Sage Journals: Discover world-class research

Abstract

Sixteen strains of physiological and pathological vaginal bacteria were tested for their ability to secrete histamine from rat peritoneal mast cells in vitro. We noticed that Mycoplasma hominis -induced histamine release was very high (up to 53.6%). The stimulation of rat mast cells with Staphylococccus cohnii, Staphylococcus coagulase(-) (two strains), Ureaplasma urealyticum, Peptostreptococcus spp., Bacteroides capillosus, Staphylococcus aureus and Streptococcus agalactiae resulted in lower, but significant histamine secretion (11.2%–17.5%). Other bacterial strains (Staphylococcus epidermidids, Enterococcus faecalis, Escherichia coli, Actinomyces naeslundii (two strains) and Lactobacillus fermentum (two strains) caused very low (4.2 % – 8.8%) histamine release.

Keywords

Vaginal bacterial flora mast cells histamine release bacterial vaginosis

References

Gordon

J.R.

Burd

P.R.

and Galli

S.J.

. 1990. Mast cells as a source of multifunctional cytokines. Immunol. Today 11: 458.

Galli

S.J.

1993. New concepts about the mast cell. N. Engl. J. Med. 328: 257.

Schwartz

L.B.

1994. Mast cells: function and contents. Curr. Opin. Immunol. 6:91.

Irani

A.-M.A.

1997. Ocular mast cells and mediators. Immunol. Allergy Clin. N. Am. 17:1.

Galli

S.J.

and Wershil

B.K.

. 1996. The two faces of the mast cell. Nature 381:21.

MacDonald

A.J.

Wills

F.L.

Lin

T.-J.

and Befus

A.D.

. 1998. The role of mast cells in inflammation and homeostasis. In Allergy and Allergic Diseases. The New Mechanisms and Therapeutics. Denburg

J.A.

, ed. Human Press Totowa New Jersey, p. 103.

Landry

Bronner

Mousli

Fischer

and Valle

. 1992. The activation of mast cells: molecular targets and transducing processes for antigenic and non-antigenic stimuli. Bull. Inst. Pasteur 90: 83.

Malaviya

and Abraham

S.N.

. 1998. Clinical implications of mast cell-bacteria interaction. J. Mol. Med. 76: 617.

Abraham

S.N.

and Malaviya

. 1997. Mast cells in infection and immunity. Infect. Immun. 65: 3501.

10.

Rossow

Savoly

S.B.

Repke

and Odarjuk

. 1986. Monoclonal antibodies against rat mast cells. Biomed. Biochim. Acta 45: 1343.

11.

Shore

P.A.

Burkhalter

and Cohn

V.H.

. 1959. A method for the fluorometric assay of histamine in tissues. J. Pharmacol. Exp. Ther. 127: 182.

12.

Jensen

Norn

Skov

S.P.

Espersen

Koch

and Permin

. 1984. Bacterial histamine release by immunological and non-immunological lectin-mediated reactions. Allergy 39: 371.

13.

Norn

Skov

S.P.

Jensen

Bog-Hansen

T.C.

Lihme

Espersen

and Permin

. 1984. Lectin-mediated reactions in histamine release caused by bacteria. Agents Actions 14: 481.

14.

Malaviya

Ross

Jakschik

B.A.

and Abraham

S.N.

. 1994. Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice. J. Clin. Invest. 93: 1645.

15.

Bechi

Dei

Di Bello

M.G.

and Masini

. 1993. Helicobacter pylori potentiates histamine release from serosal rat mast cells in vitro. Dig. Dis. Sci. 38: 944.

16.

Lutton

D.A.

Bamford

K.B.

O'Loughlin

and Ennis

. 1995. Modulatory action of Helicobacter pylori on histamine release from mast cells and basophils in vitro. J. Med. Microbiol. 42: 386.

17.

Masini

Bechi

Dei

Di Bello

M.G.

and Sacchi

T.B.

. 1994. Helicobacter pylori potentiates histamine release from rat serosal mast cells induced by bile acids. Dig. Dis. Sci. 39: 1493.

18.

Brzezinska-Blaszczyk

and Olejnik

A.K.

. 1999. Intestinal mucosa-associated bacteria modulate rat mast cell reactivity. Int. J. Immunopathol. Pharmacol. 12:31.

19.

Church

M.K.

Norn

Pao

G.J.

and Holgate

S.T.

