Studies on the use of thioridazine in adults and children were reviewed and the paucity of the controlled objective investigated, observed.
Thioridazine in doses of 25 mg. t.i.d. was administered to nine children with persistent marked aggressivity and hyper-activity. A double-blind study revealed a considerable reduction in aggressive, destructive and hyperactive behaviour. Status epilepticus occurred in an epileptic boy, necessitating an increase in anticonvulsant medication. No other side effects were observed.
It is concluded that thioridazine is a safe and useful drug in the treatment of hyperactive, aggressive, destructive patterns of behaviour in children.
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