The STAR*D Trial: It is Time to Reexamine the Clinical Beliefs That Guide the Treatment of Major Depression

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Fava M Rush AJ Trivedi MH Background and rationale for the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Psychiatr Clin North Am. 2003;26:457–494.

Rush AJ Trivedi MH Wisniewski SR Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. N Engl J Med. 2006;354:1231–1242.

Trivedi MH Fava M Wisniewski SR Medication augmentation after the failure of SSRIs for depression. N Engl J Med. 2006;354:1243–1252.

Rush AJ Trivedi MH Wisniewski SR Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report. Am J Psychiatry. 2006;163:1905–1917.

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National Institute of Mental Health (NIMH). Sequenced Treatment Alternatives to Relieve Depression (STAR*D) research protocol. Revised ed. Washington (DC): NIMH; 2002. Received October 1, 2010, from NIMH following a request under the Freedom of Information Act. Also available from: http://www.madinamerica.com/wp-content/uploads/2011/12/STAR-D%20Protocol%20with%20Analytic%20Plan.pdf.

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Barbui C Furukawa TA Cipriani A. Effectiveness of paroxetine in the treatment of acute major depression in adults: A systematic re-examination of published and unpublished data from randomized trials. CMAJ. 2008;178:296–305.

Fava M Rush AJ Wisniewski SR A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: A STAR*D report. Am J Psychiatry. 2006;163:1161–1172.

Nierenberg AA Fava M Trivedi MH A comparison of lithium and T3 augmentation following two failed medication treatments for depression: A STAR*D report. Am J Psychiatry. 2006;163:1519–1530.

McGrath PJ Stewart JW Fava M Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medications trials for depression: A STAR*D report. Am J Psychiatry. 2006;163:1531–1541.

Trivedi MH Morris DW Wisniewski SR Increase in work productivity of depressed individuals with improvement in depressive symptom severity. Am J Psychiatry. 2013;170:633–641.

Gaynes BN Rush AJ Trivedi MH The STAR*D study: Treating depression in the real world. Clev Clin J Med. 2008;75:57–66.

Morris DW Trivedi MH . Measurement-based care for unipolar depression. Curr Psychiatry Rep. 2011;13(6):446–458.

Shelton RC Trivedi MH . Using algorithms and computerized decision support systems to treat major depression. J Clin Psychiatry. 2011;72(12):e36.

Trivedi MH . Evaluating and monitoring treatment response in depression using measurement-based assessment and rating scales. J Clin Psychiatry. 2013;74(7):e14.

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