Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis

Abstract

French

Objective:

Children and adolescents are among the most vulnerable road users, and road traffic accidents (RTAs) can lead to not only physical injuries but also adverse psychological outcomes, particularly posttraumatic stress disorder (PTSD). However, estimates of the prevalence of PTSD among children and adolescents following RTAs varied considerably across studies. Therefore, this study aimed to estimate the pooled prevalence of PTSD among this population.

Methods:

A systematic search for literature was performed in the electronic databases of PubMed, Web of Science, PsycINFO, and Embase. Heterogeneity was assessed using the Cochran’s chi-square test and quantified by the I² value. Meta-regression analyses were carried out to identify the effects of some potential moderators on the overall heterogeneity. Subgroup analyses were performed to estimate the pooled prevalence of PTSD according to some sample characteristics.

Results:

Eleven eligible studies with a total of 1532 children and adolescents who were involved in RTAs were included. The overall heterogeneity (I² = 89.7, P < 0.001) was high across the eligible studies, and the pooled prevalence of PTSD was 19.95% (95% confidence interval, 13.63% to 27.09%) by a random-effects model. No significant moderators of the overall heterogeneity were identified using meta-regression analyses. Subgroup analyses showed that the pooled prevalence of PTSD differed significantly according to the study location and gender (P < 0.05).

Conclusions:

One-fifth of children and adolescents developed PTSD in the aftermath of RTAs, indicating the need for regular assessment of PTSD and timely and effective psychological interventions among this population. Furthermore, more population-based studies with a large sample size are warranted. The protocol was registered in the PROSPERO database (No. CRD42018087941).

Keywords

posttraumatic stress disorder road traffic accident child adolescent prevalence meta-analysis

The size of the population involved in road traffic accidents (RTAs) has grown worldwide over the past few decades.^1,2 According to the statistics by the World Health Organization (WHO), globally, 1.2 million people are killed in RTAs each year, and as many as 50 million are injured or disabled.³ Among all types of road users, children and adolescents are considered the most vulnerable.^1,4 In 2004, road traffic injuries accounted for almost 262,000 deaths among children and adolescents aged 0 to 19 years, and among those aged 15 to 19 years and 5 to 14 years, road traffic injuries are the first and second leading cause of death, respectively.⁵ In addition to causing deaths and injuries, RTAs can lead to adverse psychological outcomes, particularly posttraumatic stress disorder (PTSD).^6,7

PTSD could develop after exposure to an unintentional traumatic event, and RTA is the most common unintentional traumatic event that may involve children and adolescents.^8,9 According to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), PTSD is characterized by 4 symptom clusters, including marked intrusion, avoidance, negative alterations in cognitions and mood, and marked alterations in arousal and reactivity symptoms, and these full symptom clusters must last at least 1 month.¹⁰ Studies on effects of various kinds of traumatic events have consistently shown that childhood PTSD could have long-term adverse effects on the quality of life. For example, Zatzick et al.¹¹ interviewed 108 adolescents who experienced physical injuries and found that early PTSD symptoms were associated with a wide range of functional impairment at 1-year follow-up after the physical injury, and in a population-based survey of 596 children by Jia et al.,¹² it was found that PTSD was strongly negatively associated with health-related quality of life 15 months after the 2008 Sichuan earthquake. Furthermore, Landolt et al.¹³ conducted a prospective study among 68 children following RTAs and found that early PTSD symptoms could have long-term adverse effects on health-related quality of life.

There has been a growing research interest in PTSD among children and adolescents following RTAs in recent years, with the estimates of the prevalence of PTSD varying considerably from 4.9% to 34.5% across the individual studies.^4,14
–16 This variation could be accounted for by some factors such as the differences in the interval between the occurrence of a trauma and assessment of PTSD (trauma assessment interval), tool used to assess PTSD, and sample characteristics, including gender, type of RTA, and injury severity.^15

–18 In addition, differences in social support, family cohesion, and parenting behaviors may contribute to the variation in the prevalence of PTSD among children and adolescents.^19
–21 A valid estimate of the pooled prevalence of PTSD among children and adolescents following RTAs is needed, since it could not only facilitate the efforts of the mental health providers to identify the accurate number of children and adolescents who may develop PTSD but also help balance the cost of prevention and treatment of PTSD by allocating psychological intervention resources proportionally. However, systematic research on PTSD among children and adolescents following RTAs is limited, and to date, no study has reported the pooled prevalence of PTSD among this population. Therefore, this study aimed to identify the pooled prevalence of PTSD among children and adolescents following RTAs by synthesizing relevant evidence through meta-analysis.

