Three new side effects of prolonged chlorpromazine therapy have been described. Their pathogenesis has been discussed, and increased melanin production was found to be the cause of these manifestations of chlorpromazine melanosis. Skin pigmentation has produced an appearance which is cosmetically undesirable. Ocular deposits have caused visual impairment. Diffuse melanosis of internal organs has been accompanied by functional disturbance of the involved organs. A preliminary report on the therapy of these side effects has been presented.
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