Nine manic patients have been the subjects of a pilot study with a new thioxanthene derivative, thiothixene. Data obtained from two rating scales indicate a significant improvement of the mental and behavioural conditions after three weeks of treatment. Thiothixene like other well-known neuroleptics induces extra-pyramidal symptoms and this tends to confirm the fact that thiothixene is a neuroleptic. The drug was well tolerated; however, we observed a decrease of prothrombin time in four patients.
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