Methods

Search Strategy

This meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (see Suppl. File S1). The protocol was registered in the PROSPERO database (No. CRD42018087941).

A systematic search for literature was performed in the electronic databases of PubMed, Web of Science, PsycINFO, and Embase up to January 2018. A combination of the subject headings related to PTSD, RTA, and children or adolescents was used as the search terms. For example, the search terms for the database of PubMed were as follows: ((“Stress Disorders, Post-Traumatic”[Mesh]) AND (“Child”[Mesh] OR “Adolescent”[Mesh])) AND “Accidents, Traffic”[Mesh]). A full list of the search terms is in Supplemental File S2. Furthermore, all reference lists of the included studies were manually searched for further relevant publications.

Eligibility Criteria

Two reviewers (W.D. and A.C.K.) independently identified the eligibility of studies. The inclusion criteria were 1) observational studies investigating PTSD among children and adolescents who were involved in an RTA, regardless of type of RTA; 2) PTSD was assessed at least 1 month after the RTA using the self-report questionnaires or structured interviews according to the DSM criteria; 3) data on the sample size and the prevalence of PTSD among children and adolescents following an RTA were reported; and (4) full article was written in English. In addition, for longitudinal studies, only the prevalence of PTSD at baseline was included, and if duplicated data were observed, only the first publication was included. Studies were excluded if they were abstracts, case reports, comments, reviews, dissertations, or book chapters. Any discrepancies between the 2 reviewers were resolved via consensus.

Data Extraction

Two reviewers (W.D. and A.C.K.) independently extracted the following data and assessed the risk of bias from each eligible study: first author, year of publication, study location, study design, sample source, age, male proportion, trauma assessment interval, tool used to assess PTSD, number of subjects with PTSD, sample size, and the prevalence of PTSD. Furthermore, if available, data regarding the type of RTA and parental reporting of children’s PTSD were extracted to perform subgroup analyses. Any disagreements between the foregoing reviewers were resolved via discussion with a third reviewer (J.D.), and an unweighted κ value was calculated to evaluate the agreement between reviewers.

Risk-of-Bias Assessment

The Loney criteria were used to assess the risk of bias for each eligible study. This scale is widely used to assess the quality of observational studies on the prevalence of health-related outcomes.^22
–24 It consists of 8 items to comprehensively evaluate the risk of bias such as unbiased sampling frame, adequate sample size, and standard tools. A study is given 1 point for each item it meets, making the maximal total score to be 8 points, with higher scores suggesting lower risk of bias.

Statistical Analysis

All statistical analyses were conducted in R statistical software version 3.4.1 (https://www.r-project.org) using the “meta” and “metafor” packages.

Estimates of the prevalence of PTSD among eligible studies were transformed using the Freeman-Tukey double arcsine method. Heterogeneity was assessed using Cochran’s χ² test and quantified by the I² value, which indicates the percentage of the total variation due to interstudy heterogeneity rather than chance. An I² value of <25%, 25% to 75%, and >75% suggests low, moderate, and high degree of heterogeneity, respectively.²⁵ The pooled prevalence of PTSD was synthesized by a random-effects model if significant heterogeneity (P value for Cochran’s χ² test <0.05) was observed across studies. In contrast, a fixed-effects model was applied.^26,27 For each pooled estimate, its corresponding 95% confidence interval (CI) was calculated.

Meta-regression analyses with a mixed-effect model were carried out to identify the effects of potential moderators on the overall heterogeneity using the restricted maximum-likelihood estimator method if significant heterogeneity was observed across all included studies. Potential moderators included the study design, mean age, male proportion, tool used to assess PTSD, and score of risk-of-bias assessment.

