Abstract
The effects of vinpocetine (VP), a proposed modulator of production of arachidonic acid metabolites, on disease development and immune functions in rats with adjuvant-induced arthritis (AA) were investigated. Daily i.p. administration of VP (25 mg/kg/for 14 days) to rats with adjuvant-induced arthritis significantly reduced both edema and bone erosion in the hindpaws. After the administration of vinpocetine a decrease of serum hyaluronic acid levels, active lymphocyte number and increase of serum albumin levels were found. Decrease in urine biopterin levels were normalised after treatment with VP.
In conclusion, vinpocetine was shown to have antiinflammatory and antiarthritic effects in rats.
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