Restricted accessResearch articleFirst published online 1995
Benign prostatic hyperplasia with PSA > 10.0 ng/ml: Correlations between PSA density and pathological findings of the surgical specimen after open prostatectomy
— Thirty patients with benign prostatic hyperplasia and PSA levels > 10.0 ng/ml were submitted to open prostatectomy after a precise evaluation with transrectal ultrasound and prostatic biopsies. In the surgical specimen 7 prostatic carcinoma (23%) were found incidentally. In the remaining 23 patients the presence of active histological prostatitis was correlated with the PSA and PSA density values but was not directly due to an asymptomatic urinary infection or indwelling catheter. PIN and other pathological findings were not found to be correlated with PSA values.
BensonM.C., OlssonC.A.: Prostate specific antigen and prostate specific antigen density. Cancer, 74: 1667–73, 1994.
2.
BogdanowiczJ.F., BentvelsenF.M., OosteromR., SchroederF.H.: Evaluation of prostate specific antigen and prostatic acid phosphatase in untreated prostatic carcinoma and benign prostatic hyperplasia. Scand. J. Urol. Nephrol., 138 (suppl.): 97, 1991.
3.
WehnerN., GrandboisK., StameyT.: Clinical utility of the ACS PSA assay for prostate cancer. Cancer, 39 (6): 1189, 1993.
4.
StameyT.A., ChenZ., PrestigiacomoA.: Serum prostate specific antigen binding α1-antichymotrypsin: influence of cancer volume, location and therapeutic selection of resistant clones. J. Urol., 152: 1510–1514, 1994.
5.
HasuiY., MarutsukaK., AsadaY., IdeH., NishiS., OsadaY.: Relationship between serum prostate specific antigen and histological prostatitis in patients with benign prostatic hyperplasia. Prostate, 25: 91–96, 1994.
6.
ShinoharaK., WheelerT., ScardinoP.T.: The appearance of prostatic cancer on transrectal ultrasonography: correlation of imaging and pathological examination. J. Urol., 142: 76, 1989.
7.
EllisW.J., ChetnerM.P., PrestonS.D., BrawerM.K.: Diagnosis of prostatic carcinoma: the yield of serum prostate specific antigen, digital rectal examination and transrectal ultrasonography. J. Urol., 152: 1520–1525, 1994.
BrawerM.K., RennelsM.A., NagleR.B., SchifmanR., GainesJ.A.: Serum prostate specific antigen and prostate pathology in men having simple prostatectomy. Am. J. Clin. Pathol., 92: 760–764, 1989.
10.
GlenskiW.J., MalekR.S., MyrtleJ.F., OesterlingJ.E.: Sustained substantially increased concentration of prostate specific antigen in the absence of prostatic malignant disease: An unusual clinical scenario. Mayo Clin. Proc., 67: 249–252, 1992.
11.
EllisW.J., BrawerM.K.: PSA in benign prostatic hyperplasia and prostatic intraepithelial neoplasia. Urol. Clin. North Am., 20 (4): 621–625, 1993.