Subgroup analyses were performed to estimate the pooled prevalence of PTSD with regard to study location, trauma assessment interval, tool used to assess PTSD, gender, type of RTA, and parental reporting of children’s PTSD. The χ² test was used to assess the differences across each subgroup, and the significance level was set at P < 0.05.

Sensitivity analysis was performed by serially removing studies one by one to show the effect of that on the effect sizes.²⁸ Publication bias was evaluated not only visually by presenting a funnel plot for asymmetry but also statistically by performing Begg’s rank test and Egger’s linear test. Furthermore, the trim-and-fill method was used to obtain an adjusted pooled estimate in the presence of publication bias.²⁹

Results

Search Results

Figure 1 shows the PRISMA flowchart of the selection process of the eligible studies. A total of 622 records were initially retrieved from the databases by the search strategy. After removal of duplicated records, 388 records were screened. After abstract screening, 41 full-text articles were shortlisted for potential eligibility. Among these 41 articles, 4 were excluded for not identifying PTSD at least 1 month after the RTA, 2 were excluded for not identifying PTSD according to the DSM criteria, 16 were excluded for not reporting the prevalence of PTSD among children and adolescents following the RTA, and 8 were excluded for duplicated data (Suppl. File S3). Therefore, 11 eligible articles were ultimately included in this study.

Figure 1.

Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart of the study selection process of the eligible studies. PTSD, posttraumatic stress disorder; RTA, road traffic accident.

Study Characteristics

Table 1 shows the characteristics of the eligible studies. The 11 eligible studies were carried out in 5 countries, including the United States, United Kingdom, Greece, France, and China. In addition, 7 were longitudinal and 4 were cross-sectional; 10 recruited participants from hospital and 1 recruited participants via the official police accident reports; 2 made the diagnosis of PTSD using exclusively self-report questionnaire, 8 using exclusively structured interview, and 1 using both the structured interview and the self-report questionnaire. The trauma assessment interval of these studies ranged from 1 month to 18 months following the RTA, and the mean age of participants ranged from 6.5 to 13.97 years.

Table 1.

Characteristics of the Eligible Studies Included in This Meta-Analysis.

First Author	Year of Publication	Study Location	Study Design	Sample Source	Age, y		Male Proportion, %	Trauma Assessment Interval	Tool Used to Assess PTSD		No. of Subjects with PTSD	Sample Size	PTSD Prevalence, %
First Author	Year of Publication	Study Location	Study Design	Sample Source	Range	Mean (SD)	Male Proportion, %	Trauma Assessment Interval	Self-report questionnaire	Structured interview	No. of Subjects with PTSD	Sample Size	PTSD Prevalence, %
Mirza³⁰	1998	United Kingdom	Longitudinal	Hospital based	8-16	13.61 (2.44)	68.1	9-13 weeks	FRI	K-SADS-L (DSM-IV)	33	119	27.7
Stallard¹⁶	1998	United Kingdom	Cross-sectional	Hospital based	5-18	13.97 (3.59)	57.1	40.3 days	—	CAPS-C (DSM-IV)	41	119	34.5
de Vries¹⁷	1999	United States	Cross-sectional	Hospital based	3-17	9.4 (3.5)	66.7	7-12 months	PCL-C (DSM-IV)	—	26	102	25.5
Keppel-Benson³¹	2002	United States	Cross-sectional	Official police accident reports	7-16	11.6 (3.2)	58.0	2-18 months	—	DICA-R (DSM-III-R)	7	50	14.0
Zink³²	2003	United States	Longitudinal	Hospital based	7-15	10.8 (2.6)	59.4	2 months	—	DICA-R (DSM-III)	26	143	18.2
Kassam-Adams³³	2004	United States	Longitudinal	Hospital based	8-17	11.3 (2.5)	74.9	3-12 months	—	CAPS-CA (DSM-IV)	10	177	5.6
Bryant³⁴	2004	United Kingdom	Longitudinal	Hospital based	5-16	12.27 (2.86)	55.0	3 months	Questions based on DSM-IV criteria	—	19	81	23.5
Pervanidou³⁵	2007	Greece	Longitudinal	Hospital based	7-18	10.96 (2.51)	71.4	1 month	—	K-SADS-L (DSM-IV)	23	56	41.1
Bui¹⁵	2010	France	Cross-sectional	Hospital based	8-15	11.7 (2.2)	53.4	5 weeks	—	CAPS-CA (DSM-IV)	5	103	4.9
Wu¹⁸	2016	China	Longitudinal	Hospital based	1-13	6.8 (0.9)	53.8	3 months	—	CAPS-CA (DSM-IV)	133	537	24.8
Meiser-Stedman⁶	2017	United Kingdom	Longitudinal	Hospital based	2-10	6.5 (2.8)	52.1	6 months	—	CAPS-CA (DSM-IV)	6	45	13.3