. 1987. Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. Clin. Allergy 17: 341.

20.

Brzezinska-Blaszczyk

Gaik

Czuwaj

and Kuna

. 1988. Histamine release from human pulmonary mast cells induced by bacterial antigens. Allergol. Immunopathol. 16:375.

21.

Brzezinska-Blaszczyk

Czuwaj

and Wyczolkowska

. 1988. Histamine release from human adenoidal and mesenteric mast cells induced by bacterial antigens. Agents Actions 23: 230.

22.

Scheffer

Konig

Braun

and Goebel

. 1988. Comparison of four hemolysin-producing organisms (Escherichia coli, Serratia marcescens, Aeromonas hydrophila, and Listeria monocytogenes) for release of inflammatory mediators from various cells. J. Clin. Microbiol. 26: 544.

23.

Miyoshi

Sugiyama

Furuta

Miyoshi

and Shinoda

. 1986. Histamine release from rat mast cells by Vibrio vulnificus protease. FEMS Microbiol. Lett. 34: 301.

24.

Nygren

and Dahlen

. 1981. Complement-dependent histamine release from rat peritoneal mast cells, induced by lipopolysaccharides from Bacteroides oralis, Fusobacterium nucleatum and Veillonella parvula. J. Oral. Pathol. 10: 87.

25.

Calderon

G.M.

Torres-Lopez

Lin

T.-J.

Chavez

Hernandez

Munoz

Befus

A.D.

and Enciso

J.A.

. 1998. Effects of toxin A from Clostridium difficile on mast cell activation and survival. Infect. Immun. 66: 2755.

26.

Komisar

Rivera

Vega

and Tseng

. 1992. Effects of staphylococcal enterotoxin B on rodent mast cells. Infect. Immun. 60: 2969.

27.

Patella

Casolaro

Bjorck

and Marone

. 1990. Protein L. A bacterial Ig-binding protein that activates human basophils and mast cells. J. Immunol. 145: 3054.

28.

Wex

C.B.A.

Koch

and Aktories

. 1997. Effects of Clostridium difficile toxin B on activation of rat peritoneal mast cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 355: 328.

29.

McGregor

J.A.

French

J.I.

Richter

Franco-Buff

Johnson

Hillier

Judson

F.N.

and Todd

J.K.

. 1990. Antenatal microbiologic and maternal risk factors associated with prematurity. Am. J. Obstet. Gynecol. 163: 1465.

30.

Colli

Bertulessi

Landoni

and Parazzini

. 1996. Bacterial vaginosis in pregnancy and preterm birth: evidence from the literature. J. Inter. Med. Res. 24: 317.

31.

Lamont

R.F.

Taylor-Robinson

Newman

Wigglesworth

and Elder

M.G.

. 1986. Spontaneous early preterm labour associated with abnormal genital bacterial colonization. Br. J. Obstet. Gynaecol. 93: 804.

32.

Martius

and Roos

. 1996. The role of urogenital tract infections in the etiology of preterm birth: a review. Arch. Gynecol. Obstet. 258: 1.

33.

Spiegel

C.A.

1991. Bacterial vaginosis. Clin. Microbiol. Rev. 4: 485.

34.

Jeziorska

Salamonsen

L.A.

and Woolley

D.E.

. 1995. Mast cell and eosinophil distribution and activation in human endometrium throughout the menstrual cycle. Biol. Reprod. 53: 312.

35.

Mori

Zhai

Y.L.

Toki

Nikaido

and Fujii

. 1997. Distribution and heterogeneity of mast cells in the human uterus. Hum. Reprod. 12: 368.

36.

Massey

W.A.

Guo

C.B.

Dvorak

A.M.

Hubbard

W.C.

Bhagavan

B.S.

Cohan

V.L.

Warner

J.A.

Kagey-Sobotka

and Lichtenstein

L.M.

. 1991. Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology. J. Immunol. 147: 1621.

37.

Purcell

W.M.

and Hanahoe

T.H.

. 1991. A novel source of mast cells: the human placenta. Agents Actions 33: 8.

38.

Marx

Arck

Kieslich

Mitterlechner

Kapp

and Dietl

. 1999. Decidual mast cells might be involved in the onset of human first-trimester abortion. Am. J. Reprod. Immunol. 41: 34.

Vaginal Bacterial Flora Activates Rat Peritoneal Mast Cells

Abstract

Keywords

References