The administration of tri-iodothyronine (T3), 200 mcgs. per day, produced minimal behavioural alteration in a group of 30 chronic schizophrenic patients with known thyroid abnormalities. The combination of 100 mcgs. of T3 and 400 mgs. of chlorpromazine for three months had no beneficial effect on these patients. The above results are discussed in relation to other studies. The presence of purple pigmentation in one of the patients on combined T3 and chlorpromazine is also commented upon.
FlackFrederic F., CelianCharles I. and RawsonRulon W.: Treatment of Psychiatric Disorders With Tri-iodothyronine, Amer. J. Psychiat.,114: 841–842, March 1958.
3.
GreinerA. C., and BerryK.: Skin Pigmentation and Corneal Lens Opacities With Prolonged Chlorpromazine Therapy, Canad. Med. Ass. J.,90/11: 663–665, March 14, 1964.
4.
MeyerBill T. and RubelJ. Lucero: Validation Study of the L-M Fergus Falls Behaviour Rating Scale,J. Clin. Psychology, IX/2: 192–195, April 1953.
5.
PerryThomas L., CullingCharles F. A., BerryKenneth and HansenShirley: 7-Hydroxychlorpromazine: Potential Toxic Drug Metabolite in Psychiatric Patients, Science, 146/3640: 81–82, Oct. 2, 1964.
6.
SimpsonG. M., CranswickE. H. and BlairJ. H.: Thyroid Indices in Chronic Schizophrenia, J. Nerv. and Ment. Dis.,137/6: 582–590, Dec. 1963.
7.
SimpsonG. M., CranswickE. H. and BlairJ. H.: Thyroid Indices in Chronic Schizophrenia: II, 138/6: 581–585, June 1964.
8.
ZelicksonA. S. and ZellerH. C.: Reactions to Chlorpromazine,J. Amer. Med. Ass.,188/4: 394–396, April 27, 1964.
