements induced by phenothiazines.J. Nerv. Ment. Dis.135(1): 69–76, July 1962.
26.
DucrotR., and KoetschetP.: Propriétés antiémétiques d'un nouveau dérivé de la phénothiazine, la chloro-3 (N-methyl-piperazinyl-3-propyl)-10 phénothiazine (R.P. 6140). (Antiemetic properties of a new phenothiazine derivative, the 2-chloro-10-(3-N-methylpiperazinylpropyl) phenothiazine (R.P. 6140 - SKF 4657-I2). XXth International Physiological Congress-Brussels, July 30—August 4, 1956 — I-Abstracts of Communications, p. 258.
27.
EhrlichR. M.: A neurological complication in children on phenothiazine tranquillizers.Canad. Med. Ass. J.81(4): 241–243, August 15, 1959.
28.
FischerA., and GottreichN. S.: Anemia as a complication of prochlorperazine therapy.Amer. J. Psychiat.116(10): 932–933, April 1960.
29.
FreedH.: Reading disability: a new therapeutic approach and its implications.J. Clin. Exp. Psychopath.20(3): 251–259, July-September 1959.
30.
FreedH., and FrignitoN.: Tranquillizers in child psychiatry: current status on drugs, particularly phenothiazines.Pennsylvania Psychiat. Q.1(4): 39–48, Fall 1961.
31.
FreyhanF. A.: The neuroleptic action and effectiveness of prochlorperazine in psychiatric disorders.Psychiat. Res. Rep. No. 9, pp. 32–45, March 1958.
32.
FriendD. G., and McLemoreG. A.Jr.: Antiemetic properties of a new chlorphenothiazine derivative, prochlorperazine.AMA Arch. Int. Med.99(5): 732–735, May 1957.
33.
GalbraithA. J.: Stemetil in the treatment of chronic psychotics.J. Ment. Sc.105(438): 256–259, January 1959.
34.
GoldmanD.: Effect of prochlorperazine (Compazine) on psychotic states.Psychiat. Res. Rep. No. 9, pp. 23–31, March 1958.
35.
GrayW. D.: An appraisal of a new antiemetic drug: prochlorperazine.Internat. Rec. Med.170(8): 469–472, August 1957.
36.
HagenbachC.: Prochlorperazine in the prophylaxis of migraine.Practitioner184(1102): 503–506, April 1960.
37.
HamiltonM.: A controlled trial on the value of prochlorperazine, trifluoperazine and intensive group treatment.Brit. J. Psychiat.109(461): 510–522, July 1963.
38.
HanlonT. E.: Chlorpromazine, triflupromazine and prochlorperazine in chronic psychosis.AMA Arch. Gen Psychiat.1(2): 223–227, August 1959.
39.
HollisterL. E.: Unexpected asphyxiai death and tranquillizing drugs.Amer. J. Psychiat.114(4): 366–367, October 1957.
40.
HolmanW. T.: High dosage Compazine in chronic schizophrenia. DM.Nerv. Syst.19(7): 309–310, July 1958.
41.
IllingworthR. S., and HarveyC. C.: Prevention of migraine in children by prochlorperazine.LancetI (7116): 132, January 16, 1960.
42.
KellyE. L.: Personality differences and continued meprobamate and prochlorperazine administration.AMA Arch. Neural. Psychiat.80(2): 241–246, August 1958.
43.
KingP. D., and WeinbergerW.: Comparison of prochlorperazine and chlorpromazine in hospitalized chronic schizophrenics.Amer. J. Psychiat.115(11): 1026–1027, May 1959.
44.
KleinD. F., and FinkM.: Behavioral reaction patterns with phenothiazines.Arch. Gen. Psychiat.7(6): 449–459, December 1962.
45.
KlettC. J., and LaskyJ. J.: A clinical trial of five phenothiazines using sequential analysis.J. Clin. Exp. Psychopath.21(2): 89–100, April-June 1960.
46.
KlineN. S.: The use of prochlorperazine (Compazine) in a variety of psychiatric conditions.Psychiat. Res. Rep. No. 9, pp. 5–15, March 1958.
47.
KurlandA. A.: The comparative effectiveness of six phenothiazine compounds, phenobarbital and inert placebo in the treatment of acutely ill patients: personality dimensions.J. Nerv. Ment. Dis.134(1): 48–61, January 1962.
