Abstract
Two cases are quoted of patients who appear to have taken their lives shortly after changing from chlorpromazine to trifluoperazine. It is suggested that trifluoperazine is less powerful as a tranquilizer, but is a potent anti-psychotic agent which tends to bring the patient back from a non-threatening dream world of chronic hospital adjustment to the distressing aspects of reality. It is suggested that patients should be carefully watched when the change is made to trifluoperazine or else that this drug be given in conjunction with one of the traditional tranquilizers, such as chlorpromazine.
