Abstract
Interleukin-1 is a polypeptide mediator involved in the regulation of inflammatory responses. Mesangial cells IL-1 may act as an autocrine growth factor (Lovett et al., 1983). The local release of such growth factors may be important in the development of mesangial proliferative lesions characteristic of many forms of immune-mediated glomerulonephritis (Lovett et al., 1986). Secretion of IL-1 in urine specimens of renal transplant recipients with acute rejection was studied using matrix APAAP dot-blot assay, to determine any alteration of IL-1 changes that could reveal any pathological correlation. Twelve urine specimens from 6 persons with acute rejection revealed IL-1 staining in the dot-blot assay while there was no staining for IL-1 in the urine specimens of healthy persons. The immunological changes correlated with acute renal rejection could lead to autocrine and apocrine secretion of IL-1 its secretion in urine.
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