Abstract
We studied the c-ras oncogene and p53 oncosuppressorgene products (p21, p53) and also some integrine in prostatic cancer and BPH patients to evaluate a possible prognostic value. p21 was detected only in cancer tissue without any significant difference between different stages and grades of prostatic disease. p53 was more expressed in prostatic cancer than BPH, without any statistical difference. No correlation between p53 expression and different stages and grades was demonstrated. Fibronectin receptor (integrin) was significantly higher in cancer than BPH (P < 0,05). p53 expression, only in stage D patients, was related to a significant shorter progression time (P < 0,0001). Fibronectin receptor correlated with a significantly higher progression risk (Odds Ratio = 2,5).
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