Danni microvascolari nell'impotenza erettile di “origine psicogena”

Abstract

Erectile impotence is one of the major reasons for uro-andrological consultation. Countless experimental and clinical data are by now available regarding the importance of the pathologies of penile microcirculation as primitive cause of erectile dysfunction with the result that microangiological evaluation in andrology is being used more and more. Up to the present, however, there has been a lack of data related to the action of penile manipulation “in itself (necessary for correct topical application of substances with microvasculokinetic action) on the contractile activity of the arterioles examined by Laser-Doppler Flow. This report gives the results of a clinical study on 400 patients with erectile dysfunction treated with topically administered microvasculokinetic therapies. All the patients underwent a complete microangiological assessment to detect the presence of microcirculatory pathologies responsible for the erectile dysfunction. In a double blind study three different substances were used topically: two proved to nave microvasculokinetic activity with a different duration of action, while the third was totally inert. The first two increased the penile arteriolar contractile capacity in all the patients, while the third had no effect, showing that manipulation “in itself has no effect which helps increase penile arteriolar sphygmic activity. Furthermore, the different duration of action between the two substances acting on the microcirculation highlights the importance of using suitably complexed molecules for crossing the cutaneous barrier and reaching the site of action in patients who respond positively to the microvasculokinesis test.