CAPS-C, Clinician-Administered PTSD Scale for Children; CAPS-CA, Clinician-Administered PTSD Scale for Children and Adolescents; DSM, Diagnostic and Statistical Manual of Mental Disorders; DICA-R, Diagnostic Interview for Children and Adolescents–Revised Version; FRI, Frederick’s Reaction Index; K-SADS-L, Kiddie-Schedule for Affective Disorders and Schizophrenia-Lifetime Version; PCL-C, PTSD checklist for children; PTSD, post-traumatic stress disorder; SD, standard deviation.

Risk-of-Bias Assessment

The results of risk-of-bias assessment are shown in Supplemental File S4. Based on the Loney criteria, 7 of the 11 eligible studies were scored 5 points, 3 scored 4 points, and 1 scored 6 points. None of them used a random sampling method or recruited participants from the whole population. Furthermore, none applied unbiased sampling frame, and only 1 had an adequate sample size of >300. Agreement between the 2 reviewers assessing the risk of bias using the Loney criteria was good (κ = 0.69).

Pooled Prevalence of PTSD among Children and Adolescents following RTA

Figure 2 shows the forest plot of all included studies. A total of 1532 children and adolescents were screened in the aftermath of RTAs, of which 329 were identified with PTSD. Estimates of the prevalence of PTSD across the 11 eligible studies ranged from 4.9% to 41.1%. The lowest prevalence of PTSD (4.9%) was reported in France in a hospital-based study conducted 5 weeks after the RTA,¹⁵ and the highest prevalence of PTSD (41.1%) was reported in Greece in a hospital-based study conducted 1 month after the RTA.³⁵ Significantly high heterogeneity (I² = 89.7, P < 0.001) was observed across all included studies, and the pooled prevalence of PTSD among children and adolescents following the RTA was 19.95% (95% CI, 13.63% to 27.09%) using a random-effects model.

Figure 2.

Forest plot of the 11 eligible studies.

Meta-Regression Analyses

The results of meta-regression analyses indicated that the study design (P = 0.761), male proportion (P = 0.724), mean age of participants (P = 0.684), tool used to assess PTSD (P = 0.581), and score of risk-of-bias assessment (P = 0.244) were not significant moderators of the overall heterogeneity. Detailed data are shown in Supplemental File S5.

Subgroup Analyses

Table 2 shows the results of subgroup analyses. For studies conducted <3 months and ≥3 months following the RTA, the pooled prevalence of PTSD was 23.49% (95% CI, 11.96% to 37.41%) and 17.76% (95% CI, 9.23% to 28.25%), respectively. For studies using exclusively self-report questionnaire and exclusively structured interview to assess PTSD, the pooled prevalence of PTSD was 24.58% (95% CI, 18.55% to 31.14%) and 17.96% (95% CI, 10.19% to 27.28%), respectively. For the studies conducted in the United States and United Kingdom, the pooled prevalence of PTSD was 14.93% (95% CI, 6.57% to 25.80%) and 25.46% (95% CI, 18.04% to 33.64%), respectively. In addition, for male and female subjects, the pooled prevalence of PTSD was 22.21% (95% CI, 18.66% to 25.96%) and 34.45% (95% CI, 21.94% to 48.12%), respectively. Furthermore, the pooled prevalence of PTSD among subjects who reported PTSD by themselves was 20.32% (95% CI, 12.07% to 30.01%), and for those whose symptoms were reported by their parents, the pooled prevalence was 19.76% (95% CI, 15.30% to 24.61%).

