Abstract
From March to December 1991, 10 patients with BPH and urinary retention, not elegible for surgery were treated with Leuprolide at the Department of Urology of B. Ramazzini Hospital in Carpi. The drug was administered subcutaneously or i.m. every 30 days for at least 12 months. The average number of injections was 5. All the patients could void spontaneously after 1-2 injections of the drug. The prostate volume was controlled by digital palpation and rectal ultrasound. A reduction in volume of 25% was observed after 3 months on transrectal ultrasound. PSA was determined and controlled in 5 patients only. All the patients had a decreased PSA value after administration of the drug. No important side effects were observed in the study. We believe that LH-RH injection is a useful therapy in patients with BPH and urinary retention, who are not candidates for surgery.
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