The Absence of a Placebo Group is a Serious Limitation of the STAR*D Trial

Sinyor M Schaffer A Levitt A. The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Trial: A review. Can J Psychiatry. 2010;55:126–135.

Kirsch I Deacon BJ Huedo-Medina TB . Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration. PLoS Med. 2008;5:e45.

Fournier JC DeRubeis RJ Hollon SD . Antidepressant drug effects and depression severity: A patient-level meta-analysis. JAMA. 2010;303:47–53.

Posternak MA Solomon DA Leon AC . The naturalistic course of unipolar major depression in the absence of somatic therapy. J Nerv Ment Dis. 2006;194:324–329.