48.
LanzoniV.: Circulatory effects of intravenous prochlorperazine (Compazine) in humans.Fed. Proc.17(1): 386, March 1958.
49.
LecomteG.: Efficacité de la prochlorperazine à doses modérées dans les états d'excitation. (Efficacy of prochlorperazine at moderate doses in states of excitation).Ann. Méd. Psychol.115(1:5): 922–928, May 1957.
50.
LehmannH. E., and CsankJ.: Differential screening of phrenotropic agents in man: psychophysiologic test data.J. Clin. Exp. Psychopath.18(3): 222–235, September 1957.
51.
MackoE., and SteelmanR. L.: Acute, subacute and chronic toxicity of prochlorperazine (2-chloro-10- (3' (N-methylpiperazinyl-propyl) -phenothiazine) in mice, rats and dogs.Fed. Proc.17(1): 390, March 1958.
52.
MahrerP. R.: Atropine-like poisoning due to tranquillizing agents.Amer. J. Psychiat.115(4): 337–339, October 1958.
53.
MarksJ.: Predrug behavior as a predictor of response to phenothiazines among schizophrenics.J. Nerv. Ment. Dis.137(6): 597–601, December 1963.
54.
MayR. H.: Catatonic-like states following phenothiazine therapy.Amer. J. Psychiat.115(12): 1119–1120, June 1959.
55.
McAfoosL. G.Jr.: Prochlorperazine (Compazine) in emotional disturbances.Dis. Nerv. Syst.18(11): 430–433, November 1957.
56.
McFarlandR. B.: Fatal drug reaction associated with prochlorperazine (Compazine): report of a case characterized by jaundice, thrombocytopenia and agranulocytosis.Amer. J. Clin. Path.40(3): 284–290, September 1963.
57.
MendelW. M.: Observations on the comparative effects of tranquillizers on patients previously treated with prochlorperazine.Amer. J. Psychiat.115(5): 466–467, November 1958.
58.
MilneH. B., and BerlinerF.: A clinical trial of Stemetil (prochlorperazine).J. Ment. Sc.104(436): 873–879, July 1958.
59.
MilneJ.: The analysis of phenothiazine derivatives with tranquillizing properties.J. Amer. Pharm. Ass. Sc. Ed.48(2): 117–122, February 1959.
60.
MilnerH. B., and FowlerD. B.: A clinical trial of Largactil (chlorpromazine), Stemetil (prochlorperazine) and Veractil (methotrimeprazine).J. Ment. Sc.106(444): 1105–1110, July 1960.
61.
MitchellA. C.: Effects of prochlorperazine therapy on educability in disturbed mentally retarded adolescents.Amer. J. Ment. Defic.64(1): 57–62, July 1959.
62.
MoyerJ. H.: Effective antiemetic agents.Med. Clin. N. Amer.41(2): 405–432, March 1957.
63.
NelsonN. M.: Toxic hazards. Severe neurologic reactions to antiemetics.New England J. Med.260(25): 1296–1298. June 18, 1959.
64.
NobleR. C., and CastnerC. W.: Evaluation of prochlorperazine and a prochlorperazine-chlorpromazine combination in disturbed patients.Dis. Nerv. Syst.19(12): 531–533, December 1958.
65.
PeikesI. L.: Nausea and vomiting of pregnancy treated with a sustained release form of prochlorperazine.Clin. Med.4(11): 1385–1387, November 1957.
66.
PenningtonV. M.: Prochlorperazine in the treatment of the schizophrenias.Amer. J. Psychiat.115(9): 820–821, March 1959.
67.
PilkingtonT. L.: Prochlorperazine (Stemetil) in mental deficiency.J. Ment. Sc.105(438): 215–219, January 1959.
68.
RabinowitzP., and FriedmanI. S.: Drug-induced lactation in uremia.J. Clin. Endocr. Metab.21(11): 1489–1493, November 1961.
69.
RajotteP., and DenberH. C. B.: Long-term community follow-up of formerly hospitalized psychotic patients.J. Nerv. Ment. Dis.136(5): 445–454, May 1963.
70.
ReevesJ. E.: Successful prochlorperazine therapy following chlorpromazine-induced jaundice.California Med.87: 338–339, November 1957.
