Tissue prognosticators in radical prostatectomy specimens are studied. In general the morphological features of histologic grade, pathologic stage and tumour extension are universally accepted. New prognostic tissue markers are being developed. It will be interesting to know if there is independent prognostic significance in direct multivariate analyses to develop fast and inexpensive methods. An essential review of literature is presented.
WhitmoreW.F. Jr.: Hormone therapy in prostatic cancer. Am. J. Med., 21: 697–713, 1956.
9.
JewettH.J.: The present status of radical prostatectomy for stages A and B prostatic cancer. Urol. Clin. North Am., 2: 105–124, 1975.
10.
) American Joint Committee on Cancer. Manual for Staging of Cancer. Second ed. Philadelphia: J.B. Lippincott, p. 159, 1983.
11.
HermanekP., SobinJ.H.: Urological tumours. In: TNM classification of malignant tumors. New York, Springer-Verlag, pp. 121–126, 1987.
12.
PaulsonD.F., MoulI.W., WaltherP.J.: Radical prostatectomy for clinical stage T1-2N0M0 prostatic adenocarcinoma. Long-term results. J. Urol., 144: 1880–1184, 1990.
13.
VogesG.E., McNealJ.E., RedwineE.A.: Morphologic analysis of surgical margins with positive findings in prostatectomy for adenocarcinoma of the prostate. Cancer, 69: 520–526, 1992.
14.
JonesE.C.: Resection margin status in radical retropubic prostatectomy specimens: relationship to type of operation, tumour size, tumour grade and local tumour extension. J. Urol., 144: 89–93, 1990.
15.
StameyT.A., VillersA.A., McNealJ.E.: Positive surgical margins at radical prostatectomy: importance of the apical dissection. J. Urol., 143: 1166–1173, 1990.
16.
EpsteinJ.I.: The evaluation of radical prostatectomy specimens: therapeutic and prognostic implications. Pathol. Annu., 26: 159–210, 1991.
17.
HumpreyP.A., FrazierH.A., VollmerR.T., PausonD.F.: Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate specific antigen levels. Cancer, 71: 1821–1827, 1993.
18.
TrueL.D.: Surgical pathology examination of the prostate gland. Practice survey by American Society of Clinical Pathologist. Am. J. Clin. Pathol., 102: 572–579, 1994.
19.
ByarD.P, MostofiF.K.: Veterans administration cooperative urological research group. Carcinoma of the pro-State: prognostic evaluation of certain pathologic features in 208 radical prostatectomies examined by the step-section technique. Cancer, 30: 5–13, 1972.
20.
FowlerJ.E. Jr., MillsS.E.: Operable prostatic carcinoma: correlations among clinical stage, pathological stage, Gleason histological score and early disease-free survival. J. Urol., 133: 49–52, 1985.
21.
AyalaA.G., RoyJ.Y.: The prostatic capsule: does it exist? Am. J. Surg. Pathol., 13 (1): 21–27, 1989.
22.
JewettH.J., EgglestonJ.C., YawnD.H.: Radical prostatectomy in the management of carcinoma of the prostate: Probable causes of some therapeutic failures. J. Urol., 107: 1034–1040, 1972.
23.
WalshP.C., JewettH.J.: Radical surgery for prostatic cancer. Cancer, 45: 1906–1911, 1980.
24.
MiddletonR.G., SmithJ.A. Jr., MelzerR.B., HamiltonP.E.: Patient surival and local recurrence rate following radical prostatectomy for prostatic carcinoma. J. Urol., 135: 422–424, 1986.
25.
PaulsonD.F., StoneA.R., WaltherP.J.: Radical prostatectomy: anatomical predictors of success or failure. J. Urol., 136: 1041–1043, 1986.
26.
VillersA.A., McNealJ.E., RedwineE.A.: Pathogenesis and biological significance of seminal vescicle invasion in prostatic adenocarcinoma. J. Urol., 143: 1183–1187, 1990.
27.
StameyT.A., McNealJ.E., FreihaF.S., RedwineE.A.: Morphometric and clinical studies on 68 consecutive radical prostatectomies. J. Urol., 139: 1235–1241, 1988.
28.
HeringF., RistM., RothJ.: Does microinvasion of the capsule and/or micrometastases in regional lymph nodes influence disease-free survival after radical prostatectomy? Br. J. Urol., 66: 177–181, 1990.
29.
ProutG.R. Jr., HeaneyJ.A., GriffinP.P.: Nodal involvement as a prognostic indicator in patients with prostatic carcinoma. J. Urol., 124: 226–231, 1980.
30.
GrossmanH.B., BatataM., HilarisB., WhitmoreW.F. Jr.: I 125 implantation for carcinoma of prostate. Urology, 20: 591–598, 1982.
31.
KramerS.A., ClineW.A. Jr., FarnhamR.: Prognosis of patients with stage D1 prostatic adenocarcinoma. J. Urol., 125: 817–819, 1981.
32.
ZinckeH., UtzD.C., TaylorW.F.: Bilateral pelvic lymphadenectomy and radical prostatectomy for clinical stage C prostatic cancer. J. Urol., 135: 1199–1205, 1986.
33.
ZinckeH., UtzD.C.: Observations on surgical management of carcinoma of prostate with limited nodal metastases. Urology, 24: 137–145, 1984.
34.
SmithJ.A. Jr., MiddletonR.G.: Implications of volume of nodal metastasis in patients with adenocarcinoma of the prostate. J. Urol., 133: 617–619, 1985.
35.
BrawnP., KuhlD., JohnsonC.III: Stage D1 prostate carcinoma: the histologic appearance of nodal metastases and its relationship to survival. Cancer, 65: 538–543, 1990.
36.
BrawnP.: Histologic features of metastatic prostate cancer. Hum. Pathol., 23: 267–272, 1992.
37.
McNealJ.E.: Cancer volume and site of origin of adenocarcinoma in the prostate: relationship to local and distant spread. Hum. Pathol., 23: 258–266, 1992.
38.
HumpreyP.A., WaltherP.J.: Adenocarcinoma of the prostate. Part. 2: tissue prognosricators. Am. J. Clin. Pathol., 100: 256–269, 1993.
