Athletes who undergo strenuous exercise, especially in endurance sports, frequently use herbal supplements in order to have a better performance. In this review we try to find out if the most common herbal supplements (Echinacea, Rhodiola, Ginseng) are effective in the empowerment of perfomance or in the modulation of the immune system. It seems that the prevalent effect is adaptogenic rather than ergogenic, with a better tolerance of the exercise induced stress, related to enhancement of the whole immune system and decrease of the oxidative damage.
ShevtsovVAZholusBIShervarlyVIVol'skijVBKorovinYPKhristichMPRoslyakovaNAWikmanG. “A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work Phytomedicine”. 2003 Mar;10(2–3):95–105.
4.
DarbinyanVKteyanAPanossianAGabrielianEWikmanGWagnerH. “Rhodiola rosea in stress induced fatigue—a double blind cross-over study of a standardized extract with a repeated low-dose regimen on the mental performance of healthy physicians during night duty”. Phytomedicine7.Oct 2000 (5): 365–71.
5.
HaZZhuYZhangXCuiJZhangSMaYWangWJianX.“The effect of rhodiola and acetazolamide on the sleep architecture and blood oxygen saturation in men living at high altitude”Zhonghua Jie He He Hu Xi Za Zhi200225 (9): 527–30.
6.
GregorySKellyND. “Rhodiola rosea: A possible plant adaptogen.”. Alternative Medicine Review6. 2001. (3): 293–302.
7.
De BockKEijndeBORamaekersMHespelP. “Acute Rhodiola rosea intake can improve endurance exercise performance”. Int J Sport Nutr Exerc Metab. Jun 2004. 14 (3): 298–307.
8.
DarbinyanVAslanyanGAmroyanEGabrielyanEMalmströmCPanossianA. “Clinical trial of Rhodiola rosea L. extract in the treatment of mild to moderate depression”. Nord J Psychiatry. 2007. 61 (5): 343–8.
9.
LiuQLiuZLTianX. “Phenolic components from Rhodiola dumulosa”. Zhongguo Zhong Yao Za Zhi. Feb 2008. 33(4): 411–3.
10.
Skarpanska-StejnbornAPilaczynska-SzczesniakLBastaP, Deskur-Smielecka E. The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers. Int J Sport Nutr Exerc Metab. 2009 Apr; 19(2):186–99.
11.
ParisiATranchitaEDurantiGCiminelliEQuarantaFCeciRCerulliCBorrionePSabatiniS. Effects of chronic rhodiola rosea supplementation on sport performance and antioxidant capacity in trained male: Preliminary results. J Sports Med Phys Fitness. 2010 Mar;50(1):57–63.
12.
KucinskaiteABriedisVSavickasA, “Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine”. 2004Medicina (Kaunas)40 (7): 614–9.
13.
MillerSCDelormeDShanJJ. CVT-E002 stimulates the immune system and extends the life span of mice bearing a tumor of viral origin. J Soc Integr Oncol. 2009 Fall;7(4):127–36.
14.
LiHXSzeSCTongYNgTB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol. 2009 Jun 22;123(2):257–66. Epub 2009 Mar 20.
15.
Physical exercise and the immune system. RanieriMMegnaMLancioniGEJirilloEAmicoAPNardulliMStasiMIanieriGSagginiAMegnaG. Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3 Suppl):29–32.
16.
SenchinaDSMartinAEBussJEKohutML. Effects of Echinacea extracts on macrophage antiviral activities. Phytother Res. 2009 Dec 29. [Epub ahead of print]
17.
SenchinaDSShahNBDotyDMSandersonCRHallamJE. Herbal supplements and athlete immune function—what's proven, disproven, and unproven?Exerc Immunol Rev. 2009;15:66–106.
18.
SenchinaDSHallamJEDiasASPereraMA. Human blood mononuclear cell in vitro cytokine response before and after two different strenuous exercise bouts in the presence of bloodroot and Echinacea extractsBlood Cells Mol Dis. 2009 Nov-Dec;43(3):298–303. Epub 2009 Sep 19.
19.
BurnsJJZhaoLTaylorEWSpelmanK. The influence of traditional herbal formulas cytokine activity. Toxicology. 2009 Oct 7. [Epub ahead of print]
20.
BensonJMPokornyAJRhuleAWennerCAKandhiVCechNBShepherdDM. Echinacea purpurea extracts modulate murine dendritic cell fate and function. Food Chem Toxicol. 2010 Feb 10. [Epub ahead of print]
21.
LaLoneCARizshskyLHammerKDWuLSolcoAKYumMNikolauBJWurteleESMurphyPAKimMBirtDF. Endogenous levels of Echinacea alkylamides and ketones are important contributors to the inhibition of prostaglandin E2 and nitric oxide production in cultured macrophages. J Agric Food Chem. 2009 Oct 14;57(19):8820–30.
22.
HsuCCHoMCLinLCSuBHsuMC. American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings. World J Gastroenterol. 2005 Sep 14;11(34):5327–31.
23.
KimSHParkKSChangMJSungJH. Effects of Panax ginseng extract on exercise-induced oxidative stress. J Sports Med Phys Fitness. 2005 Jun;45(2):178–82.
24.
