Restricted accessResearch articleFirst published online 1998-9
Diabetic Polyneuropathy and the Genetics of Signal Transduction. Evidence of Association with Cytosolic Low Molecular Weight Phosphotyrosine-Phosphatase
We have studied 263 subjects with non-insulin-dependent diabetes mellitus (NIDDM) and have found a highly significant interaction between cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP) and RhE genotypes concerning their effects on polyneuropathy.
A discriminant analysis has revealed two distinct clusters of subjects with neuropathy differing for both cLMWPTP and RhE genotypes. A high glycemic level is present in one cluster only, suggesting that genetic variability of signal transduction may have an important role especially in patients developing neuropathy in spite of a satisfactory metabolic control of diabetes.
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