Morniflumate is the morpholinoethyl ester of niflumic acid, a non-steroidal antiinflammatory drug, derived from nicotinic acid. We studied 112 patients who had experienced cutaneous reactions after using non-steroidal anti-inflammatory drugs. Only two of all the patients who underwent an oral challenge with morniflumate had a positive result to the test. By demonstrating the low incidence of reactions to morniflumate through oral challenges, we suggest that patients with non-steroidal anti-inflammatory drug hypersensitivity may tolerate this drug which would therefore be a useful alternative.
SettipaneGA. Aspirin and allergic diseases: A review. Am J Med1983; 74:102–9.
2.
SettipaneGA. Aspirin sensivity and allergy. Biomed Pharmacother1988; 42:493–8.
3.
HoignéRSchlumbergerHPVervloetDZoppiM. Epidemiology of allergic drug reactions. Monogr Allergy1993; 31:147–70.
4.
SmithWLDeWittDL. Biochemistry of prostaglandin endoperoxe H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs. Semin Nephrol1995; 15:179–94.
5.
FrolichJC. A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol Sci1997; 18:30–4.
6.
KowalskiMLMakowskaJSBlancaM. Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: Review of the EAACI/ENDA and GA2LEN/HANNA. Allergy2011; 66:818–29.
CivelliMViganoTAcerbiDCarusoPGiossiMBongraniSFolcoGC. Modulation of arachidonic acid metabolism by orally administered morniflumate in man. Agents Actions1991; 33:233–9.
9.
SchlantareiliPCadelSAcerbiD. A gastroprotectiva antiinflammatory agent: The beta-morpholinoethyl ester of niflumic acid (morniflumate). Agents Actions1984; 14:247–56.
10.
ManachYDitisheimA. Double-blind, placebo-controlled multicentre trial of the efficacy and tolerance of morniflumate suppositories in the treatment of tonsillitis in children. J Int Med Res1990; 18:30–6.
11.
SturkenboomMNicolosiACantaruttiLManninoSPicelliGScamarciaAGiaquintoC; NSAIDs Paediatric Research Group. Incidence of mucocutaneous reactions in children treated with niflumic acid, other nonsteroidal antiinflammatory drugs, or non opioid analgesics. Pediatrics2005; 116:e26–33.
12.
NettisEDi PaolaRNapoliGFerranniniATursiA. Benzydamine: An alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria. Allergy2002; 57:442–5.
13.
SennaGEPassalacquaGDamaACrivellaroMSchiappoliMBonadonnaPCanonicaGW. Nimesulide and meloxicam are a safe alternative drugs for patients intolerant to nonsteroidal anti-inflammatory drugs. Eur Ann Allergy Clin Immunol2003; 35:393–6.
14.
AseroR. Etoricoxib challenge in patients with chronic urticaria with NSAID intolerance. Clin Exp Dermatol2007; 32:661–3.
15.
AseroR. Clinical management of adult patients with a history of nonsteroidal anti-inflammatory drug-induced urticaria/angioedema: Update. Allergy Asthma Clin Immunol2007; 3:24–30.
