Neoplasie primitive della vescica pT1-G3: Recidive e progressioni. Dieci anni di follow-up * : Primitive bladder neoplasms pT1-G3: Recurrences and progression. Ten years of follow-up

Abstract

72 primitive bladder cancer patients pT1G3, 64 males and 8 females, mean age 62.3, underwent T.U.R. or T.V.R. In this series we evaluated the percentage of recurrences, progression and survival, with a follow-up of 10 years. Among 72 patients, 26 showed unifocal lesions and 46 multifocal lesions. In the case of progression, patients underwent radical surgery (cystectomy). After 10 years the 26 patients with unifocal lesions showed a 90% recurrence rate and 56% progression rate, while the 46 patients with multifocal lesions showed 100% recurrence rate and 71% progression rate. A multivariate analysis was done, considering patient age and sex, number of lesions (unifocal or multifocal) and DNA ploidy (diploid/aneuploid). Only the DNA pattern was a determining factor for selecting progression risk cases. PT1 bladder cancers must be considered as invasive forms. Very careful therapeutic evaluation is therefore necessary.