Abstract
From September 1992 to February 1994, 1441 men aged between 50 and 70 years underwent screening with PSA and ER measurement for early diagnosis of prostatic carcinoma. A neoplasm was diagnosed in 1.73% (25/1441) of cases, which being found at an early stage, made it possible to perform prostatectomy and radical radiotherapy on 37.5% and 16.6% of patients respectively. The incidence of the disease was higher than in a previous screening with just ER dosage (1.73% vs 1.1%). Combined PSA and ER also gave higher sensitivity, specificity, overall accuracy and predictiveness compared to the methods taken individually. This combination seems preferable, in view of the greater efficacy and “practicability” compared to protocols which involve the use of USTR, which is less practicable on a large scale due to the length of time required and high costs. The utility of periodic determination of PSA levels in those over fifty years old is emphasised, both for oncological screening controls and to increase the diagnostic accuracy of other clinical tests.
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