This paper describes the experiments conducted in our laboratory on the mode of activation of CD5 + B cells. The data show that these cells are stimulated in a manner that is less dependent of T cell help as compared to CD5- cells and define IL-2 as the major growth and differentiation factor for CD5 + cells. These data are discussed in the light of the supposed function of CD5 + cells that seem represented by the capacity to release polyspecific antibodies reacting with a multiplicity of antigens from various pathogens. These antibodies, also called natural antibodies, probably represent one of the first line of defense against invading microrganisms.
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