The theory of evolution may be relevant to psychiatric disorders. Evolution reflects changes in genes throughout time. Thus, evolutionary forces can shape any phenotype that is genetically rooted and that possesses a long history. Schizophrenia is likely an ancient condition with a substantial genetic component. Since the 1960s, several researchers have applied evolutionary principles to the study of schizophrenia. In general, schizophrenia is either viewed as an evolutionary advantageous condition or as a disadvantageous byproduct of normal brain evolution. This paper reviews major evolutionary explanations— historical and current—that speculate on the possible origins of schizophrenia.
DarwinC.On the origin of species by means of natural selection. 1st ed.London: John Murray; 1859.
2.
McGuffinPOwenMJFarmerAE. Genetic basis of schizophrenia. Lancet1995;346:678–82.
3.
KendlerKSDiehlSR. Schizophrenia: Genetics. In: KaplanHISadockBJ. editors. Comprehensive textbook of psychiatry. Volume 1. Baltimore: Williams and Williams; 1995. p 942–57.
4.
KendlerKSDiehlSR. The genetics of schizophrenia: A current, geneticepidemiologic perspective. Schizophr Bull1993;19:261–85.
5.
KendlerKSGardnerCO. The risk for psychiatric disorders in relatives of schizophrenic and control probands: A comparison of three independent studies. Psychol Med1997;27:411–9.
6.
KetySSWenderPHJacobsenBIngrahamLJJanssonL, and others. Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen study in the rest of Denmark. Arch Gen Psychiatry1994;51:442–55.
7.
TienariPJWynneLC. Adoption studies of schizophrenia. Ann Med1994;26:233–7.
8.
TienariPWynneLCMoringJLahtiINaaralaMSorriA, and others. The Finnish adoptive family study of schizophrenia: Implications for family research. Br J Psychiatry1994;23(Suppl):20–6.
9.
TorreyEFBowlerAETaylorEHGottesmanII. Schizophrenia and manicdepressive disorder. New York: Basic Books; 1994.
10.
JesteDVDel CarmenRLohrJBWyattRJ. Did schizophrenia exist before the eighteenth century?Compr Psychiatry1985;26:493–503.
11.
ShorterE.A history of psychiatry. New York: John Wiley & Sons; 1997.
12.
KingdonJ.Self made man. New York: John Wiley & Sons; 1993.
13.
MowryBJLennonDPDe FeliceCN. Diagnosis of schizophrenia in a matched sample of Australian aborigines. Acta Psychiatr Scand1994;90:337–41.
14.
TorreyEF. Prevalence studies in schizophrenia. Br J Psychiatry1987;150:598–608.
15.
JablenskyASartoriusNErnbergGAnkerMKortenACooperJE, and others. Schizophrenia: Manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med (Monogr Suppl)1992;20:1–97.
16.
FarleyJD. Phylogenetic adaptations and the genetics of psychosis. Acta Psychiatr Scand1976;53:173–92.
17.
RandallPL. Schizophrenia, abnormal connection, and brain evolution. Med Hypotheses1983;10:247–80.
18.
RandallPL. Schizophrenia as a consequence of brain evolution. Schizophr Res1998;30:143–8.
19.
MillarTP. Schizophrenia: An etiological speculation. Perspect Biol Med1987;30:597–607.
20.
AndreasenNCParadisoSO'LearyDS. “Cognitive Dysmetria” as an integrative theory of schizophrenia: A dysfunction in cortical-subcortical-cerebellar circuitry?Schizophr Bull1998;24:203–11.
21.
CrowTJ. The continuum of psychosis and its genetic origins. Br J Psychiatry1990;156:788–97.
22.
CrowTJ. The origins of psychosis and “The Descent of Man.”Br J Psychiatry1991;159:14(Suppl):76–82.
23.
CrowTJ. Sexual selection, Machiavellian intelligence, and the origins of psychosis. Lancet1993;342:594–8.
24.
CrowTJ. A Darwinian approach to the origins of psychosis. Br J Psychiatry1995;167:12–25.
25.
CrowTJ. Aetiology of schizophrenia: An evolutionary theory. Int Clin Psychopharmacol1995;10(Suppl 3):49–56.
26.
CrowTJ. Is schizophrenia the price that Homo sapiens pays for language?Schizophr Res1997;28:127–41.
27.
CrowTJ. Schizophrenia as the price that Homo sapiens pays for language: A resolution of the central paradox in the origin of the species. Brain Res Brain Res Rev2000;31:118–29.
28.
EldredgeNGouldSJ. Punctuated equilibria: An alternative to phyletic gradualism. In: SchopfTJM, editor. Models in paleobiology. San Francisco: Freeman, Cooper and Co; 1972. p 82–115.
DeaconT.The symbolic species. New York and London: WW Norton & Company; 1997.
31.
YeoRAGangestadSWEdgarCThomaR.The evolutionary genetic underpinnings of schizophrenia: The developmental instability model. Schizophr Res1999;39:197–206.
32.
SaugstadLF. A lack of cerebral lateralization in schizophrenia is within the normal variation in brain maturation but indicates late, slow maturation. Schizophr Res1999;39(3):183–93.
33.
WilsonDSSoberE.Reintroducing group selection to the human behavioral sciences. Behav Brain Sci1994;17:585–654.
34.
HuxleyJMayrEOsmondHHofferA.Schizophrenia as a genetic morphism. Nature1964;204:220–1.
35.
TorreyEF. Prevalence studies in schizophrenia. Br J Psychiatry1987;150:598–608.
36.
NicholiAMJr.The Harvard Guide to Psychiatry. Cambridge (MA): Harvard University Press; 1999.
37.
NimgaonkarVL. Reduced fertility in schizophrenia: Here to stay?Acta Psychiatr Scand1998;98:348–53.
38.
SuvisaariJMHaukkaJKTanskanenAJLonnqvistJK. Decline in the incidence of schizophrenia in Finnish cohorts born from 1954 to 1965. Arch Gen Psychiatry1999;56:733–40.
PostF.Creativity and psychopathology: A study of 291 world-famous men. Br J Psychiatry1994;165:22–34.
54.
AllenJ SSarichVM. Schizophrenia in an evolutionary perspective. Perspect Biol Med1988;32:132–53.
55.
HorrobinDF. Schizophrenia: The illness that made us human. Med Hypotheses1998;50:269–88.
56.
HorrobinDF. Lipid metabolism, human evolution and schizophrenia. Prostaglandins Leukot Essent Fatty Acids1999;60:431–7.
57.
SoaresJCInnisRB. Neurochemical brain imaging investigations of schizophrenia. Biol Psychiatry1999;46:600–15.
58.
StevensAPriceJ.Evolutionary psychiatry. London and Philadelphia: Routledge; 2000.
59.
PolimeniJReissJ.How shamanism and group selection may reveal the origins of schizophrenia. Med Hypotheses2002;58:244–8.
60.
BrewertonT.Hyperreligiosity in psychotic disorders. J Nerv Ment Dis1994;182:301–4.
61.
MoslowskiJvan RensburgD JansenMthokoN.A polydiagnostic approach to the differences in symptoms of schizophrenia in different cultural and ethnic populations. Acta Psychiatr Scand1998;98:41–6.
62.
HoltvedE.Eskimo shamanism. In: EdsmanCM, editor. Studies in shamanism: Based on papers read at the Symposium on Shamanism held at Abo. 1962 Sept 6–8, 1962; Stockholm: Almqvist & Wiksell1967; p 23–31.
