48 patients suffering from classic erosive RA with conditions persisting for more than 6 years were examined together with 69 healthy control subject with regard to associations to supertypic HLA-D specificities. We found a significant increase of HLA-DRw53 in patients with RF positive RA (22/31 pat. = 71%,Chi2 = 13.2, p<0.01). Our results confirm the hypothesis that the HLA-DRβ2 chain gene is closer related to the disease susceptibility of seropositive RA than the DRβ1 chain gene (DR4).
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