KulaputanaOThanakomsirichotSAnomasiriW. Ginseng supplementation does not change lactate threshold and physical performances in physically active Thai men. J Med Assoc Thai. 2007 Jun;90(6): 1172–9.
25.
EngelsHJKolokouriICieslakTJ2ndWirthJC. Effects of ginseng supplementation on supramaximal exercise performance and short-term recovery. J Strength Cond Res. 2001 Aug;15(3):290–5.
26.
ZiembaAWChmuraJKaciuba-UscilkoHNazarKWisnikPGawronskiW. Ginseng treatment improves psychomotor performance at rest and during graded exercise in young athletes. Int J Sport Nutr. 1999 Dec;9(4):371–7.
27.
SongXZangLHuS. Amplified immune response by ginsenoside-based nanoparticles (ginsomes). Vaccine. 2009 Apr 14;27(17):2306–11. Epub 2009 Feb 24
28.
SongXHuS, Adjuvant activities of saponins from traditional Chinese medicinal herbs. Vaccine. 2009 Aug 6;27(36):4883–90. Epub 2009 Jun 24.
29.
EngelsHJWirthJC. No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exercise. J Am Diet Assoc. 1997 Oct;97(10):1110–5.
30.
EngelsHJFahlmanMMWirthJC. Effects of ginseng on secretory IgA, performance, and recovery from interval exercise. Med Sci Sports Exerc. 2003 Apr;35(4):690–6.
31.
MillerSCDelormeDShanJJ. CVT-E002 stimulates the immune system and extends the life span of mice bearing a tumor of viral origin. J Soc Integr Oncol. 2009 Fall;7(4):127–36.
32.
WangLCLeeTF. Effect of ginseng saponins on exercise performance in non-trained rats. Planta Med. 1998 Mar;64(2):130–3.
PannacciMLuciniVColleoniFMartucciCGrossoSSacerdotePScaglioneF. Panax ginseng C.A. Mayer G115 modulates pro-inflammatory cytokine production in mice throughout the increase of macrophage toll-like receptor 4 expression during physical stress. Brain Behav Immun. 2006 Nov;20(6):546–51. Epub 2006 Feb 15.
35.
MinYKChungSHLeeJSKimSSShinHDLimBVShinMCJangMHKimEHKimCJ, Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of rats. J Pharmacol Sci. 2003 Oct;93(2):218–21.
36.
VocesJde OliveiraAC CabralPrietoJGVilaLPerezACDuarteIDAlvarezAI. Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats. Braz J Med Biol Res. 2004 Dec;37(12):1863–71. Epub 2004 Nov 17.
37.
de OliveiraAC CabralPerezACPrietoJGDuarteIDAlvarezAI. Protection of Panax ginseng in injured muscles after eccentric exercise. J Ethnopharmacol. 2005 Feb 28;97(2):211–4. Epub 2005 Jan 13.
38.
de OliveiraAC CabralPerezACMerinoGPrietoJGAlvarezAI. Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Nov;130(3):369–77.
39.
GaffneyBTHãügelHM, Rich PAThe effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sci. 2001 Dec 14;70(4):431–42.
40.
HwangHJKwakYSYoonGAKangMHParkJHLeeBKKimSJUrnSYKimYM. Combined effects of swim training and ginseng supplementation on exercise performance time, ROS, lymphocyte proliferation, and DNA damage following exhaustive exercise stress. Int J Vitam Nutr Res. 2007 Jul;77(4):289–96.
41.
YangYWuTHeKFuZGYaoZhongguoBaoLi Xue. Effect of aerobic exercise and ginsenosides on lipid metabolism in diet-induced hyperlipidemia mice. 1999 Jun;20(6):563–5.
42.
BentlerSEHartzAJ, Kuhn EMProspective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005 May;66(5):625–32.
43.
SmithAEFukudaDHKendallKLStoutJR. The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance. J Int Soc Sports Nutr. 2010 Feb 15;7(1):10. [Epub ahead of print]
44.
AllenJDMcLungJNelsonAGWelschM. Ginseng supplementation does not enhance healthy young adults' peak aerobic exercise performance. J Am Coll Nutr. 1998 Oct;17(5):462–6.
45.
GouletEDDionneIJ. Assessment of the effects of eleutherococcus senticosus on endurance performance. Int J Sport Nutr Exerc Metab. 2005 Feb;15(1):75–83.
46.
KangH YoulKimS HwanLeeW JunByrneHK. Effects of ginseng ingestion on growth hormone, testosterone, Cortisol, and insulin-like growth factor 1 responses to acute resistance exerciseJ Strength Cond Res. 2002 May; 16(2): 179–83.
47.
BiondoPDRobbinsSJWalshJDMcCargarLJHarberVJFieldCJ. A randomized controlled crossover trial of the effect of ginseng consumption on the immune response to moderate exercise in healthy sedentary men. Appl Physiol Nutr Metab. 2008 Oct;33(5):966–75.
48.
BahrkeMSMorganWPStegnerA. Is ginseng an ergogenic aid?Int J Sport Nutr Exerc Metab. 2009 Jun;19(3):298–322.
49.
MorrisACJacobsIMcLellanTMKlugermanAWangLCZamecnikJ. No ergogenic effect of ginseng ingestion. Int J Sport Nutr. 1996 Sep;6(3):263–71