71.
RickelsK.: Evaluation of tranquillizing drugs in medical outpatients; meprobamate, prochlorperazine, amobarbital sodium and placebo.J.A.M.A.171(12): 1649–1656, November 21, 1959.
72.
RiesenmanF. R., and PettitM. B.: Clinical efficacy of prochlorperazine (Compazine) in mental illness.Amer. J. Psychiat.115(11): 1032–1033, May 1959.
73.
RobbH. P.: A comparison between prochlorperazine and chlorpromazine in mental deficiency.J. Ment. Sc.106(445): 1413–1416, October 1960.
74.
RobbieD. S.: Post-anaesthetic vomiting and antiemetic drugs.Anesthesia14(4): 349–354, October 1959.
75.
RogersG. A.: “Alcoholism treated with prochlorperazine.J. Med. Soc. New Jersey56(5): 247–250, May 1959.
76.
RothsteinC., and LacervaS. P.: Prochlorperazine in a psychotic geriatric group.J. Maine Med. Assoc.50(1): 4–7, January 1959.
77.
SainsburyP., and LucasC. J.: Sequential methods applied to the study of prochlorperazine.Brit. Med. J.II (5154): 737–740, October 17, 1959.
78.
SettelE.: Treatment of anxiety and agitation with prochlorperazine in geriatric patients.J. Amer. Geriat. Soc.5(10): 827–831, October 1957.
79.
ShawE. B.: Phenothiazine tranquillizers as a cause of severe seizures.Pediatrics23(3): 485–492, March 1959.
80.
ShubinH., and ShersonJ.: Prochlorperazine in the management of restive aged patients.J. Amer. Geriat. Soc.7(5): 405–407, May 1959.
81.
SmithyG., and HomburgerF.: Prochlorperazine for the treatment of nausea and vomiting in patients with advanced cancer and other chronic diseases.New England J. Med.256(1): 27–28, January 3, 1957.
82.
SolanM. J.: Prochlorperazine and irradiation sickness.Brit. Med. J.II (5159): 1068–1069, January 3, 1959.
83.
SolomonF. A.Jr., and CampagnaF. A.: Jaundice due to prochlorperazine (Compazine).Amer. J. Med.27(5): 840–843, November 1959.
84.
South-East Region (Scotland) Therapeutic Trials Committee.: Controlled trial of prochlorperazine (Stemetil) in schizophrenia.J. Ment. Sc.107 (448): 514–522, May 1961.
85.
StearnsP. E., and SahharF. H.: Prochlorperazine in the treatment of patients with severe mental deficiency.Northwest Med.58(8): 1106–1109, August 1959.
86.
St. LaurentJ.: Treatment of psychiatric patients with a phenothiazine derivative (prochlorperazine) with special reference to after care.Amer. J. Psychiat.118(10): 938–940, April 1962.
87.
SundbyP., and LienJ. B.: Prochlorperazine and chlorpromazine; a comparative clinical trial.Acta Psychiat. Neur. Scand.34(Suppl. 136): 82–88, 1959.
88.
ThimanJ., and GauthierJ. W.: Control of acute alcoholism with prochlorperazine; preliminary report.New England J. Med.260(18): 915–917, April 30, 1959.
89.
VischerT. J.: Clinical study of prochlorperazine, a new tranquillizer for the treatment of nonhospitalized psychoneurotic patients.New England J. Med.256(1): 26–27, January 3, 1957.
90.
WeinsteinA.: Cholestasis due to prochlorperazine.J.A.M.A.170(14): 1663–1664, August 1, 1959.
91.
WilcoxF.: Prochlorperazine in hospitalized and private psychiatric patients.Dis. Nerv. Syst.19(3): 118–121, March 1958.
92.
WilsonI. C.: A double-blind trial to investigate the effects of thorazine (Largactil, chlorpromazine), Compazine (Stemetil, prochlorperazine) and Stelazine (tri-fluoperazine) in paranoid schizophrenia.J. Ment. Sc.107(446): 90–99, January 1961.
93.
WinkelmanN. W.Jr.: Evaluation of two ataractic agents. Experience of one year with prochlorperazine and of seven months with benactyzine.Dis. Nerv. Syst.20(1): 27–30, January 1959.