Cognitive Dysfunction in Major Depressive Disorder: Effects on Psychosocial Functioning and Implications for Treatment

Gilmour H Patten SB . Depression and work impairment. Health Rep. 2007;18:9–22.

Ferrari AJ Charlson FJ Norman RE Burden of depressive disorders by country, sex, age, and year: Findings from the global burden of disease study 2010. PLoS Med. 2013;10:e1001547.

Lam RW Filteau MJ Milev R. Clinical effectiveness: The importance of psychosocial functioning outcomes. J Affect Disord. 2011;132(Suppl 1):S9–S13.

Greer TL Kurian BT Trivedi MH . Defining and measuring functional recovery from depression. CNS Drugs. 2010;24:267–284.

Zimmerman M McGlinchey JB Posternak MA Discordance between self-reported symptom severity and psychosocial functioning ratings in depressed outpatients: Implications for how remission from depression should be defined. Psychiatry Res. 2006;141:185–191.

McIntyre RS Cha DS Soczynska JK Cognitive deficits and functional outcomes in major depressive disorder: Determinants, substrates, and treatment interventions. Depress Anxiety. 2013;30:515–527.

Murrough JW Iacoviello B Neumeister A Cognitive dysfunction in depression: Neurocircuitry and new therapeutic strategies. Neurobiol Learn Mem. 2011;96:553–563.

Hasselbalch BJ Knorr U Hasselbalch SG Cognitive deficits in the remitted state of unipolar depressive disorder. Neuropsychology. 2012;26:642–651.

Chamberlain SR Sahakian BJ . The neuropsychology of mood disorders. Curr Psychiatry Rep. 2006;8:458–463.

Conradi HJ Ormel J de Jonge P. Presence of individual (residual) symptoms during depressive episodes and periods of remission: A 3-year prospective study. Psychol Med. 2011;41:1165–1174.

Baune BT Miller R McAfoose J The role of cognitive impairment in general functioning in major depression. Psychiatry Res. 2010;176:183–189.

Halvorsen M Hoifodt RS Myrbakk IN Cognitive function in unipolar major depression: A comparison of currently depressed, previously depressed, and never depressed individuals. J Clin Exp Neuropsychol. 2012;34:782–790.

Snyder HR . Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: A meta-analysis and review. Psychol Bull. 2013;130:81–132.

Hasselbalch BJ Knorr U Kessing LV . Cognitive impairment in the remitted state of unipolar depressive disorder: A systematic review. J Affect Disord. 2011;134:20–31.

Disner SG Beevers CG Haigh EA Neural mechanisms of the cognitive model of depression. Nat Rev Neurosci. 2011;12:467–477.

Withall A Harris LM Cumming SR . A longitudinal study of cognitive function in melancholic and non-melancholic subtypes of major depressive disorder. J Affect Disord. 2010;123:150–157.

Jaeger J Berns S Uzelac S Neurocognitive deficits and disability in major depressive disorder. Psychiatry Res. 2006;145:39–48.

Naismith SL Longley WA Scott EM Disability in major depression related to self-rated and objectively-measured cognitive deficits: A preliminary study. BMC Psychiatry. 2007;7:32–38.

Antikainen R Hänninen T Honkalampi K Mood improvement reduces memory complaints in depressed patients. Eur Arch Psychiatry Clin Neurosci. 2001;251:6–11.

Hasselbalch BJ Knorr U Hasselbalch SG The cumulative load of depressive illness is associated with cognitive function in the remitted state of unipolar depressive disorder. Eur Psychiatry. 2013;28:349–355.

Evans VC Chan SS Iverson GL Systematic review of neurocognition and occupational functioning in major depressive disorder. Neuropsychiatry. 2013;3:97–105.

Evans VC Iverson GL Yatham LN The relationship between neurocognitive and psychosocial functioning in major depressive disorder: A systematic review. J Clin Psychiatry. Forthcoming.

Buist-Bouwman MA Ormel J de Graaf R Mediators of the association between depression and role functioning. Acta Psychiatr Scand. 2008;188:451–458.

Herrera-Guzman I Gudayol-Ferré E Herrera-Guzman D Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on memory and mental processing speed in patients with major depressive disorder. J Psychiatry Res. 2009;43:855–863.

Fava M Graves LM Benazzi F A cross-sectional study of the prevalence of cognitive and physical symptoms during long-term treatment. J Clin Psychiatry. 2006;67:1754–1759.

Nuechterline KH Green MF Kern RS The MATRICS Consensus Cognitive Battery, part 1: Test selection, reliability, and validity. Am J Psychiatry. 2008;165:203–213.

Yatham LN Torres IJ Malhi GS The International Society for Bipolar Disorders—Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disord. 2010;12:351–363.

Walker MP . Cognitive consequences of sleep and sleep loss. Sleep Med. 2008;9(Suppl 1):S29–S34.

Durmer JS Dinges DF . Neurocognitive consequences of sleep deprivation. Semin Neurol. 2005;25:117–129.

Wagner S Doering B Helmreich I A meta-analysis of executive dysfunctions in unipolar major depressive disorder without psychotic symptoms and their changes during antidepressant treatment. Acta Psychiatr Scand. 2012;125:281–292.

McLennan SN Mathias JL . The depression-executive dysfunction (DED) syndrome and response to antidepressants: A meta-analytic review. Int J Geriatr Psychiatry. 2010;25:933–944.

Herrera-Guzman I Gudayol-Ferré E Lira-Mandujano J Cognitive predictors of treatment response to bupropion and cognitive effects of bupropion in patients with major depressive disorder. Psychiatry Res. 2008;160:72–82.

