Abstract

Forty-three institutionalized female patients were treated with a combination of Largactil and anti-epileptic drugs over periods ranging from three to 39 months (mean: 12.8 months). There have been no accidents. As to incidents, there have been a few cases of mild gastro-intestinal intolerance, a number of cases of galactorrhea, and a few extrapyramidal symptoms. Blood tests, which were made regularly, showed a lowering of the BC (from 7000 to 4000), but without any clinical signs.

Treatment was effective in every patient. In chronic conditions, two or three weeks were sometimes sufficient to produce notable improvement of mood; on the other hand, some of the patients began to show a consistently calm mood only after five to seven months. From a total of 43 patients, 12 were markedly improved; 27 were improved and 4 were slightly improved.

It can be concluded that Largactil is undoubtedly effective in the behavioral disturbances of institutionalized epileptics. Moreover, the combination of Largactil with anti-epileptic drugs produces a notable reduction in the incidence of convulsive seizures.