In literature many different therapies are proposed to treat Monilethrix, but a definitive therapy still doe not exist. We decided to treat four patients affected by Monilethrix, with topical minoxidil 2%, 1 ml night and day for 1 year. Minoxidil led to a an increase of normal hair shaft without any side effects in all the patients. Therefore topical minoxidil 2% could be considered a good therapy to treat Monilethrix.
DjabaliKPanteleyevAALalinTGarzonMCLongleyBJBickersDRZlotogorskitAChristianoAM. Recurrent missense mutations in the hair keratin gene hHb6 in Monilethrix. Clin Exp Dermatol2003; 28:206–10.
2.
WinterHRogersMAGebhardtM. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder Monilethrix. Hum Genet1997; 101:165–69.
3.
HorevLGlaserBMetzkerAAmitaiDVardyDZlotogorskiA. Monilethrix: mutational hotspot in the helix termination motif of the human hair basic keratin 6. Human Heredity2000; 50:325–30.
4.
ZlotogorskiAHorevLGlaserB. Monilethrix: a keratin hHb6 mutation is co-dominant with variable expression. Exp Dermatol1998; 7:268–72.
5.
ItoMHashimotoKKatsuumiKSatoY. Pathogenesis of Monilethrix: computer stereography and electron microscopy. J Invest Dermatol1990; 95:186–94.
6.
ItoMHashimotoKYorderFW. Monilethrix: an ultrastructural study. J Cutan Pathos1984; 11:513–21.
7.
WinterHClarkRDTarras-WahibergCRogersMASchweizerJ. Monilethrix: A novel mutation(Glu402Lys) in the helix termination motif and the first causative mutation(Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6. J Invest Dermatol1999; 113:263–66.
8.
DuarteDPde AlmeidaFA. Uso do minoxidil topico no moniletrix. An bras Dermatol, Rio de Janeiro1997;72:84–92.
9.
SaxenaURameshVMisraRS. Topical minoxidil in Monilethrix. Dermatologica1991; 182:252–3.