Table 2.

Subgroup Analyses of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents.

Subgroup/Category	No. of Studies	No. of Subjects with PTSD	Sample Size	Pooled Prevalence (95% CI), %	χ² Value	P Value
Trauma assessment interval					1.951	0.162
<3 months	5	128	540	23.49 (11.96 to 37.41)
≥3 months	5	194	942	17.76 (9.23 to 28.25)
Tool used to assess PTSD					1.684	0.194
Self-report questionnaire	2	45	183	24.58 (18.55 to 31.14)^a
Structured interview	8	251	1230	17.96 (10.19 to 27.28)
Study location					20.252	<0.001^b
United States	4	69	472	14.93 (6.57 to 25.80)
United Kingdom	4	99	364	25.46 (18.04 to 33.64)
Gender					7.090	0.008^b
Male	4	114	510	22.21 (18.66 to 25.96)^a
Female	4	118	391	34.45 (21.94 to 48.12)
Type of RTA					4.673	0.097
Auto occupant	3	40	130	30.37 (22.53 to 38.79)^a
Pedestrian	3	36	118	30.43 (22.29 to 39.21)^a
Bicyclist	3	23	116	19.65 (12.70 to 27.60)
Parental reporting of children’s PTSD					0.462	0.497
Yes	3	58	290	19.76 (15.30 to 24.61)^a
No	8	271	1242	20.32 (12.07 to 30.01)

CI, confidence interval; PTSD, posttraumatic stress disorder; RTA, road traffic accident.

^a Data were combined using a fixed-effects model.

^bP value for χ² tests <0.05.

The results of χ² tests indicated that the pooled prevalence of PTSD among children and adolescents following RTAs differed significantly according to the study location and gender (P < 0.05). Specifically, the pooled prevalence of PTSD among subjects in the United States was significantly lower than that among subjects in the United Kingdom (P < 0.05), and the pooled prevalence of PTSD among female subjects was significantly higher than that among male subjects (P < 0.05). In addition, the pooled prevalence of PTSD among subjects did not differ significantly according to the trauma assessment interval, tool used to assess PTSD, type of RTA, and parental reporting of children’s PTSD (P > 0.05).

Sensitivity Analysis and Publication Bias

After serially removing studies one by one, the I² values ranged from 83.9% to 90.7%, and the pooled prevalence of PTSD ranged from 18.30% (95% CI, 12.18% to 25.31%) to 21.95% (95% CI, 16.18% to 28.30%), indicating low sensitivity.

Figure 3 shows the funnel plot of all included studies. The funnel plot was almost symmetrical, and both the results of Begg’s rank test (z = –0.468, P = 0.639) and Egger’s linear test (t = –0.274, P = 0.790) indicated no significant publication bias.

Figure 3.

Funnel plot of the 11 eligible studies.

Discussion

To our knowledge, this is the first meta-analysis to estimate the pooled prevalence of PTSD among children and adolescents following an RTA. This study included 11 eligible studies with a total of 1532 children and adolescents who were involved in RTAs. The results indicated that one-fifth of these children and adolescents developed PTSD in the aftermath of RTAs, and in comparison with results of similar meta-analyses exploring the pooled prevalence of PTSD following specific traumatic events, the pooled prevalence of PTSD found in this study (19.95%) was lower than that among earthquake survivors (23.66%),²³ adult RTA survivors (22.25%),³⁶ adult patients after acute orthopaedic trauma (26.6%),³⁷ and children exposed to a war (47%).³⁸ However, it was much higher than that among flood survivors (15.74%),³⁹ patients of stroke and transient ischemic attack (13%),⁴⁰ patients with chronic pain (9.7%),⁴¹ and patients with breast cancer (9.6%).⁴² The high pooled prevalence of PTSD among children and adolescents following RTAs suggests that, in addition to the physical treatment, the service providers should pay special attention to the mental health of this population, and routine assessment of PTSD is imperative. Furthermore, given the fact that childhood PTSD may lead to long-term adverse effects on the quality of life, timely and effective psychological interventions such as cognitive behavior therapy are needed for children and adolescents following RTAs.⁴³