Herrera-Guzman I Gudayol-Ferré E Herrera-Abarca JE Major depressive disorder in recovery and neuropsychological functioning: Effects of selective serotonin reuptake inhibitor and dual inhibitor depression treatments on residual cognitive deficits in patients with major depressive disorder in recovery. J Affect Disord. 2010;123:341–350.

Ferguson JM Wesnes KA Schwartz GE . Reboxetine versus paroxetine versus placebo: Effects on cognitive functioning in depressed patients. Int Clin Psychopharmacol. 2003;18:9–14.

Raskin J Wiltse CG Siegal A Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: An 8-week, double-blind, placebo-controlled trial. Am J Psychiatry. 2007;164:900–909.

Constant EL Adam S Gillain B Effects of sertraline on depressive symptoms and attentional and executive functions in major depression. Depress Anxiety. 2005;21:78–89.

Gualtieri CT Johnson LG . Bupropion normalizes cognitive performance in patients with depression. MedGenMed. 2007;9:22.

Culang-Reinlieb ME Sneed JR Keilp JG Change in cognitive functioning in depressed older adults following treatment with sertraline or nortriptyline. Int J Geriatr Psychiatry. 2012;27:777–784.

Katona C Hansen T Olsen CK . A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of LU AA21004 in elderly patients with major depressive disorder. Int Clin Psychopharmacol. 2012;27:215–223.

McIntyre RS Lophaven S Olsen CK . A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive dysfunction in depressed adults. Int J Neuropsychopharmacol. 2014;17:1557–1567.

Dunn TW Vittengl JR Clark LA Change in psychosocial functioning and depressive symptoms during acute-phase cognitive therapy for depression. Psychol Med. 2011;25:1–10.

Conradi HJ de Jonge P Ormel J. Cognitive-behavioural therapy v usual care in recurrent depression. Br J Psychiatry. 2008;193:505–506.

Wykes T Reeder C Landau S Does age matter? Effects of cognitive rehabilitation across the age span. Schizophrenia Res. 2009;113:252–258.

Deckersbach T Nierenberg AA Kessler R Cognitive rehabilitation for bipolar disorder: An open trial for employed patients with residual depressive symptoms. CNS Neurosci Ther. 2010;16:298–307.

Bowie CR Gupta M Holshausen K. Cognitive remediation therapy for mood disorders: Rationale, early evidence, and future directions. Can J Psychiatry. 2013;58:319–325.

Raes F Williams JM Hermans D. Reducing cognitive vulnerability to depression: A preliminary investigation of MEmory Specificity Training (MEST) in inpatients with depressive symptomatology. J Behav Ther Exp Psychiatry. 2009;40:24–38.

Meyers BS Mattis S Gabriele M Effects of nortriptyline on memory self-assessment and performance in recovered elderly depressives. Psychopharmacol Bull. 1991;27:295–299.

Biringer E Arvid R Anders L. A review of modern antidepressants' effects on neurocognitive function. Curr Psychiatry Rev. 2009;5:164–174.

Tannenbaum C Paquette A Hilmer S A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs Aging. 2012;29:639–658.

Lam RW Michalak EE Bond DJ Which depressive symptoms and medication side effects are perceived by patients as interfering most with occupational functioning? Depress Res Treat. 2012;630206. doi: 10.1155/2012/630206.

Culang ME Sneed JR Keilp JG Change in cognitive functioning following acute antidepressant treatment in late-life depression. Am J Geriatr Psychiatry. 2009;17:881–888.

Crossley NA Bauer M. Acceleration and augmentation of antidepressants with lithium for depressive disorders: Two meta-analyses of randomized, placebo-controlled trials. J Clin Psychiatry. 2007;68:935–940.

Spielmans GI Berman MI Linardatos E Adjunctive atypical antipsychotic treatment for major depressive disorder: A meta-analysis of depression, quality of life, and safety outcomes. PLoS Med. 2013;10:e1001403.

Pachet AK Wisniewski AM . The effects of lithium on cognition: An updated review. Psychopharmacology. 2003;170:225–234.

Arts B Jabben N Krabbendam L A 2-year naturalistic study on cognitive functioning in bipolar disorder. Acta Psychiatr Scand. 2011;123:190–205.

Torrent C Martinez-Aran A Daban C Effects of atypical antipsychotics on neurocognition in euthymic bipolar patients. Compr Psychiatry. 2011;52:613–622.

Ravindran AV Kennedy SH O'Donovan MC Osmotic-release oral system methylphenidate augmentation of antidepressant monotherapy in major depressive disorder: Results of a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry. 2008;69:87–94.

Candy M Jones L Williams R Psychostimulants for depression. Cochrane Database Syst Rev. 2008;2:CD006722.

Madhoo M Keefe RS Roth RM Lisdexamfetamine dimesylate augmentation in adults with persistent executive dysfunction after partial or full remission of major depressive disorder. Neuropsychopharmacology. 2014;39:1388–1398.

Trivedi MH Cutler AJ Richards C A randomized controlled trial of the efficacy and safety of lisdexamfetamine dimesylate as augmentation therapy in adults with residual symptoms of major depressive disorder after treatment with escitalopram. J Clin Psychiatry. 2013;74:802–809.

Goss AJ Kaser M Costafreda SG Modafinil augmentation therapy in unipolar and bipolar depression: A systematic review and meta-analysis of randomized controlled trials. J Clin Psychiatry. 2013;74:1101–1107.