An Unusual Neurological Side Effect of Psychotropic Drug Treatment *

Bente D. , and Itil T. M. : “Clinico-Electroencephalographic Investigations.” Kline N. , Ed., Psychopharmacology Frontiers, Boston: Little, Brown & Company, 1959, pp. 319–323.

Berry R. V. , Kamin S. H. , and Kline A. : An unusual complication following the use of Trilafon in children. U.S. Armed Forces Med. J. 9: 745–749, 1958.

Cairns H. , Oldfield R. C. , Pennybacker J. B. , and Whitteridge D. : Akinetic mutism with an epidermoid cyst of the third ventricle. Brain 64: 273–291, 1941.

Cravioto H. , Silberman J. , and Feigen I. : A clinical and pathological study of akinetic mutism. Neurology (Minneap.) 10: 10–21, 1960.

DeJong H. H. : Experimental catatonia in animals and induced catatonic stupor in man. Dis. Nerv. Syst. 17: 135–139, 1956.

Denny-Brown D. : Diseases of the basal ganglia. Their relation to disorders of movement. Lancet 11: 1099–1105, 1960.

Evans J. H. : Persistent oral dyskinesia in treatment with phenothiazine derivatives. Lancet 1: 458–460, 1965.

Freeman W. , and Watts J. W. : Retrograde degeneration of the thalamus following prefrontal lobotomy. J. Comp. Neurol. 86: 65–93, 1947.

Gangloff H. , and Monnier M. : Topic action of reserpine, serotonin, and chlorpromazine on the unanesthetized rabbit's brain. Helvet. Physiol. Pharmacol. Acta 15: 83–104, 1957.

Henry C. E. , and Scoville W. B. : Suppression-burst activity from isolated cerebral cortex in man. Electroenceph. Clin. Neurophysiol. 4: 1–22, 1952.

Holden J. M. C. , and Itil T. M. : Rating scale for lobotomized patients. (In press)

Hunter R. , Earl C. J. , and Janz D. : A syndrome of abnormal movements and dementia in leucotomized patients treated with phenothiazines. J. Neurol. Neurosurg. Psychiat. 27: 219–223, 1964.

Itil T. M. : Elektroencephalographische Studien bei Psychosen und psychotropen Medikamenten. Istanbul: Ahmet Sait Matbaasi, 1964.

Itil T. M. , Holden J. M. C. , and Keskiner A. : The problems of organic brain syndrome in the treatment of psychosis. Excerpta Med., Inter. Congr., Series 117, p. 240, 1966.

Itil T. M. , Holden J. M. C. , Keskiner A. , and Fink M. : Altered sensitivity to centrally active drugs following prefrontal lobotomy. Wortis J. , Ed., Recent Advances in Biological Psychiatry. Vol. IX. New York: Plenum Press, 1967, pp. 157–169.

Itil T. M. , Keskiner A. , Kiremitci N. , and Holden J. M. C. : Effect of phencyclidine in chronic schizophrenics. Canad. Psychiat. Ass. J. 12: 209–212, 1967.

Itil T. M. , and Keskiner A. : Psychopathological Rating Scale. Psychiatric Research Foundation of Missouri, Publication No. 12–1966.

Knott J. R. , and Ingram W. R. : EEG in cats with thalamic, hypothalamic and mesencephalic lesions. Electroenceph. Clin. Neurophysiol. 3: 373–374, 1951.

Krueger E. G. , and Wayne H. L. : Clinical and electroencephalographic effects of prefrontal lobotomy and topectomy in chronic psychoses. A. M. A., Arch. Neurol. Psychiat. (Chicago) 67: 661–671, 1952.

Leading Articles: Side effects of phenothiazine drugs. Brit. Med. J. 2: 1412, 1964.

Lennox M. A. , and Coolidge J. : Electroencephalographic changes after prefrontal lobotomy. A.M.A., Arch. Neurol. Psychiat. (Chicago) 62: 150–161, 1949.

Longo V. G. , Von Berger G. P. , and Bovet D. : Action of nicotine and of the ‘ganglio-plegiques centraux’ on the electrical activity of the brain. J. Pharmacol. 111: 349–359, 1954.

May R. H. : Catatonic-like states following phenothiazine therapy. Aimer. J. Psychiat. 115: 1119–1120, 1959.

Morison R. S. , and Dempsey E. W. : A study of thalamo-cortical relations. Amer. J. Physiol. 135: 281–292, 1942.

Morison R. S. , and Bassett D. L. : Electrical activity of the thalamus and basal ganglia in decorticate cats. J. Neurophysiol. 8: 309–314, 1945.

Preston J. B. : Effects of chlorpromazine in the central nervous system of the cat: A possible neural basis for action. J. Pharmacol. Exp. Ther. 118: 100–115, 1956.

Rinaldi F. , and Himwich H. W. : Drugs affecting psychotic behavior and the function of the mesodiencephalic activating system, Dis. Nerv. Syst. 16: 133–141, 1955.

Stern G. : The effects of lesions of the substantia nigra, Brain 89: 449–478, 1966.

Terzian H. : Studio electroencefalografico dell'azione centrale del Largactil (4560 R.P.). Rass. Neurol. Veg. 4–5: 211–215, 1952.