Numerous studies have consistently shown that the prevalence of PTSD was associated with the timing of PTSD assessment following specific traumatic events. For example, Edmondson et al.⁴⁰ conducted a meta-analysis exploring the pooled prevalence of PTSD among survivors of stroke and transient ischemic attack and found that the pooled prevalence of PTSD assessed within 1 year following stroke and transient ischemic attack (23%) was significantly higher than that assessed at more than 1 year (11%). In addition, Hiller et al.⁴⁴ conducted a meta-analysis of longitudinal studies on PTSD among those aged 5 to 18 years and found moderate declines in the prevalence of PTSD as well as the symptom severity of PTSD over the first 3 to 6 months posttrauma. This variation could be explained by the possibility of recovery from PTSD over time.^45,46 For example, Truss et al.⁴⁶ found that the prevalence of clinically posttraumatic symptoms among 122 children following pediatric concussion was 16%, 10%, and 6% at 2 weeks, 1 month, and 3 months postconcussion, respectively, and 25% of the children recovered from PTSD during the 3 months. However, in this study, although the results of subgroup analyses indicated that the pooled prevalence of PTSD assessed at less than 3 months after RTAs (23.49%) was higher than that assessed at least 3 months after RTAs (17.76%), this variation was not significant. Possible reasons could be that the number of relevant studies was limited when synthesizing the data and the heterogeneity across relevant studies was high.

It has been widely understood that the self-report questionnaires are more likely to overestimate the prevalence of PTSD than the structured interviews. For example, Siqveland et al.⁴¹ synthesized the results of 21 studies exploring the prevalence of PTSD among patients with chronic pain and found that the prevalence of PTSD identified by self-reported questionnaire (20.4%) was significantly higher than that identified by structured interview (4.5%). Similar result was observed in a study exploring the pooled prevalence of PTSD among cancer patients.⁴⁷ However, no significant difference in the pooled prevalence of PTSD according to the tool used to assess PTSD was observed in this study. It is worth noting here that only 2 eligible studies used self-report questionnaires to assess PTSD when synthesizing relevant data, which may explain the inconsistency of the preceding results with those of previous similar studies.

Furthermore, the pooled prevalence of PTSD in this study differed significantly according to the study location and gender. Country difference in PTSD prevalence could be attributed to the differences in sample characteristics, including socioeconomic, sociocultural, and biological characteristics.^48,49 In addition, gender difference in the pooled prevalence of PTSD could be accounted for by the gender differences in the interpretation of stressful events and the strategies used to cope with stressful events.^50,51 These findings indicate that the service providers should allocate the psychological intervention resources to those who were involved in RTAs proportionally according to the degree of the prevalence of PTSD in a country, and special attention should be paid to girls.

Few studies have compared the parent-child discrepancy in reporting children’s PTSD symptoms. In a study by Dyb et al.,⁵² it was found that parents reported significantly less children’s PTSD symptoms than children themselves, and this parent-child discrepancy was more prominent among much younger children. The results of our study showed that the pooled prevalence of children’s PTSD reported by children and adolescents did not differ significantly from that reported by their parents. Given the limited number of studies that provided relevant data, future studies are still needed to clarify this discrepancy.

In terms of risk-of-bias assessment, it is worth noting here that none of the 11 eligible studies were population based, and almost all eligible studies recruited participants from hospital, which may not only induce selection bias but also preclude from generalizing our findings to population-based studies. Also, only 1 of the eligible studies had a sample size of >300. Studies with a small sample size may tend to overestimate the effect size.⁵³ In this regard, more population-based studies with a large sample size are warranted. In addition, many previous studies have consistently shown that risk of bias was an important source of the heterogeneity.^54,55 However, the results of meta-regression analyses in this study showed that risk-of-bias assessment score was not a significant moderator of the overall heterogeneity. This may be due to the fact that, although the risk-of-bias assessment score differed from 4 to 6 points across the eligible studies, these studies were mostly at moderate risk of bias.

