Clopidogrel is a potent inhibitor of platelet aggregation and has been used as an alternative, or as an adjunct to aspirin in reducing the risk of thrombosis. A 34-year-old uremic type 1 male diabetic patient who underwent simultaneous kidney-pancreas transplantation was given clopidogrel as he was allergic to aspirin. He developed polyarthralgia one week later, followed in a few days by symmetrical migratory polyarthritis, which resolved completely on withdrawing the drug. The implications to clinical management in a transplant setting are discussed.
LufftV.DannenbergB.SchlittH.J.PichlmayrR.BrunkhorstR., 2004. Cardiovascular morbidity and mortality in patients with diabetes mellitus type I after kidney transplantation: A case-control study. Clin. Nephrol.61:238.
GargA.RadvanJ.HopkinsonN., 2000. Clopidogrel associated with acute arthritis. BMJ320:483.
4.
PhillipsE.J.KnowlesS.R.ShearN.H., 2003. Serum sickness-like reaction associated with Clopidogrel. Br. J. Clin. Pharmacol.56:583.
5.
LarsenJ.2004. Pancreas transplantation: Indications and consequences. Endocr. Rev.25:919.
6.
ChinnakotlaS.LeoneJ.P.FidlerM.E.HammekeM.D.TarantoloS., 2000. Clopidogrel-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in a kidney/pancreas transplant recipient. Transplantation70:550.
7.
EvensA.M.KwaanH.C.KaufmanD.B.BennettC.L., 2002. TTP/HUS occurring in a simultaneous pancreas/kidney transplant recipient after Clopidogrel treatment: Evidence of a non-immunological etiology. Transplantation74:885.