Some limitations should be acknowledged. First, subgroup analysis according to the injury severity was unable to be performed since the instruments used to assess injury severity were quite inconsistent across the eligible studies. Among the eligible studies, de Vries et al.¹⁷ found that injury severity was not related to PTSD, while Keppel-Benson et al.³¹ found that severe physical injury predicted more PTSD symptoms. Therefore, more future studies using consistently standard scales such as an injury severity scale to assess injury severity are needed. Second, none of the 11 eligible studies assessed PTSD based on the DSM-5 criteria, which may preclude from generalizing our findings to the studies using the tools according to the DSM-5 criteria to identify PTSD. Third, the differences in the pooled prevalence of PTSD within each subgroup were compared in the absence of adjustment for potential confounders. In addition, the overall heterogeneity was high across the eligible studies, and no significant moderators of the overall heterogeneity were identified in this study, indicating that future studies should explore more factors that may contribute to the differences in the prevalence of PTSD among children and adolescents following RTAs, such as history of psychiatric disorders, history of previous traumatic events, social support, and parenting behaviors.

Conclusions

The pooled prevalence of PTSD among children and adolescents following RTAs was 19.95% (95% CI, 13.63% to 27.09%), which underscores the importance of regular assessment of PTSD among this population, as well as the need for the implementation of timely and effective psychological interventions. No significant moderators of the overall heterogeneity were identified in this study, indicating that future studies should explore more factors associated with PTSD among children and adolescents who have been involved in RTAs. Furthermore, more population-based studies with a large sample size as well as an unbiased sampling frame are needed.

Supplemental Material

Supplemental_file_1 - Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis

Supplemental_file_1 for Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis by Wenjie Dai, Aizhong Liu, Atipatsa C. Kaminga, Jing Deng, Zhiwei Lai, and Shi Wu Wen in The Canadian Journal of Psychiatry

Supplemental Material

Supplemental_file_2 - Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis

Supplemental_file_2 for Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis by Wenjie Dai, Aizhong Liu, Atipatsa C. Kaminga, Jing Deng, Zhiwei Lai, and Shi Wu Wen in The Canadian Journal of Psychiatry

Supplemental Material

Supplemental_file_3 - Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis

Supplemental_file_3 for Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis by Wenjie Dai, Aizhong Liu, Atipatsa C. Kaminga, Jing Deng, Zhiwei Lai, and Shi Wu Wen in The Canadian Journal of Psychiatry

Supplemental Material

Supplemental_file_4 - Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis

Supplemental_file_4 for Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis by Wenjie Dai, Aizhong Liu, Atipatsa C. Kaminga, Jing Deng, Zhiwei Lai, and Shi Wu Wen in The Canadian Journal of Psychiatry

Supplemental Material

Supplemental_file_5 - Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis

Supplemental_file_5 for Prevalence of Posttraumatic Stress Disorder among Children and Adolescents following Road Traffic Accidents: A Meta-Analysis by Wenjie Dai, Aizhong Liu, Atipatsa C. Kaminga, Jing Deng, Zhiwei Lai, and Shi Wu Wen in The Canadian Journal of Psychiatry

Footnotes

Acknowledgments

We are grateful to all authors of the full-text articles.

Author Contribution

Aizhong Liu and Shi Wu Wen contributed to the concept and design of this study. Wenjie Dai, Atipatsa C. Kaminga, and Jing Deng contributed to the data acquisition, analysis, and interpretation. Wenjie Dai drafted the manuscript. Atipatsa C. Kaminga and Zhiwei Lai critically revised the manuscript for important intellectual content. All authors approved the final version of publication.

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported in part by the Canadian Institutes of Health Research Foundation (FDN-148438); the Specialized Research Fund for the Doctoral Program of Higher Education (20130162110054); the Natural Science Foundation of Hunan Province, China (2016JJ2153); and the Fundamental Research Funds for the postgraduates of Central South University (2015zzts282).

ORCID iD

Wenjie Dai, MD

Supplemental Material

Supplemental material for this article is available online.

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